Antiphospholipid antibodies and lipoprotein (a) in women with recurrent fetal loss

Szczepański, Maciej; Bauer, Alicja; Gardas, Andrzej; Duchiński, T.

doi:10.1016/s0020-7292(98)00007-1

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Previous reports have shown an association with preeclampsia, 22,23 while others have not been able to show an associa-tion. 24 Other associations suggested are with recurrent fetal loss, 25 fetal growth restriction. 26 To our knowledge, the finding that elevated mean lipoprotein A levels may increase the risk of thrombosis in pregnancy has not previously been described.…”

Section: Discussionmentioning

confidence: 99%

Association Between Inherited Thrombophilias, Antiphospholipid Antibodies, and Lipoprotein A Levels and Venous Thromboembolism in Pregnancy

Ogunyemi¹,

Cuéllar²,

Ku³

et al. 2003

Am J Perinatol

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The objective of this study is to evaluate the association between venous thromboembolism (VTE) in pregnancy with thrombophilic factors. Thirty pregnant women with VTE were compared with 30 pregnant women matched by age and race without VTE and evaluated for risk factors and thrombophilia. Statistical analysis used two-tailed Fisher's exact test. VTE distribution was 30% in first trimester, 9% in 2nd trimester, 26% in 3rd trimester and 35% postpartum. Seventeen (57%) of VTE cases versus 2 (7%) of control cases had specific thrombophilia diagnosis ( p <0.001). The results were: Factor V Leiden mutation (27 vs. 3%) p = 0.026, MTHFR homozygous 677 mutation (10 vs. 44%) p = 0.017, prothrombin gene mutation (11 vs. 0%), protein C deficiency (7 vs. 0%), antiphospholipid antibodies (27 vs. 3%) p = 0.026, mean lipoprotein levels 49 versus 23 mg/dL, p = 0.008, mean homocysteine levels 7.8 versus 7.1 umol/L. An association is suggested between thromboembolic events in pregnancy and thrombophilia, especially Factor V Leiden gene mutation and elevated antiphospholipid antibodies. A new finding is the association of elevated lipoprotein A levels with thromboembolic events in pregnancy.

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Section: Discussionmentioning

confidence: 99%

Association Between Inherited Thrombophilias, Antiphospholipid Antibodies, and Lipoprotein A Levels and Venous Thromboembolism in Pregnancy

Ogunyemi¹,

Cuéllar²,

Ku³

et al. 2003

Am J Perinatol

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“…Eine Herzinsuffizienz zusätzlich zur PAVK setzt die periphere Durchblutung durch die verminderte kardiale Auswurfleistung herab und verschlechtert die Offenheitsraten nach endovaskulärer Intervention, was zu gesteigerten Amputationsraten führt [3,4,12,43,44,46]. Ein Diabetes mellitus stellt unabhängig vom Typ einen Risikofaktor für eine PAVK, insbesondere einer distal ausgeprägten AVK und einer koronaren Mehrgefäßerkrankung dar und führt vielmals zur Notwendigkeit einer koronaren und/oder peripheren Bypassoperation im Vergleich zu Nichtdiabetikern [10,13,21,57]. Eine frühzeitig auftretende PAVK (vor dem 50.…”

Section: Infobox 1 Periphere Arterielle Verschlusskrankheit (Pavk)unclassified

Der Biomarker Lipoprotein(a) – Lp(a) in der Diagnostik der peripheren arteriellen Verschlusskrankheit

et al. 2021

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ZusammenfassungDie vorliegende Übersicht zum Biomarker „Lipoprotein(a) – Lp(a)“ wird im Rahmen der Serie Diagnostika des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert, die sich mit dem immer häufigeren Gebrauch der Bestimmung von spezifischen Markern bei sog. Manager-Vorsorgen und Check-up-Untersuchungen beschäftigt. Lipoprotein(a), Lp(a), eignet sich grundsätzlich nicht für solche Vorsorgen, sondern ist ein Marker zur Risikoabschätzung der peripheren arteriellen Verschlusskrankheit. Hier zeigt dieser eine hohe Sensitivität und Spezifität, wobei der Marker aber auf keinen Fall als Screeningparameter zur Frühdiagnostik eingesetzt werden sollte.

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“…13,14 Pathologically elevated Lp(a) has been associated with PE, 15 FGR, 16 and RPL. 17,18 Since both proteins, ANXA5 and Lp(a), are involved in the formation of the thromboplastin complex and high circulating concentrations of Lp(a) would effectively reduce the anticoagulation potential of ANXA5, we aimed to evaluate the distributions of M2/ANXA5 carriers in patients with RPL having normal and elevated Lp(a) levels.…”

Section: Introductionmentioning

confidence: 99%

Lower Incidence of M2/ANXA5 Carriage in Recurrent Pregnancy Loss Patients With Elevated Lipoprotein(a) Levels

Rogenhofer

Engels

Bogdanova³

et al. 2013

Clin Appl Thromb Hemost

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This study compared the incidence of M2/ANXA5 haplotype carriage, a documented repeated miscarriage risk factor, in patient groups with normal and elevated lipoprotein(a) (Lp(a)) levels. A total of 138 women with ≥2 consecutive, idiopathic recurrent miscarriages, categorized in patients with elevated (≥30 mg/dL, n = 44) and normal Lp(a) level (<30 mg/dL, n = 94) were recruited at the recurrent pregnancy loss (RPL) clinic of Munich Großhadern University Hospital. A total of 500 fertile women served as controls. All patients were genotyped for ANXA5 promoter haplotypes, genetic frequencies were compared, and odds ratios (ORs) and relative risks of M2 carriers were calculated. Women with M2 haplotype had an almost 2 times higher relative risk of RPL (OR 2.6, 95% confidence interval 1.5-4.6, P = .001) than fertile controls. Furthermore, risk rises to 2.47 in patients having normal Lp(a) levels (OR 3.2, 95% confidence interval 1.7-5.9, P = .001), whereas women with high Lp(a) levels exhibit notably lower apparent RPL risk of 1.39 (OR 1.4, 95% confidence interval 0.5-4.1, P = .659).

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Antiphospholipid antibodies and lipoprotein (a) in women with recurrent fetal loss

Abstract: Of all four determined variables, only abnormally high values of lipoprotein (a) may have some prognostic significance in women predisposed to the recurrent fetal loss.

Cited by 7 publications

References 11 publications

Association Between Inherited Thrombophilias, Antiphospholipid Antibodies, and Lipoprotein A Levels and Venous Thromboembolism in Pregnancy

Association Between Inherited Thrombophilias, Antiphospholipid Antibodies, and Lipoprotein A Levels and Venous Thromboembolism in Pregnancy

Der Biomarker Lipoprotein(a) – Lp(a) in der Diagnostik der peripheren arteriellen Verschlusskrankheit

Lower Incidence of M2/ANXA5 Carriage in Recurrent Pregnancy Loss Patients With Elevated Lipoprotein(a) Levels

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