Antiparasitic potential of asteraceae plants: A comprehensive review on therapeutic and mechanistic aspects for biocompatible drug discovery

Kamaraj, Chinnaperumal; Ragavendran, Chinnasamy; Kumar, Rajappan Chandra Satish; Almasi‐Hashiani, Amir; Khan, Safir Ullah; Mashwani, Zia‐ur‐Rehman; Luna-Arias, Juan Pedro; Pedroza, Juan Pedro Ramirez

doi:10.1016/j.phyplu.2022.100377

Cited by 11 publications

(11 citation statements)

References 161 publications

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“…Sahoo et al (2020) found an anti-malaria activity of xanthinosin (2) and stigmasterol-3-O-β-D-glucopyranoside (3), suggesting that this plant or its components should be used against malaria in the future. Kamaraj et al (2022) also analyzed the traditional methods of treating parasitic diseases using plants of the Asteraceae family, and reviewed the main chemical classes discovered in those plants and their interaction against parasites. Those authors pointed out flavonoids, terpenoids, and alkaloids which had antiparasitic properties.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and anthelmintic activities of Xanthium strumarium (Asteraceae) extracts

Zazharskyi,

Brygadyrenko,

Boyko

et al. 2024

Regul. Mech. Biosyst.

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Plants of the Asteraceae family are broadly used against microorganisms pathogenic to people and animals, although their potential has not been studied completely so far. In an in vitro experiment, we tested ethanolic, ethyl-ether, and dimethyl-sulfoxide extracts from the fruits, leaves, shoots, and roots of Xanthium strumarium L. for their effects on 13 species of bacteria and larvae of 3 species of nematodes. Over-8-mm-wide growth-inhibition zones of the colonies around disks saturated with ethanolic extracts from the fruits were observed for 11 bacteria: Enterobacter cloacae, Klebsiella pneumonia ssp. rhinoscleromatis, K. pneumonia ssp. ozaenae, K. aerogenes, Salmonella enterica, Escherichia coli, Morganella morganii, Enterococcus faecalis, E. faecium, Staphylococcus aureus, and Bacillus subtilis. Ethanol extract from the leaves inhibited growth of the colonies of 10 bacteria: E. cloacae, K. pneumonia ssp. rhinoscleromatis, K. pneumonia ssp. ozaenae, S. enterica, E. coli, Proteus vulgaris, E. faecalis, E. faecium, S. aureus, and B. subtilis. Ethanol extract from the stem inhibited growth of the colonies of only 6 bacteria: K. aerogenes, E. cloacae, P. vulgaris, E. faecium, S. aureus, and B. subtilis. Ethanol extract from the root inhibited growth of 10 bacteria: E. cloacae, K. pneumonia ssp. rhinoscleromatis, K. pneumonia ssp. ozaenae, K. aerogenes, S. enterica, E. coli, Pseudomonas aeruginosa, E. faecalis, E. faecium, and S. aureus. We analyzed the effects of extracts based on ethyl ether and dimethyl sulfoxide, finding no antiparasitic activity or expressed anthelmintic properties of various extracts from the fruits, leaves, stem, and roots of X. strumarium against larvae of the nematodes Strongyloides papillosus, Haemonchus contortus, and Muellerius capillaris.

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Section: Discussionmentioning

confidence: 99%

Antibacterial and anthelmintic activities of Xanthium strumarium (Asteraceae) extracts

Zazharskyi,

Brygadyrenko,

Boyko

et al. 2024

Regul. Mech. Biosyst.

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“…Interestingly, the results of the GC/MS analysis were consistent with previous research on P. crispa , which also reported high levels of sterols and/or triterpenes in it [ 21 ]. In addition, studies have reported that the Compositae family commonly contains sitosterol and stigmasterol [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Profile, Antibacterial, Antibiofilm, and Antiviral Activities of Pulicaria crispa Most Potent Fraction: An In Vitro and In Silico Study

