Antiparasitic effects of gold nanoparticles with microwave radiation on promastigotes and amastigotes of<i>Leishmania major</i>

Sazgarnia, Ameneh; Taheri, Ahmad Reza; Soudmand, Samaneh; Parizi, Azam Jafari; Rajabi, Omid; Darbandi, Mahdi Sadat

doi:10.3109/02656736.2012.758875

Cited by 49 publications

(25 citation statements)

References 46 publications

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“…In previous years, several kinds of nanoparticles have been proposed as anti-parasite agent [1,16,24]. With respect to increase in resistance to existing anthelmintic, there is an urgent need to investigate novel strategies for control of parasites.…”

Section: Discussionmentioning

confidence: 99%

Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorum

et al. 2017

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In the present study, zinc oxide (ZnO) and iron oxide (FeO) nanoparticles were examined for their possible, in vitro anthelmintic effects against Toxocara vitulorum. The worms were incubated for 24 h with different concentrations (0.004, 0.008 and 0.012% w/v) of the nanoparticles. The parasite mobility, mortality, superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) level were recorded at different time intervals. The results showed that both of the nanoparticles could significantly decrease worm's mobility, increase mortality rate as well as elevate MDA and NO content as compared to control group in a time-and concentrationdependent manner. SOD activity was elevated with the low concentration of the nanoparticles but it was decreased in higher ones. It can be concluded that ZnO and FeO nanoparticles exert their anthelmintic effects via induction of oxidative/nitrosative stress.

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Section: Discussionmentioning

confidence: 99%

Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorum

et al. 2017

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“…The high extinction coefficient of radiation by the GNPs which is due to the coherent oscillations of electrons in gold metal is intensified by inducing RF radiation (18-20). This phenomenon can be used in various applications such as hyperthermia of RCC (21). It should be noted that, for healthy tissues, the toxicity of GNPs can be determined by size, shape, surface charge, and surface coating, however, the overall toxicity dose of GNPs is in an acceptable level (17).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that thermotherapy using microwave radiation in synergism with GNPs may be proposed as a new approach to treat leishmaniasis in future studies (21). Moreover, magnetic nanoparticles (MNPs) have been employed as a potent device in numerous biological and medical investigations (22).…”

Section: Introductionmentioning

confidence: 99%

Effects of radiofrequency radiation in the presence of gold nanoparticles for the treatment of renal cell carcinoma

et al. 2016

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Introduction: The most common type of kidney cancer is renal cell carcinoma (RCC), which accounts for more than 80% of all kidney cancers. Objectives: The aim of this study was to evaluate the effects of radiofrequency (RF) radiation in the presence of gold nanoparticles (GNPs) for the treatment of RCC. Materials and Methods: Human embryonic kidney (HEK) cancer cells were divided into 6 groups. Various tests were performed on HEK cells in the presence of RF and GNPs. In order to investigate the radiation effects on the cells’ survival, MTT [3-(4,5-dimethylthiazol–2-yl)-2,5-iphenyltetrazolium bromide] assay was performed at different days during and post-irradiation period. The repeated measure analysis of variance (ANOVA) method was used for statistical analysis of the cells’ survival using SPSS version 16.0. A significant level of 0.05 was considered to the tests. Results: Using the ANOVA test, a significant decrease in cell’s survival was seen in the RF exposed group 3 compared to the control group (P=0.035). While, differences were not significant between RF exposed group 2 and the control group (P>0.05). A significant decrease in cell’s survival in the RF exposed groups 5 (P=0.025) and 6 (P=0.018) at the presence of GNP compared to the control group was seen. Conclusion: Results of this study showed that, this method can be efficiently used for RCC treatment as an alternative to nephrectomy. More follow up in vivo studies on mammalians are needed to investigate the potential of the presented method for clinical applications.

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“…Cutaneous leishmaniasis (CL) is a parasitic disease caused by various species of Leishmania such as Leishmania major (L. major). This disease is transmittable to humans by the female sandfly of Phlebotomus species [Sazgarnia et al, ]. L. major begins its lifecycle in the gut of the sandfly; these parasites transform from aflagellated amastigotes into flagellated promastigotes for 1–2 weeks.…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles and electroporation: Their combinational effect on Leishmania major

Dolat

Rajabi

Salarabadi

et al. 2015

Bioelectromagnetics

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Leishmaniasis is an emerging and uncontrolled disease. The use of routine drugs has been limited due to proven side effects and drug resistance. Interestingly, novel approaches such as nanotechnology have been applied as a therapeutic modality. Silver nanoparticles have shown antileishmanial effects but because of their nonspecific and toxic effects on normal cells, their use has been limited. On the other hand, it has been demonstrated that electric pulses induce electropores on cell membranes resulting in higher entrance of certain molecules into cells. There is a hypothesis proposing that use of electroporation and silver nanoparticles simultaneously can induce greater accumulation of particles in infected cells, besides higher toxicity. In this study, after applying electric pulses with different concentrations of silver nanoparticles (SNPs), cell survival rate was determined by standard viability assays. On the basis of these data, 2 μg/ml of SNPs and 700 V/cm with 100 μs duration of electroporation were selected as the non-lethal condition. Promastigotes and infected macrophage cells received both treatments and the survival percentage and Infection Index were calculated. In parasites and cells receiving both treatments, higher toxicity was observed in comparison to each treatment given individually, showing a synergic effect on promastigotes. Therefore, application of electric pulses could overcome limitations in using the antileishmanial properties of silver nanoparticles.

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Antiparasitic effects of gold nanoparticles with microwave radiation on promastigotes and amastigotes ofLeishmania major

Abstract: Thermotherapy using MW radiation in the presence of GNPs may be proposed as a new approach to treat leishmaniasis in future studies.

Cited by 49 publications

References 46 publications

Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorum

Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorum

Effects of radiofrequency radiation in the presence of gold nanoparticles for the treatment of renal cell carcinoma

Silver nanoparticles and electroporation: Their combinational effect on Leishmania major

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