Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum

Wangchuk, Phurpa; Bremner, John B.; Samten, -; Skelton, Brian W.; White, Allan H.; Rattanajak, Roonglawan; Kamchonwongpaisan, Sumalee

doi:10.1016/j.jep.2010.05.057

Cited by 31 publications

(11 citation statements)

References 22 publications

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“…On the other hand, otostegindiol (25, 50, and 100 mg/kg) against Plasmodium berghei exhibited a significant chemosuppression effect (Endale et al, 2013). It should be mentioned that, till date, a number of promising diterpenes and their derivatives have been isolated from natural sources (Pouvelle et al, 1994;Uys et al, 2002;Riel et al, 2002;Kuria et al, 2002;Köhler et al, 2002;Clarkson et al, 2003;Wei et al, 2004;Loyola et al, 2004;Ospina et al, 2005;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Koka et al, 2009;Lane et al, 2009;Wei et al, 2010;Lin et al, 2010;Wangchuk et al, 2010;Stout et al, 2010;Sebisubi et al, 2010;Stout et al, 2011;Cocquyt et al, 2011;Alasbahi and Melzig, 2012;Ebrahimi et al, 2013;Ehrhardt et al, 2013;Walter et al, 2013;Batista et al, 2013;González et al, 2014;Ma et al, 2014;Avilés et al, 2015;Gbedema et al, 2015;Annan et al, 2015;Sadashiva et al, 2015;Namukobe et al, 2015;Ahmad et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…In some studies, diterpenes in nanoformulations (Roy et al, 2010;Mondal et al, 2013) as well as their laboratory derivatives have been reported to exhibit promising anti-NTDs activities (Watson and Preedy, 2010;Mander and Liu, 2010). Additionally, a number of diterpenes have been reported to act against multiple strains responsible for a particular NTD (Sanchez et al, 2006;Dea-Ayuela et al, 2016;Johnson et al, 1993;Riel et al, 2002;Clarkson et al, 2003;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Wangchuk et al, 2010;González et al, 2014;Namukobe et al, 2015;Liu et al, 1997;Prabu et al, 2015;Encarnación-Dimayuga et al, 2006;Rijo et al, 2010;Arai et al, 2014;Xu et al, 2014a;Xu et al, 2014b) and NTDs (Schmidt et al, 2011;Al Musayeib et al, 2014;Ramírez-Macías et al, 2012;Mothana et al, 2014;Falodun et al, 2014;Mizuno et al, 2015;Mongkolvisut and Sutthivaiyakit, 2007;Rangkaew et al, 2009;Ospina and Rodríguez, 2009;Lekphrom et al, 2010;Almutairi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs. For this, databases were searched using specific search terms. Among the 2338 collected reports, a total of 181 articles were included in this review. Of them, 148 dealt with investigations using single organisms, and 33 used multiple organisms. No mechanisms of action were reported in the case of 164 reports. A total of 93.92% were related to nonclinical studies, and 4.42% and 1.66% dealt with preclinical and clinical studies, respectively. The review displays that many diterpenes are effective upon Chagas disease, chikungunya, echinococcosis, dengue, leishmaniasis, leprosy, lymphatic filariasis, malaria, schistosomiasis, and tuberculosis. Indeed, diterpenes are amazing drug candidates against NTDs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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“…Three new and two known diterpenoid alkaloids were discovered from A. orochryseum [31] and one of these alkaloids, atisinium chloride was identified as the drug lead compound against the multi-drug resistant Plasmodium falciparum malaria [32]. Similarly, four known isoquinoline alkaloids with antimalarial activities were isolated from C. calliantha where cheilanthifoline showed best in vitro activities against the P. falciparum chloroquine and antifolate sensitive TM4 strain with IC 50 values of 0.90 μg/mL and multi-drug resistant K1 strain with IC 50 values of 1.22 μg/mL [33].…”

Section: Resultsmentioning

confidence: 99%

Contributions of medicinal plants to the Gross National Happiness and Biodiscovery in Bhutan