et al. 2023

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Infectious diseases caused by viruses and bacteria are a major public health concern worldwide, with the emergence of antibiotic resistance, biofilm-forming bacteria, viral epidemics, and the lack of effective antibacterial and antiviral agents exacerbating the problem. In an effort to search for new antimicrobial agents, this study aimed to screen antibacterial and antiviral activity of the total methanol extract and its various fractions of Pulicaria crispa (P. crispa) aerial parts. The P. crispa hexane fraction (HF) was found to have the strongest antibacterial effect against both Gram-positive and Gram-negative bacteria, including biofilm producers. The HF fraction reduced the expression levels of penicillin binding protein (PBP2A) and DNA gyrase B enzymes in Staphylococcus aureus and Pseudomonas aeruginosa, respectively. Additionally, the HF fraction displayed the most potent antiviral activity, especially against influenza A virus, affecting different stages of the virus lifecycle. Gas chromatography/mass spectrometry (GC/MS) analysis of the HF fraction identified 27 compounds, mainly belonging to the sterol class, with β-sitosterol, phytol, stigmasterol, and lupeol as the most abundant compounds. The in silico study revealed that these compounds were active against influenza A nucleoprotein and polymerase, PBP2A, and DNA gyrase B. Overall, this study provides valuable insights into the chemical composition and mechanism of action of the P. crispa HF fraction, which may lead to the development of more effective treatments for bacterial and viral infections.

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“…The family Asteraceae (Compositae) is present on all continents and has significance as horticultural and garden ornaments as well as medicinal plants, vegetables and pesticides. The most reported molecule of this family is artemisinin from Artemisia annua , which has a lethal effect on multi-resistant Plasmodium falciparum [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most important molecules of the Asteraceae family are the sesquiterpene lactones, as dehydrozaluzanin C and brevilin A from Munnozia maronii and Centipeda minimum , respectively, are both highly effective antiparasitic compounds against Plasmodium , Leishmania , and Trypanosoma . For example, wild chimpanzees chewing stems of Vernonia amygdalina (Asteraceae) led to the development of the antiplasmodial sesquiterpenes vernodalin, vernolide, and hydroxyverniladin [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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3′-Demethoxy-6-O-Demethylisoguaiacin and Norisoguaiacin Nematocidal Lignans from Artemisia cina against Haemonchus contortus Infective Larvae

Higuera-Piedrahita

Dolores-Hernández

Cruz-Cruz

et al. 2023

Plants

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Artemisia cina is a plant used in traditional Chinese medicine as a remedy for parasitic diseases. This study describes the isolation and chemical characterization of anthelmintic compounds of A. cina against Haemonchus contortus infective larvae (L3) through lethal testing. Previously, three extracts—n-hexane (HexAc), ethyl acetate (EtOAc) and methanol (MeOAc)—were evaluated at concentrations of 4 to 0.5 mg/mL, resulting in the HexAc extract with the greatest effect of 76.6% mortality of the larvae at 4 mg/mL. Then, this was chemically fractioned by polarity, obtaining seven fractions (C1F1–C1F7), and, when evaluated at concentrations from 2 to 0.25 mg/mL, the 2 mg/mL C1F5 fraction produced an effect against the nematode H. contortus of 100% mortality of the larvae. Thus, this fraction was fractionated again by column chromatography, obtaining twelve subfractions (C2F1–C2F12) which were evaluated from 1 to 0.125 mg/mL, with the C2F5 subfraction causing a nematicidal effect of 100% mortality. NMR analysis of one (1H, 13C and DEPT) and two dimensions (COSY, HSQC and HMBC) and mass spectrometry of this fraction allowed us to identify the mixture of 3′-demethoxy-6-O-demethylisoguaiacin and norisoguaiacin. Therefore, it can be assumed that the mixture of these compounds is responsible for the anthelmintic effect. These results indicate that A. cina containing anthelmintic compounds and might be used as an antiparasitic drug against H. contortus.

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Antiparasitic potential of asteraceae plants: A comprehensive review on therapeutic and mechanistic aspects for biocompatible drug discovery

Cited by 11 publications

References 161 publications

Antibacterial and anthelmintic activities of Xanthium strumarium (Asteraceae) extracts

Antibacterial and anthelmintic activities of Xanthium strumarium (Asteraceae) extracts

Chemical Profile, Antibacterial, Antibiofilm, and Antiviral Activities of Pulicaria crispa Most Potent Fraction: An In Vitro and In Silico Study

3′-Demethoxy-6-O-Demethylisoguaiacin and Norisoguaiacin Nematocidal Lignans from Artemisia cina against Haemonchus contortus Infective Larvae

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