Antiphospholipid Antibody and Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis

Zhu, Wei; Wu, Yan; Xu, Ming; Wang, Jinyu; Yu, Mengsun; Gu, Zheng; Lu, Jiong

doi:10.1371/journal.pone.0122814

Cited by 24 publications

(15 citation statements)

References 30 publications

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“…11,12,23 Venous tortuosity was the most common posterior involvement. 22,26,27,32 APS has also been associated with central retinal vein occlusion, 7,23,27,32–46 branch retinal vein occlusion,, 24,25,34,37,41,45,47–51 central retinal artery occlusion and branch retinal artery occlusion, 37,43,52–58 or the coexistence of both arterial and venous bed thromboses in the same patient. 32,36,59–64 Venous stasis retinopathy, 65,66 vitreous 67,68 and intraretinal hemorrhages, 67 retinal vasculitis, 69,70 cotton wool spots, 67,71 neovascularization, 72 diffuse retinal periphlebitis, …”

Section: Part II – Systematic Review Of Ophthalmological Manifestatiomentioning

confidence: 98%

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Franco

Medina

Balbi

et al. 2020

Lupus

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Objective There is a broad spectrum of eye involvement in antiphospholipid syndrome (APS). The majority of descriptions are presented as case reports that include mostly APS patients secondary to systemic lupus erythematosus (SLE), with no compelling evidence in primary APS (PAPS). This study aimed to describe ocular manifestations in our well-defined PAPS cohort (APS-Rio) and then perform a systematic literature review (SLR) of ocular manifestations in patients with APS or positivity to aPL without SLE. Methods We retrospectively analyzed PAPS patients followed at our outpatient clinics. All patients fulfilled Sydney APS classification criteria (2006). We evaluated them for ocular symptoms and previous ocular diagnoses. Antiphospholipid antibodies and clinical APS manifestations were compared between patients with and without ocular manifestations. For the SLR, electronic databases were searched up to November 2019. Results We studied 105 PAPS patients; 90.5% were female and 56.2% were Caucasian. We found ocular manifestations in 37.1% of our cohort. Thrombosis was the main criteria manifestation (95.2%) and lupus anticoagulant was the most prevalent antibody. Ophthalmologic diagnoses were present in 7 patients, with 5 having retinal vessels thromboses. Amaurosis fugax was the leading complaint, present in 30 patients. In the univariate analysis, amaurosis fugax was related to livedo (p = 0.005), Raynaud’s phenomenon (p = 0.048) and the presence of anticardiolipin antibody (≥40 GPL/MPL) (p = 0.041). Hemianopia was associated with arterial hypertension (p = 0.049). In the multivariate analysis, the only association found was between livedo and amaurosis fugax (OR 4.09, 95%CI 1.5–11.11, p = 0.006). Our SLR incorporated 96 articles of ocular manifestations in patients with PAPS or positivity to aPL without SLE. Ocular findings varied from 5 to 88%, including anterior and posterior segments, orbital and neuro-ophthalmologic changes. Conclusion There is little evidence on ocular manifestations in PAPS. We described an association between livedo and amaurosis fugax. Prospective studies are needed to promote the best treatment and avoid blindness in PAPS patients.

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Section: Part II – Systematic Review Of Ophthalmological Manifestatiomentioning

confidence: 98%

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Franco

Medina

Balbi

et al. 2020

Lupus

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“…[ 13 ] Meta-analysis is a useful statistical tool to gain a more powerful conclusion through pooling consubstantiate but independent studies together. [ 14 ] The purpose of this current meta-analysis was to investigate the relationship between obesity and DR risk of prospective cohorts. Besides, detailed analyses in this study would also provide certain suggestions for improvement of following study designs.…”

Section: Introductionmentioning

confidence: 99%

Association of obesity and risk of diabetic retinopathy in diabetes patients

Zhu

et al. 2018

Medicine

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Background:Diabetic retinopathy (DR) was considered to be a common complication of diabetes. The purpose of the current study was to investigate the potential association between obesity and DR risk by conducting a meta-analysis of prospective studies.Methods:A consummate literature search of PubMed, EMBASE, and web of science was conducted until July 2016. A total of 13 prospective cohort studies were included in this meta-analysis.Results:On meta-analysis of all the studies assessing DR risk, obesity was associated with a significant increase in DR incidence (relative risk [RR], 1.20; 95% confidence interval [CI], 1.01–1.43; I2 = 59.6%). When only proliferative DR (PDR) was considered, no significant association between obesity and risk of PDR was detected. Significant harmful effect was detected in type 2 diabetes mellitus (T2DM) group (RR, 1.40; 95% CI, 1.05–1.87; I2 = 67.6%) but not mixed group (RR, 1.04; 95% CI, 0.97–1.18; I2 = 0.00%). No significant publication bias was detected in the selected 13 studies.Conclusion:Obesity was a risk factor for non-proliferative DR. However additional well-designed and well-conducted epidemiologic studies were required to deepen our understanding of the relation between obesity and DR.

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“…So far, antiphospholipid autoantibodies and their subgroup, anti-cardiolipin autoantibodies, have been associated with RVO, which was summarized nicely in a recently performed meta-analysis [ 31 ]. The analysis performed within this study revealed additional AABs in the serum of the RVO population.…”

Section: Discussionmentioning

confidence: 99%

Section: Autoantibodies Associated With Rvomentioning

confidence: 96%

Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients

Bell

Beutgen

Nickels

et al. 2020

Journal of Ophthalmology

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Purpose. Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular glaucoma (NVG), one of the major complications, is occurring within a 5-year timeframe. Methods. We performed a nested case-control study (1 : 4) within the Gutenberg Health Study (GHS), a population-based, prospective cohort study in the Rhine-Main Region of Germany including 15,010 participants. RVO subjects (n = 59) were identified by grading of fundus photographs. Optic nerves of RVO subjects and age- and sex-matched controls (n = 229) at baseline and their follow-up examination after 5 years were analyzed for glaucomatous alterations. Of all RVO subjects and controls, serum autoantibody profiles were measured using in-house manufactured antigen-antibody microarrays. Results. Of the 59 RVO patients, 3 patients (5%) showed glaucomatous optic disc alterations at baseline, whereas no new glaucoma case was detected at 5-year follow-up. Four of the autoantibodies measured (against dermcidin, neurotrophin-3, superoxide dismutase 1, and signal recognition particle 14 kDa protein) were significantly increased in the serum of RVO patients p<0.001. Multivariable conditional logistic regression analysis showed that 3 of these 4 antibodies were independent of cardiovascular risk factors. Conclusions. We found several autoantibodies associated with RVO, targeting proteins and structures possibly involved in RVO pathogenesis.

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Antiphospholipid Antibody and Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis

Cited by 24 publications

References 30 publications

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Association of obesity and risk of diabetic retinopathy in diabetes patients

Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients

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