Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome

Khogeer, Haitham; Alfattani, Areej; Kaff, M Al; shehri, T Al; Khojah, Osamah; Owaidah, Tarek

doi:10.1177/0961203314552462

Cited by 18 publications

(10 citation statements)

References 27 publications

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“…Thus, the current criteria may be at odds with clinical needs for diagnosis of APS in the setting of pregnancy loss [16]. Many other antibodies have been associated with APS (antiprothrombin, antiphosphatidylserine, and antiphosphatidylethanolamine) [17][18][19] in addition to ACL and aB2GPI, although meta-analysis only found significant associations of LA and ACL with venous thrombosis [20]. A variety of laboratory findings may detect aPL, but large prospective studies will be required to adequately determine the clinical significance of these different findings [21].…”

Section: Introductionmentioning

confidence: 96%

Lupus anticoagulant testing using two parallel methods detects additional cases and predicts persistent positivity

Simmons

Herskovits

Battinelli

et al. 2018

Clinical Chemistry and Laboratory Medicine (CCLM)

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Section: Introductionmentioning

confidence: 96%

Lupus anticoagulant testing using two parallel methods detects additional cases and predicts persistent positivity

Simmons

Herskovits

Battinelli

et al. 2018

Clinical Chemistry and Laboratory Medicine (CCLM)

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“… 12 Khogeer et al reported a significant association between IgG antiphosphatidylserine antibodies and APS, especially when they were used to diagnosis clinical cases with other negative aPL tests. 13 Based in part on these reports, we concluded that our patient had APS.…”

Section: Discussionmentioning

confidence: 69%

Takayasu Arteritis With Antiphosphatidylserine/Prothrombin Antibody-Positive Antiphospholipid Syndrome

et al. 2015

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A relationship between Takayasu arteritis (TA) and positive antiphospholipid antibody states has been pointed out, but patients with TA complicated with antiphospholipid antibody syndrome (APS) are rare. Here we report the case of a 17-year-old Japanese man diagnosed with TA based on pulselessness of the left brachial artery, discrepancy of blood pressure between the upper extremities, and arterial wall thickening and narrowing of artery in contrast computed tomography. He was also diagnosed with provisional APS based on a pulmonary infarction without narrowing of the pulmonary artery and positive antiphosphatidylserine/prothrombin antibody. The patient also had concurrent Crohn's disease (CD) based on histopathological findings, which may have been associated with TA. We started high-dose corticosteroid therapy and anticoagulation therapy, and his symptoms including fever, dizziness, chest pain, and lower-right uncomfortable abdomen improved.We reviewed 9 cases of TA with APS including our patient by conducting a PubMed search. Based on past reports, we considered the relationship among TA, APS, and CD.Clinicians should bear in mind that many etiologies can exist in 1 patient, and differential diagnoses are essential.

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“…Interestingly, there have been two case reports of pediatric APS patients with positive anti-PS/PT and thrombotic microangiopathy [ 23 , 24 ]. One other series of APS patients evaluating anti-PS/PT included pediatric patients and showed a significant association between test positivity and APS; it could even be used to diagnose clinical cases when other aPL were negative [ 25 ]. Further research in this area seems warranted.…”

Section: Discussionmentioning

confidence: 99%

Pediatric antiphospholipid syndrome: clinical features and therapeutic interventions in a single center retrospective case series

et al. 2022

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Background/purpose Pediatric antiphospholipid syndrome (APS) is a thromboinflammatory disease characterized by the presence of circulating antiphospholipid antibodies and either thrombotic events or pregnancy morbidity. The objective of this study was to review a large institution’s experience to better understand the characteristics of children with APS. Methods We conducted a retrospective review of pediatric APS at a tertiary referral center. The electronic medical record system was queried from 2000 through 2019, and 21 cases were included based on meeting the revised Sapporo Classification criteria by age 18 or younger. Comparisons between primary and secondary APS patients were made with two-tailed t-tests. Results Twenty-one patients were included with a median age at diagnosis of 16 years and median follow-up of 5.8 years. Secondary APS was slightly more common than primary APS (11 vs. 10 cases) and was primarily diagnosed in the context of systemic lupus erythematosus. Two thirds of patients (67%) also had “non-criteria” manifestations of APS including thrombocytopenia, autoimmune hemolytic anemia, and livedo reticularis/racemosa. Almost half of patients (43%) had recurrent thrombosis, typically when patients were subtherapeutic or non-adherent with anticoagulation. Damage Index in Patients with Thrombotic APS (DIAPS) scores indicated a chronic burden of disease in both primary and secondary APS patients. Conclusion This case series of pediatric APS provides important context regarding disease phenotypes displayed by children with APS. High prevalence of non-criteria clinical manifestations highlights the need to consider these characteristics when developing pediatric-specific classification criteria and when considering this relatively rare diagnosis in pediatric practice.

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Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome

Cited by 18 publications

References 27 publications

Lupus anticoagulant testing using two parallel methods detects additional cases and predicts persistent positivity

Lupus anticoagulant testing using two parallel methods detects additional cases and predicts persistent positivity

Takayasu Arteritis With Antiphosphatidylserine/Prothrombin Antibody-Positive Antiphospholipid Syndrome

Pediatric antiphospholipid syndrome: clinical features and therapeutic interventions in a single center retrospective case series

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