Antiphospholipid- associated recurrent chorea and ballism in a child with cerebral palsy

Okun, Michael S.; Jummani, Rahil; Carney, Paul R.

doi:10.1016/s0887-8994(00)00152-1

Cited by 23 publications

(12 citation statements)

References 4 publications

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“…[39][40][41][42] These have included Factor V Leiden deficiency, the presence of anticardiolipin or antiphospholipid antibodies, and Protein C or S deficiency. One class III study 42 and several class IV case reports [43][44][45][46] have also described the relation between neonatal cerebral infarction, coagulopathies, and a later diagnosis of hemiplegic CP.…”

Section: Coagulopathies Should Coagulation Studies Be Performed In Cmentioning

confidence: 99%

Practice Parameter: Diagnostic assessment of the child with cerebral palsy [RETIRED]

Ashwal¹,

Russman²,

Blasco³

et al. 2004

Neurology

537

327

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Abstract-Objective:The Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society develop practice parameters as strategies for patient management based on analysis of evidence. For this parameter the authors reviewed available evidence on the assessment of a child suspected of having cerebral palsy (CP), a nonprogressive disorder of posture or movement due to a lesion of the developing brain. Methods: Relevant literature was reviewed, abstracted, and classified. Recommendations were based on a four-tiered scheme of evidence classification. Results: CP is a common problem, occurring in about 2 to 2.5 per 1,000 live births. In order to establish that a brain abnormality exists in children with CP that may, in turn, suggest an etiology and prognosis, neuroimaging is recommended with MRI preferred to CT (Level A). Metabolic and genetic studies should not be routinely obtained in the evaluation of the child with CP (Level B). If the clinical history or findings on neuroimaging do not determine a specific structural abnormality or if there are additional and atypical features in the history or clinical examination, metabolic and genetic testing should be considered (Level C). Detection of a brain malformation in a child with CP warrants consideration of an underlying genetic or metabolic etiology. Because the incidence of cerebral infarction is high in children with hemiplegic CP, diagnostic testing for coagulation disorders should be considered (Level B). However, there is insufficient evidence at present to be precise as to what studies should be ordered. An EEG is not recommended unless there are features suggestive of epilepsy or a specific epileptic syndrome (Level A). Because children with CP may have associated deficits of mental retardation, ophthalmologic and hearing impairments, speech and language disorders, and oral-motor dysfunction, screening for these conditions should be part of the initial assessment (Level A). Conclusions: Neuroimaging results in children with CP are commonly abnormal and may help determine the etiology. Screening for associated conditions is warranted as part of the initial evaluation. NEUROLOGY 2004;62:851-863 Cerebral palsy (CP) can be defined as a disorder of aberrant control of movement and posture, appearing early in life secondary to a CNS lesion or dysfunction that is not the result of a recognized progressive or degenerative brain disease.1 The brain abnormality may occur pre-, peri-, or postnatally. The diagnosis of CP always involves a motor deficit and the usual presenting complaint for which medical evaluation is sought is that the child is not reaching motor milestones at the appropriate chronological age. In most

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Section: Coagulopathies Should Coagulation Studies Be Performed In Cmentioning

confidence: 99%

Practice Parameter: Diagnostic assessment of the child with cerebral palsy [RETIRED]

Ashwal¹,

Russman²,

Blasco³

et al. 2004

Neurology

537

327

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“…Chorea has been described as an isolated clinical manifestation in children with aPL or in association with SLE. [52][53][54][55] There are some data that support the association between migraine and aPL in children. 54 In addition, aPL have been reported in a series of children with partial seizures.…”

Section: Neurological Diseasesmentioning

confidence: 99%

Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations

Avčin

Cimaz

Meroni

2002

Lupus

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In recent years, antiphospholipid antibodies (aPL) and their associated clinical features have been recognized increasingly in various pediatric autoimmune and non-autoimmune diseases. Pathogenic mechanisms involved in pediatric antiphospholipid syndrome (APS) appear to be the same as in adults. However, since pediatric patients do not have prothrombotic risk factors present in adults, there clearly are differences in the spectrum of clinical findings. The frequency of aPL-related thrombotic events is generally low in pediatric populations. On the other hand, various commonly acquired infections are likely to be responsible for higher percentage of non-pathogenic and transient aPL in childhood. Such points have to be considered in clinical judgment of elevated aPL in children. In this review we summarize the recent data on the prevalence and clinical significance of aPL in neonates, children and adolescents.

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“…In patients with severe ICU chorea, EEG monitoring should be performed to rule out an epileptic cause of the movements. It is also important to consider other reversible causes of severe chorea, such as phenytoin intoxication [71] and antiphospholipid antibodies [101].…”

Section: Icu Choreamentioning

confidence: 99%

Movement disorder emergencies

Poston

Frucht

2008

J Neurol

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Movement disorder emergencies include any movement disorder which evolves over hours to days, in which failure to appropriately diagnose and manage can result in patient morbidity or mortality. It is crucial that doctors recognize these emergencies with accuracy and speed by obtaining the proper history and by being familiar with the phenomenology of frequently encountered movements. These disorders will be discussed based on the most common associated involuntary movement, either parkinsonism, dystonia, chorea, tics or myoclonus, and, when available, review the workup and treatment options based on the current literature.

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Antiphospholipid- associated recurrent chorea and ballism in a child with cerebral palsy

Cited by 23 publications

References 4 publications

Practice Parameter: Diagnostic assessment of the child with cerebral palsy [RETIRED]

Practice Parameter: Diagnostic assessment of the child with cerebral palsy [RETIRED]

Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations

Movement disorder emergencies

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