Antiphytovirale Verbindungen mit nichtzyklischer Azin Struktur

Abstract

Antiphytoviral compounds with noncyclic azine structutre The antiphytoviral activities of variously substituted compounds with noncylic azine structures have been studied f a total of 90 tested compunds 42 had the effect of more or less strong inhibiting the concentration of potato virus X (PVX) in inoculated and / or secondarily infected leaves of Nicotiana tabacum L. cv Samsun (Table.1) An effect on the virion of PVX in vitro couldn't be observed (Table.2) Thus the substances may interact with the virus replication. Some of them also reduced the number of local lesions caused by tabacco mosaic virus on leaves of Nicotiana glutinosa L. (Table‐3) Several Compounds proved exellent synergists of 2,4‐ dioxohexahydro‐ 1,3,5‐ triazine (DHT = 5 azadihydrouracil; Table 4) Pyridine‐ 3‐ aldehyde S ethyl isothiosemicarbazone and the Cu complex of 1‐ ethyl‐isatine S‐ ethyl isothisosemicarbazone when used in combination with 2,4 dioxohexahydro‐ 1,3,5, triazine, greatly increased the mass of potato tubers produced from plantlets grown up from patato eye cutting as compared with the indentical control Simultaneously the mentioned substances reduced the number of symptom bearing eye cutting plants Quinoline 2‐ aldehyde‐ N‐ oxide S‐ allyl‐isothiosemicarbazone had the effect of very greatly reducing the number of symptom‐bearing plants without substantially influencing the mass of tubers (Table 5). Thus some compounds with noncyclic azine structure especially when used in combinitation with DHT, may be of high interest for practical application Comparing the structures of compounds with noncyclic azine structure active against plant or human viruses it should be noted that antiphytoviral compounds active in these two different virus host systems often are closely related structurally.

Experimental and theoretical investigations of copper (I/II) complexes with triazine–pyrazole derivatives as ligands and their in situ C–N bond cleavage

“…antiphytovirucide [1][2][3][4]. Especially, some derivatives can be used as potential functional materials in the fields of magnetic, optical, catalyst, and liquid crystal materials [5][6][7][8][9][10].…”

Synthesis and antivirus activity of 1,3,5‐triazine derivatives

“…1,3,5-Triazines have attracted attention because of their marked antivirus activities [1][2][3][4]. 2,4-Dioxohexahydro-1,3,5-triazine (DHT) and 1,5-diacetyl-2,4-dioxohexahydro-1,3,5-triazine (DADHT) have been commercialized as plant virucides [5][6][7][8].…”

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ABSTRACT: 3,triazine-2-one with alkyl halide in the presence of 1 equiv. of sodium hydroxide resulted in 4-alkylthio-6-phenyl-1,3,5-triazine-2-one in good yield, whereas the above reaction provided 2-alkoxyl-4-alkylthio-6-phenyl-1,3,5-triazine

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