Antiphospholipid antibodies in patients with autoimmune blistering disease

Echigo, Takeshi; Hasegawa, Minoru; Inaoki, Makoto; Yamazaki, Masahide; Sato, Shinichi; Takehara, Kazuhiko

doi:10.1016/j.jaad.2006.07.004

Cited by 21 publications

(23 citation statements)

References 19 publications

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“…We demonstrated the presence of two non-classic antiphospholipid antibodies, aPS-β2GPI and aPT-PT, among ABD patients. Nevertheless, in contrast to Echigo et al [6], classic aPL such as aCL and B2GPI were not found to be more prevalent in our cohort in comparison to control sera. This may be attributed in part to the immunosuppressive therapy of our patients.…”

Section: Discussioncontrasting

confidence: 99%

“…Echigo et al [6] studied the sera of 71 patients with pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid for anticardiolipin antibodies (aCL), anticardiolipin-b2 glycoprotein I complex antibody and antiphosphatidylserine -prothrombin complex using an enzyme-linked immunosorbent assay. They found that the prevalence of IgG and IgM aCL, aCL-β2GPI, and IgG aPS-PT was positive for 22.4%, 9.1%, 9.9%, and 25.4% of the ABD patients, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Novel antiphospholipid antibodies in autoimmune bullous diseases

Sagi¹,

Baum

Barzilai

et al. 2015

HAB

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Novel antiphospholipid antibodies in autoimmune bullous diseases

Sagi¹,

Baum

Barzilai

et al. 2015

HAB

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“…The type of organs involved varied and included the brain and lung. 19 A recent population-based study found that patients with BP are 3 times as likely to develop pulmonary embolism. 20 To the best of our knowledge, this is the first populationbased study to investigate the risk of stroke in a national cohort of patients with BP.…”

Section: Discussionmentioning

confidence: 99%

“…Among 10 patients who tested positive for aPLs, 7 patients had thromboembolisms, although most of them were clinically asymptomatic. 19 aPLs can produce a prothrombic state through inhibition of natural anticoagulant pathways, inhibition of fibrinolytic mechanisms, and induction of endothelial cell procoagulant activity. These processes predispose the patient to thrombotic events, particularly ischemic stroke.…”

Section: Yang Et Al Increased Risk Of Stroke In Patients With Bpmentioning

confidence: 99%

Increased Risk of Stroke in Patients With Bullous Pemphigoid

Yang

Chen

Xirasagar

et al. 2011

Stroke

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Background and Purpose-Although previous research reveals that cardiovascular events and thromboembolic diseases are important causes of death in patients with bullous pemphigoid (BP), the risk of stroke after the diagnosis of BP relative to the general population remains unknown. Using a randomly selected nationwide population-based sample, this study investigates the risk of stroke in patients with BP compared with unaffected individuals of a similar age. Methods-This study analyzes data from Taiwan's National Health Insurance Research Database. This sample included 390 patients with BP and 1950 matched subjects as a comparison group. Stratified Cox proportional hazard regressions were used to calculate the 3-year stroke risk for these 2 groups after adjusting for patient's age, sex, and comorbid medical disorders at baseline. Results-Of the 2340 patients in the sample, 312 patients (13.3%) had strokes during the 3-year follow-up period, 89(22.8% of the patients with BP) in the study group and 223 (11.4% of patients without BP) in the comparison group (PϽ0.001). The hazard ratio for stroke for patients with BP was 2.37 (95% CI, 1.78 to 3.15; PϽ0.001) times as high that for patients without BP within the 3-year follow-up period after adjusting for hypertension, diabetes, hyperlipidemia, heart failure, atrial fibrillation, and coronary heart disease. Conclusions-Patients

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“…For instance, one recent study reported that thromboembolism occurred in patients with autoimmune blistering disease [19]. This process may correlate BP to thrombotic events.…”

Section: Discussionmentioning

confidence: 99%

Predicting the onset of bullous pemphigoid with co-morbidities: A survey based on a nationwide medical database

Kuo

Yang

et al. 2013

2013 IEEE International Conference on Bioinformatics and Biomedicine

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Bullous pemphigoid (BP) is an acute or chronic autoimmune skin disease. It has been reported that poor conditions of general health and increased mortality rates were observed in BP patients, while pathophysiologic reasons of these phenomena merit further investigation yet. In this paper we tried to investigate the co-morbid associations between bullous pemphigoid and various diseases, using a nationwide population-based medical database, NHIRD. 5,933 adult BP patients of ages >= 18 years were extracted from the NHIRD, accompanied with 17,712 age-and sex-matched control subjects. Thirty-one disorders were selected from the Charlson or Elixhauser index for which we tried to evaluate their respective associations with BP. The results obtained revealed that there existed co-morbid relationships between BP and various illnesses, especially for hemiplegia/paraplegia (odds ratio [OR] 8.71), dementia (OR 8.04), fluid electrolyte disorders (OR 6.6), cerebrovascular disease (OR 5.97), moderate/severe liver disease (OR 5.22), weight loss (OR 4.9), and psychoses (OR 4.64). Furthermore, using the study cohort as input data and the retrospective diagnosis records of the abovementioned co-morbidities occurring within 24 months before onset of BP as features, we employed the algorithm of support vector machine (SVM) to generate the prediction model for onset of BP afterward. Subjects labeled as positive by the prediction model were about 9 times more likely than those as negative to actually develop BP. Accordingly, the prediction model created by SVM was valuable for physicians to screen patients with higher risk of BP.

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Antiphospholipid antibodies in patients with autoimmune blistering disease

Cited by 21 publications

References 19 publications

Novel antiphospholipid antibodies in autoimmune bullous diseases

Novel antiphospholipid antibodies in autoimmune bullous diseases

Increased Risk of Stroke in Patients With Bullous Pemphigoid

Predicting the onset of bullous pemphigoid with co-morbidities: A survey based on a nationwide medical database

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