Wangchuk

Tobgay

2015

J Ethnobiology Ethnomedicine

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BackgroundThe medicinal plants and the associated Bhutanese traditional medicine (BTM) are protected by the country’s constitution and receive both government support and acceptance by the wider public. More than 1000 medicinal plants are described in the BTM but currently collects only 300 species for daily formulations of BTM. These medicinal plants have been one of the drivers of the ‘Gross National Happiness (GNH)’ and biodiscovery projects in Bhutan. However, no review covering the systematic evaluations of the contributions of medicinal plants and the BTM to the GNH and biodiscovery exist till date.MethodsThis paper, therefore addresses this information gap. It is based on the review of the existing traditional and scientific literature, government websites and policy documents. The descriptions and discussions of the paper is straightened, authenticated and enhanced by the data collected through the informal discussions with the BTM practitioners and also through the authors’ many years of practical observations of the impact of the medicinal plants programs and the BTM practices in Bhutan.ResultsThis paper found the following: a) the medicinal plants generates income to the farmers elevating their living standard and the economic status, b) it serves as the bulk ingredients of the BTM facilitating the provision of free traditional health care services to the patients, c) helps the conservation of medicinal plants and their pristine environment through recognition of their spiritual, social and economic values, d) preserves the rich BTM cultural heritage, and e) guides the biodiscovery projects based on their ethnobotanical information. The paper also identified the challenges and research gaps, and recommends appropriate strategies that can help secure the sustainable future of the medicinal plants, the BTM and the biodiscovery projects.ConclusionsThe medicinal plants play significant role in the country’s biodiscovery projects and the internationally renowned development policy of ‘Gross National Happiness’.

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“…Therefore, with the aim of generating good scientific data to assist this cause, we have recently engaged in studies of selected medicinal plants used in BTM. The findings in terms of ethnobotanical identification, phytochemical content and biological activity studies were previously reported (Wangchuk et al, 2007b(Wangchuk et al, , 2010a(Wangchuk et al, , 2010b(Wangchuk et al, , 2011a(Wangchuk et al, , 2011b(Wangchuk et al, , 2012a(Wangchuk et al, , 2012b.These studies required us to first gain an intimate understanding of the BTM, its materia medica, pharmacopoeia, concepts, ethnoquality, medicinal plants and its current practices in Bhutan. Therefore, we studied the BTM methods, traditional literature, current BTM practices, BTM practitioners' views and analyzed them with a modern scientific perspective.…”

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confidence: 76%

An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: Textual understanding and the current practices

Wangchuk

Pyne

Keller

2013

Journal of Ethnopharmacology

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Ethnopharmacological relevance : This study involves the assessment of the Bhutanese traditional medicine (BTM) which was integrated with the mainstream biomedicine in 1967 to provide primary health care services in the country. It caters to 20-30% of the daily out-patients within 49 traditional medicine units attached to 20 district modern hospitals and 29 Basic Health Units in the country. Aim of the study : This study presents the ethnopharmacological, ethnobotanical and the ethnoquality concepts in relation to mainstream Tibetan medicine and describes the current practices of BTM. Materials and methods : Experienced BTM practitioners (Drung-tshos and Smen-pas) were selected using a convenience sampling method and were interviewed using an open questionnaire followed by informal discussions. The corpus of BTM, Tibetan and scientific literature was obtained and the information on ethnopharmacological, ethnoquality and ethnobotanical concepts and current practices of BTM was extracted. Results : This study found that the BTM shares many similarities in terms of materia medica, pharmacopoeia and the principles and concepts of ethnopharmacology and ethnobotany with its mainstream Tibetan medicine. However, the resourceful Bhutanese Drung-tshos and Smen-pas have adapted this medical system based on the local language, culture, disease trend, health care needs and their familiarity with the locally available medicinal ingredients making it particular to the country. A number of notable distinctions observed in the current practices include a code of classification of diseases (only 79 of 404 types of disorders recognized), formulations (currently used only 103 of thousands formulation types), usage of medicinal plants (only 229 species of thousands described) and selected treatment procedures (golden needle and water therapy). This BTM was found to cater to 20-30% of daily out-patients visiting 49 modern hospitals and basic health units in the country. Conclusions : The BTM has been evolved from the Tibetan medicine. While the pharmacopoeia, ethnopharmacology, ethnobotany and the ethnoquality aspects shares commonalities with the mainstream Tibetan medicine, there are some practices unique to BTM. Such uniqueness observed in the current practices of BTM include formulations, medicinal plants collection and usage, and the treatment procedures including golden needle and water therapy. This could be a promising source of information for the rediscovery of useful remedies, the development of modern phytotherapeutics and the establishment of efficient quality control measures.Keywords bhutanese, assessment, understanding, textual, ethnoquality, ethnobotany, ethnopharmacology, practices, its, current, medicine, traditional Since BTM plays a significant role in the primary health care services of the country, the Ministry of Health in Bhutan emphasizes the improvement of the quality, safety and efficacy of its medicine through scientific studies. Therefore, with the aim of generating good scientific data to ass...

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Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum

Cited by 31 publications

References 22 publications

Diterpenes as lead molecules against neglected tropical diseases

Diterpenes as lead molecules against neglected tropical diseases

Contributions of medicinal plants to the Gross National Happiness and Biodiscovery in Bhutan

An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: Textual understanding and the current practices

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