Antiphospholipid syndrome and antiphospholipid antibody profile in patients with retinal vein occlusion

Hernández, José L.; Sanlés, Iria; Pérez‐Montes, Rocío; Martínez‐Taboada, Víctor M.; Olmos, José M.; Salmón, Zaida; Sierra, Isabel; Escalante, Estefanía; Napal, J.

doi:10.1016/j.thromres.2020.04.005

Cited by 25 publications

(16 citation statements)

References 36 publications

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“…En cuanto al comportamiento del SAF en pacientes con OVR hay que destacar que esta entidad presenta unas características especiales, asociándose fundamentalmente con manifestaciones de la arteriosclerosis y no con el desarrollo de trombosis venosa profunda o embolismo pulmonar, siendo la antiagregación el tratamiento de elección 17 . Uno de nuestros pacientes presentó neumonía y 3 precisaron ingreso hospitalario.…”

Section: Discussionunclassified

Efectos de la pandemia por SARS-CoV-2 en una cohorte de pacientes con obstrucción venosa retiniana

Palacios

Ruiz

Lecumberri

et al. 2021

Revista Clínica Española

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Antecedentes y objetivos En diciembre de 2019 surgió una nueva enfermedad por coronavirus en humanos causada por el virus SARS-CoV-2, la COVID-19, que se ha asociado con fenómenos trombóticos. La obstrucción venosa retiniana (OVR) es principalmente una consecuencia de los factores de riesgo vascular (FRV). El objetivo de este estudio ha sido analizar los casos de infección por SARS-CoV-2 en una cohorte de pacientes con OVR (cohorte Valdecilla). Pacientes y métodos Entre diciembre de 2008 y 2020 hemos atendido 429 pacientes con OVR. Diez han padecido COVID-19, de los que uno no presentaba FRV ni trombofilia. Los otros 9 fueron diagnosticados de OVR antes de la infección: todos tenían FRV; 6 ateromatosis carotídea y 4 presentaban un síndrome antifosfolípido. La infección no causó en ellos fenómenos trombóticos. Conclusiones La OVR es una manifestación infrecuente de la COVID-19. En nuestra cohorte de pacientes con OVR la COVID-19 no indujo eventos trombóticos.

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Section: Discussionunclassified

Efectos de la pandemia por SARS-CoV-2 en una cohorte de pacientes con obstrucción venosa retiniana

Palacios

Ruiz

Lecumberri

et al. 2021

Revista Clínica Española

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“…It has been suggested that when retinal vascular occlusion has an unexplained background, antiphospholipid antibodies may play an important role in its pathogenesis [ 15 , 51 , 52 , 53 ]. Recently, in a case control study (331 patients with RVO and 281 controls), it was confirmed that the prevalence of antiphospholipid syndrome was higher in RVO patients than healthy subjects [ 54 ]. It seems, therefore, that screening tests detecting antiphospholipid antibodies could be useful for informing patients about a high risk of thrombosis, thus allowing early implementation of prophylaxis or even treatment [ 15 , 53 , 55 ].…”

Section: Risk Factors Of Rvo Associated With Coagulation/anticoagulation Disorders (Thrombophilia)mentioning

confidence: 98%

Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion

Marcinkowska

Cisiecki

Różalski

2021

JCM

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Retinal vein occlusion (RVO) is a heterogenous disorder in which the formation of a thrombus results in the retinal venous system narrowing and obstructing venous return from the retinal circulation. The pathogenesis of RVO remains uncertain, but it is believed to be multifactorial and to depend on both local and systemic factors, which can be divided into vascular, platelet, and hypercoagulable factors. The vascular factors include dyslipidaemia, high blood pressure, and diabetes mellitus. Regarding the platelet factors, platelet function, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) play key roles in the diagnosis of retinal vein occlusion and should be monitored. Nevertheless, the role of a hypercoagulable state in retinal vein occlusion remains unclear and requires further studies. Therefore, the following article will present the risk factors of RVO associated with coagulation disorders, as well as the acquired and genetic risk factors of thrombophilia. According to Virchow’s triad, all factors mentioned above lead to thrombus formation, which causes pathophysiological changes inside venous vessels in the fundus of the eye, which in turn results in the vessel occlusion. Therefore, a diagnosis of retinal vein occlusion should be based on both eye examination and general examination, including laboratory tests.

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“…In retinal vein occlusion, the presence of aPLs has been reported as higher compared with populationbased controls [38][39][40][41]. A recent systemic review and meta-analysis assessing the risk of retinal vein occlusion showed a significant association between aPLs and risk of developing retinal vein occlusion (OR = 5.18, 95% CI = [3.37, 7.95]) [42].…”

Section: Posterior Segmentmentioning

confidence: 99%

“…Though venous occlusion involving the eye was not specifically mentioned, given the higher prevalence of aPLs in patients with retinal vein occlusion [38][39][40][41] and increased risk of developing of retinal vein occlusion in the presence of aPLs [42,44,45] that has been reported in several studies, aPLs are potential targets to detect and measured in patients with newly diagnosed retinal vein occlusion, especially in patients without any known systemic underlying conditions such as hypertension, diabetes, hyperlipidemia, and cardiovascular disease.…”

Section: Posterior Segmentmentioning

confidence: 99%

Current concepts in the diagnosis and management of antiphospholipid syndrome and ocular manifestations

Uludağ

Onghanseng

Tran

et al. 2021

J Ophthal Inflamm Infect

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Antiphospholipid syndrome (APS) is an autoimmune disorder associated with obstetrical complications, thrombotic complications involving both arteries and veins, and non-thrombotic manifestations affecting multiple other systems presenting in various clinical forms. Diagnosis requires the presence of antiphospholipid antibodies. The exact pathogenesis of APS is not fully known. However, it has recently been shown that activation of different types of cells by antiphospholipid antibodies plays an important role in thrombosis formation. Ocular involvement is one of the important clinical manifestations of APS and can vary in presentations. Therefore, as an ophthalmologist, it is crucial to be familiar with the ocular findings of APS to prevent further complications that can develop. Furthermore, the ongoing identification of new and specific factors contributing to the pathogenesis of APS may provide new therapeutic options in the management of the disease in the future.

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Antiphospholipid syndrome and antiphospholipid antibody profile in patients with retinal vein occlusion

Cited by 25 publications

References 36 publications

Efectos de la pandemia por SARS-CoV-2 en una cohorte de pacientes con obstrucción venosa retiniana

Efectos de la pandemia por SARS-CoV-2 en una cohorte de pacientes con obstrucción venosa retiniana

Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion

Current concepts in the diagnosis and management of antiphospholipid syndrome and ocular manifestations

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