Antiphospholipid Antibody Syndrome and Autoimmune Diseases

Ostrowski, Rochella A.

doi:10.1016/j.hoc.2007.10.003

Cited by 25 publications

(10 citation statements)

References 52 publications

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“…Likewise, the ESR, disease activity score, and SSc subset were not found to predict coronary calcification. Antiphospholipid antibodies were present in 13.2% of the SSc patients in this study and were not particularly associated with coronary atherosclerosis, consistent with the results of a previous study (38). Other previously identified predisposing factors to atherosclerosis, including lipoprotein(a) and anti-oxidized LDL antibodies (34,39), are worth examining in future studies.…”

Section: Discussionsupporting

confidence: 91%

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Mok¹,

Lau²,

Chiu³

et al. 2011

Arthritis & Rheumatism

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Objective. Endothelial dysfunction and inflammation are pathogenic mechanisms common to systemic sclerosis (SSc) and atherosclerosis. This study was undertaken to examine the relationship between coronary atherosclerosis, as assessed by the coronary artery calcium score (CACS), and conventional cardiovascular and disease-specific risk factors in SSc patients.Methods. The CACS was measured by computed tomography, and cardiovascular risk factors were examined in SSc patients and compared with controls matched for age, sex, and glycemic status. Disease activity score, antiphospholipid antibodies, highsensitivity C-reactive protein level, and erythrocyte sedimentation rate were measured in SSc patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined.Results. We recruited 53 SSc patients (50 women and 3 men) and 106 controls. The patients had a mean ؎ SD age of 53.1 ؎ 12.9 years and a median disease duration of 9 years. Compared to controls, SSc patients had significantly lower low-density lipoprotein (LDL) cholesterol levels (P ‫؍‬ 0.001), high-density lipoprotein cholesterol levels (P ‫؍‬ 0.01), diastolic blood pressure, waist circumference, and body mass index and were more likely to be receiving vasodilators (all P < 0.001). There was a significantly higher proportion of SSc patients among subjects with more severe coronary calcification (CACS >101) compared to those with lesser severity (CACS <100) (56.5% versus 29.4%; P ‫؍‬ 0.01). Multiple logistic regression analysis revealed SSc to be an independent determinant for a CACS >101 (OR 10.89 [95% CI 2.21-53.75], P ‫؍‬ 0.003) together with age and LDL cholesterol level after adjustment for other cardiovascular risk factors. Among diseasespecific factors, only disease duration (OR 1.14 [95% CI 1.02-1.27], P ‫؍‬ 0.02) was independently associated with more severe coronary calcification (CACS >101).Conclusion. Our findings indicate that SSc is an independent risk factor for coronary calcification, in addition to the conventional risk factors for coronary atherosclerosis, such as age and hypertension.

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Section: Discussionsupporting

confidence: 91%

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Mok¹,

Lau²,

Chiu³

et al. 2011

Arthritis & Rheumatism

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“…Immunologic conditions less frequently associated with aPL are lupus-like syndrome, Sjögren’s syndrome, rheumatoid arthritis, scleroderma, and systemic vasculitis (Ostrowski and Robinson, 2008). …”

Section: Introductionmentioning

confidence: 99%

Antiphospholipid-Related Chorea

Peluso¹,

Antenora²,

Rosa³

et al. 2012

Front. Neur.

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Chorea is a movement disorder which may be associated with immunologic diseases, in particular in the presence of antiphospholipid antibodies (aPL). Choreic movements have been linked to the isolated presence of plasmatic aPL, or to primary, or secondary antiphospholipid syndrome. The highest incidence of aPL-related chorea is detected in children and females. The presentation of chorea is usually subacute and the course monophasic. Choreic movements can be focal, unilateral, or generalized. High plasmatic titers of aPL in a choreic patient can suggest the diagnosis of aPL-related chorea; neuroimaging investigation does not provide much additional diagnostic information. The most relevant target of aPL is β2-glycoprotein I, probably responsible for the thrombotic manifestations of antiphospholipid syndrome. Etiology of the movement disorder is not well understood but a neurotoxic effect of aPL has been hypothesized, leading to impaired basal ganglia cell function and development of neuroinflammation. Patients affected by aPL-related chorea have an increased risk of thrombosis and should receive antiplatelet or anticoagulant treatment.

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“…2) MHC protein complexes were identified and are presumably involved in the presentation of autoantigens [16]. 3) The finding that protein-lipid complexes and lipoprotein particles are associated with Sjögren's syndrome may be consistent with changes in serum lipid levels in Sjögren's syndrome patients [35] although the prevalence of anti-phospholipid antibodies is low in Sjögren's syndrome [36]. 4) Nerve terminals and axons were also prominent cellular components, consistent with the known neurological component of Sjögren's syndrome [37].…”

Section: Utility and Discussionmentioning

confidence: 99%

Text-mining applied to autoimmune disease research: the Sjögren’s syndrome knowledge base

Gorr

Wennblom

Horvath

et al. 2012

BMC Musculoskelet Disord

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BackgroundSjögren’s syndrome is a tissue-specific autoimmune disease that affects exocrine tissues, especially salivary glands and lacrimal glands. Despite a large body of evidence gathered over the past 60 years, significant gaps still exist in our understanding of Sjögren’s syndrome. The goal of this study was to develop a database that collects and organizes gene and protein expression data from the existing literature for comparative analysis with future gene expression and proteomic studies of Sjögren’s syndrome.DescriptionTo catalog the existing knowledge in the field, we used text mining to generate the Sjögren’s Syndrome Knowledge Base (SSKB) of published gene/protein data, which were extracted from PubMed using text mining of over 7,700 abstracts and listing approximately 500 potential genes/proteins. The raw data were manually evaluated to remove duplicates and false-positives and assign gene names. The data base was manually curated to 477 entries, including 377 potential functional genes, which were used for enrichment and pathway analysis using gene ontology and KEGG pathway analysis.ConclusionsThe Sjögren’s syndrome knowledge base ( http://sskb.umn.edu) can form the foundation for an informed search of existing knowledge in the field as new potential therapeutic targets are identified by conventional or high throughput experimental techniques.

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Antiphospholipid Antibody Syndrome and Autoimmune Diseases

Cited by 25 publications

References 52 publications

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Antiphospholipid-Related Chorea

Text-mining applied to autoimmune disease research: the Sjögren’s syndrome knowledge base

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