Antiphospholipid antibodies in patients with purported ‘chronic Lyme disease’

Greco, Thomas; Conti-Kelly, AM

doi:10.1177/0961203311414098

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…Although causality with prior infection cannot be clearly established, the results are consistent with a number of previous studies in patients with complicated forms of Lyme disease and post-Borreliosis syndrome, in which antibodies to a variety of autoantigens were found, such as annexin A2 [75], apolipoprotein B-100 [76], endothelial cell growth factor [77], matrix metalloproteinase-10 [78], phospholipids [79], cyclophilin [80], neural tissue [81,82], γ-enolase [83], ANA, and myositis-associated antibodies [47]. The wide range of specificities of the autoantibodies found suggests the non-specific polyclonal activation of cells of the immune system rather than the cross-reactivity of microbial antigens with autoantigens.…”

Section: Discussionsupporting

confidence: 90%

Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

et al. 2021

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The hypothesized importance of coinfections in the pathogenesis of post-treatment Lyme disease syndrome (PTLDS) leads to the use of combined, ongoing antimicrobial treatment in many cases despite the absence of symptoms typical of the presence of infection with specific pathogens. Serum samples from 103 patients with suspected post-treatment Lyme disease syndrome were tested for the presence of antibodies to the major tick-borne pathogens Anaplasma phagocytophilum, Bartonella henselae/Bartonella quinatana, and Babesia microti. Although the presence of anti-Anaplasma antibodies was detected in 12.6% of the samples and anti-Bartonella antibodies in 9.7% of the samples, the presence of antibodies against both pathogens in the same samples or anti-Babesia antibodies in the selected group of patients could not be confirmed. However, we were able to detect autoantibodies, mostly antinuclear, in 11.6% of the patients studied. Our results are in good agreement with previously published studies showing the presence of a wide spectrum of autoantibodies in some patients with complicated forms of Lyme disease and post-treatment Lyme disease syndrome, but they do not reveal a significant influence of co-infections on the development of PTLDS in the studied group of patients.

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Section: Discussionsupporting

confidence: 90%

Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

et al. 2021

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“…As a result, positive aCL results due to infectious disease remain likely today. Furthermore, it is sometimes not possible to determine how aPL were measured in published reports [52].…”

Section: Transient Versus Persistent Antibodiesmentioning

confidence: 99%

Anti-phospholipid Antibodies and Smoking: An Overview

Binder

Litwin

2016

Clinic Rev Allerg Immunol

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Antiphospholipid syndrome is characterized by the presence of antiphospholipid antibodies, specifically lupus anticoagulant, anticardiolipin antibodies, and anti-β2 glycoprotein-I antibodies. Antiphospholipid syndrome can occur on its own or in association with other autoimmune diseases, most commonly systemic lupus erythematosus (SLE). A connection between cigarette smoking and anti-phospholipid antibodies (aPL) was first reported in the late1980s. Systemic lupus erythematosus patients with aPL are more likely to be smokers than those without aPL. These patients have a particularly high frequency of vascular events. Recently, a potential link between periodontitis, tobacco, and aPL has been proposed. Research has also suggested that periodontitis and Porphyromonas gingivalis infection are associated with citrullination through the action of peptidylarginine deiminase. A strong correlation between smoking and the presence of citrillunated autoantibodies, which are characteristic of rheumatoid arthritis, has also been observed. While many studies have investigated possible links between infection and aPL in patients with autoimmune diseases, the association of smoking with aPL has not been systematically examined. The fact that both aPL and tobacco are risk factors for thrombosis has complicated efforts to evaluate these factors separately. Also, there has been great variability in measurement techniques, and laboratories lack routine methods for differentiating transient and persistent aPL; both of these factors can make interpretation of autoantibody results quite challenging. This review summarizes the clinical evidence supporting a posited link between aPL and smoking, both in patients with a systemic autoimmune disease and in patients with other medical conditions.

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“…Reminiscent of the name chronic fatigue syndrome (Jason, Holbert, Torres-Harding, & Taylor, 2004), even the term PTLDS remains disputed, with some patients, advocacy groups, and physicians preferring chronic Lyme disease (CLD) instead (Cameron, Johnson, & Maloney, 2014; Specter, 2013). However, CLD is frequently criticized in the medical literature and is at times presented in quotation marks in peer-reviewed publications, lending additional tenuousness to the term (Baker, 2008; Greco, Conti-Kelly, & Greco, 2011; Hassett, Radvanski, Buyske, Savage, & Sigal, 2009). The label CLD is primarily criticized for its lack of specificity, and the implication of antibiotic-resistant infection as a potential underlying cause of the symptoms (Auwaerter & Melia, 2012; Feder et al, 2007; Lantos, 2015; Sigal & Hassett, 2005), a hypothesis not supported or adopted by IDSA guidelines (Wormser et al, 2006).…”

mentioning

confidence: 99%

Living in Limbo

et al. 2016

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Persistent, subjective symptoms of unknown etiology following treatment for Lyme disease have been termed post- treatment Lyme disease syndrome or chronic Lyme disease (PTLDS/CLD). The objective of this study was to give primacy to the patient experience of this medically contested condition by eliciting patient illness narratives and identifying emergent issues through semistructured interviews conducted among 29 participants. We used thematic narrative analysis to identify three predominant themes: (a) Physical and social limitations lead to a "new normal" characterized by fundamental shifts of ways of being in the world, (b) disease-specific factors contribute to symptom and illness invisibility that affects social support in nuanced ways, and (c) pervasive medical uncertainty regarding PTLDS/CLD promotes an increased sense of personal responsibility for care. Similar to other contested or medically unexplained syndromes, our findings suggest that the social sequelae of PTLDS/CLD can be equally protracted as the physical effects of this illness.

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Antiphospholipid antibodies in patients with purported ‘chronic Lyme disease’

Abstract: aPL occurs frequently in patients with 'CLD'. IgM anti-β2GP1, IgM aCL and IgM WB were frequently found. Documented PLS or LLD was uncommon. The role of aPL in patients with 'CLD' needs further investigation.

Cited by 11 publications

References 27 publications

Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

Anti-phospholipid Antibodies and Smoking: An Overview

Living in Limbo

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