Antiphospholipid antibodies in patients with Graves’ orbitopathy: preliminary data

Bećarevic, Mirjana; Matutinović, Marija Sarić; Žarković, Miloš; Beleslin, Biljana; Ćirić, Jasmina; Ignjatović, Svetlana

doi:10.1007/s12020-021-02769-z

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…17 The first case of orbital myositis as a manifestation of primary antiphospholipid syndrome was only documented in 2017 18 ; the first report of antiphospholipid antibodies in patients with Graves’ orbitopathy was published in 2021. 17 Further exploration of the general role of antiphospholipid antibodies in causing orbital inflammation is warranted.…”

Section: Discussionmentioning

confidence: 99%

An Orbital Manifestation of VEXAS Syndrome

Lokhande

Jarmale

Vaishnav

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is an adult-onset autoinflammatory disorder characterized by systemic inflammation (vasculitis, arthritis, chondritis, dermatosis) and hematologic abnormalities (thrombosis, cytopenia, vacuolization of marrow precursors). The patient demonstrated some of the adult-onset inflammatory and hematologic features, in addition to recurrent eye pain, chemosis and orbital inflammation. This case describes an instance of VEXAS syndrome in a patient with uncommon orbital symptoms such as scleritis and myositis.

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Section: Discussionmentioning

confidence: 99%

An Orbital Manifestation of VEXAS Syndrome

Lokhande

Jarmale

Vaishnav

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…There are several studies that investigated the prevalence of aPL Abs in healthy subjects of various nationalities (10)(11)(12) and numerous studies that compared levels of aPL Abs in patients with different autoimmune disease vs. healthy subjects (13)(14)(15). We have previously reported (13) that in 47 Serbian young (mean ± SD, 39.68 ± 13.93, 33 female) lean, healthy adults, levels of aPL Abs were significantly lower in comparison to patients with primary APS and that levels of analyzed serum lipids (cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides) were below cut-off values in these young subjects.…”

Section: Introductionmentioning

confidence: 99%

Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data

Bećarevic¹,

Jovičić²,

Ignjatović³

et al. 2022

J Med Biochemistry

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Backgroud: The investigation of the prevalence of the IgG and the IgM isotypes of anticardiolipin (aCL) and anti-β2glycoprotein I (aβ2gpI) Abs in healthy Serbian middle-aged subjects was the main goal of our study. In addition, we analyzed the potential associations of above-mentioned Abs with serum proteins and lipids/lipoproteins. Methods: Forty healthy subjects were included in our study. Obesity (BMI ≥ 30 kg/m2) was present in 8/40 (20%) subjects. Titers of analyzed Abs were measured by ELISA. Results: The prevalence of IgG and IgM aβ2gpI Abs was 5% and 12.5%, respectively, while the prevalence of IgM aCL was 10%. The IgG aβ2gpI Abs were significantly different between subjects with normal triglycerides levels and those with hypertriglyceridemia (Mann-Whitney, P = 0.014). The significant difference in hsCRP concentrations was observed between subjects with the increased levels of the IgM isotype of aCL Abs and those with normal IgM aCL values (Mann-Whitney, P = 0.028). Conclusion: Dyslipidemia and BMI ≥30 were associated with aPL Abs and therefore, the correction of BMI and lipid status might be beneficial in reduction or elimination of predisposing factors that might trigger thrombotic events in otherwise healthy middle-aged subjects. Larger national study is necessary to confirm our findings.

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Periorbital Necrotizing Sweet’s Syndrome: A Case Report

Watson,

Kuo,

Kishi

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Sweet’s syndrome (acute febrile neutrophilic dermatosis) is an uncommon inflammatory condition most often associated with painful skin lesions of the head, neck, and upper extremities. To the authors’ knowledge, this case report is the only published record of the necrotizing clinical variant of Sweet’s syndrome in the periorbital space. This case follows a 91-year-old female who presented with generalized cutaneous eruptions of tender erythematous plaques, including a necrotic plaque of the left upper eyelid, and pancytopenia. A biopsy of an inner thigh lesion was consistent with Sweet’s syndrome. Initially diagnosed with preseptal cellulitis, the patient experienced marked clinical improvement with corticosteroids. This, coupled with the histopathologic findings of her thigh biopsy and the absence of eyelid margins, led to the diagnosis of periorbital necrotizing Sweet’s syndrome. Although cases of Sweet’s syndrome in the periorbital region are rare, these diagnoses should not be overlooked and may be critical to patient care.

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Antiphospholipid antibodies in patients with Graves’ orbitopathy: preliminary data

Cited by 3 publications

References 18 publications

An Orbital Manifestation of VEXAS Syndrome

An Orbital Manifestation of VEXAS Syndrome

Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data

Periorbital Necrotizing Sweet’s Syndrome: A Case Report

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