Antiphospholipid Antibodies and Necrotizing Purpura

Naldi, Luigi; Marchesi, L.; Finazzi, Guido; Locati, Francesco; Cainelli, T.

doi:10.1159/000248046

Cited by 15 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Post‐phlebitic ulcers were observed in patients with recurrent phlebitis of the leg, after many years of followup. In contrast, circumscribed skin necrosis is frequently an early feature of APS, often preceded by necrotizing purpura (22, 23). In a series of 21 consecutive patients with atrophie blanche–like ulcers or livedoid vasculitis, aPL were detected in 4 (19%), of whom 1 had SLE‐related APS and 3 had primary APS (24).…”

Section: Discussionmentioning

confidence: 99%

Dermatologic manifestations of the antiphospholipid syndrome: Two hundred consecutive cases

Françès

Niang

Laffitte

et al. 2005

Arthritis & Rheumatism

209

113

View full text Add to dashboard Cite

Objective. To describe dermatologic manifestations of the antiphospholipid syndrome (APS) and to investigate possible correlations between livedo reticularis and other APS manifestations.Methods. We conducted a single-center study of 200 consecutive patients with primary or systemic lupus erythematosus-related APS. To qualify for the study, patients had to fulfill clinical and laboratory criteria from the most recent international consensus statement on classification of definite APS. Dermatologic manifestations were systematically evaluated by a dermatologist. Only dermatologic lesions that may be related to APS were included in the analyses. Correlations between livedo reticularis and other APS manifestations were determined using Fisher's 2-tailed, chi-square, and nonparametric Mann-Whitney tests.Results. Dermatologic manifestations were noted in 49% of the patients and were the presenting manifestations in 30.5%. Livedo reticularis was the most frequent manifestation, observed in 25.5% of the patients. Livedo reticularis was shown to be significantly associated with cerebral or ocular ischemic arterial events (odds ratio [OR] 10.8, 95% confidence interval [95% CI] 5.2-22.5), seizures (OR 6.5, 95% CI 2.6-16), all arterial events (OR 6, 95% CI 2.9-12.6), heart valve abnormalities detected on echocardiography (OR 7.3, 95% CI 3.6-14.7), and arterial systemic hypertension (>160/90 mm Hg) (OR 2.9, 95% CI 1.5-5.7). Conversely, it was observed with decreased frequency in patients with only venous thrombosis (OR 0.2, 95% CI 0.1-0.5).Conclusion. The dermatologic manifestations of APS are frequently the presenting feature of the syndrome, and livedo reticularis is significantly associated with the arterial subset of APS.

show abstract

Section: Discussionmentioning

confidence: 99%

Dermatologic manifestations of the antiphospholipid syndrome: Two hundred consecutive cases

Françès

Niang

Laffitte

et al. 2005

Arthritis & Rheumatism

209

113

View full text Add to dashboard Cite

show abstract

“…Necrotizing purpura may precede livedoid vasculitis-like ulcers by years. 50,51 This term has been applied to a form of cutaneous necrosis.…”

Section: Dermatologic Findingsmentioning

confidence: 99%

Dermatologic aspects of antiphospholipid syndrome

Gantcheva

1998

Int J Dermatology

View full text Add to dashboard Cite

“…The most frequent cutaneous manifestation was spontaneous thrombophlebitis syndrome (34%), followed by skin ulcer (30%), gangrene (19%), haemorrhage (14%) and cutaneous necrosis (3%). Some authors have reported isolated cases of rare cutaneous changes associated with APS such as necrotizing vasculitis, 19 livedoid vasculitis 20 or cutaneous nodules. 5,6 A small papule or a subcutaneous nodule emerged as a cutaneous manifestation of APS in four patients in our series.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous papules and nodules in the diagnosis of the antiphospholipid syndrome

et al. 1999

View full text Add to dashboard Cite

Of 11 patients with primary or secondary antiphospholipid syndrome (APS), four exhibited papules or nodules on the finger, sole or leg as the initial cutaneous manifestation. Histological examination demonstrated thrombosed vessels or vessels containing organized thrombi in the dermis or in the subcutaneous fat tissue. Cutaneous papules and nodules should be recognized as skin manifestations of APS. Screening tests for antiphospholipid antibodies and lupus anticoagulant are required in patients with cutaneous papules or nodules of unknown aetiology. In cases of positive antiphospholipid antibodies and/or lupus anticoagulant, histological examination is critical in the establishment of the diagnosis of APS.

show abstract

Antiphospholipid Antibodies and Necrotizing Purpura

Cited by 15 publications

References 18 publications

Dermatologic manifestations of the antiphospholipid syndrome: Two hundred consecutive cases

Dermatologic manifestations of the antiphospholipid syndrome: Two hundred consecutive cases

Dermatologic aspects of antiphospholipid syndrome

Cutaneous papules and nodules in the diagnosis of the antiphospholipid syndrome

Contact Info

Product

Resources

About