Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon

Boyom, Fabrice Fekam; Kemgne, Eugénie Madiesse; Tepongning, Roselyne Nzangue; Ngouana, Vincent; Mbacham, Wilfred Fon; Tsamo, Etienne; Zollo, Paul Henri Amvam; Gut, Jiří; Rosenthal, Philip J.

doi:10.1016/j.jep.2009.03.008

Cited by 57 publications

(42 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activity varied greatly among parasite isolates. The fresh P. falciparum isolates were 10-20-fold more sensitive to the tested fractions, compared to the results obtained by Boyom et al (2009) with the same extracts against the W2 reference strain. They were comparable to the findings of Sanon et al (2003), who described similar variability of results from the assessment of the antiplasmodial activity of alkaloid extracts from Pavetta crassipes and Acanthospermum hispidum growing in Burkina Faso against parasite isolates.…”

Section: Antiplasmodial Activity Of Plant Extracts and Combinationsmentioning

confidence: 79%

“…Similar preparations using the barks of P. oliveri and U. congolana are also used in malaria treatment in some localities. Previous studies indicate that methanolic, water, and ethanolic extracts, as well as purified alkaloids from the stem bark of E. chlorantha showed interesting antiplasmodial activities in vitro and in vivo (Boyom et al 2009;Vennerstrom and Klayman 1998;Adjanohoun et al 1996;Kimbi and Fagbenro-Beyioku 1996;Agbaje andOnabanjo 1994, 1991;Agomo et al 1992). Apart from the findings of (2009), few studies were described on P. oliveri.…”

Section: Plant Selection and Collectionmentioning

confidence: 98%

“…Uvariopsis is an African-specific genus that has been reported to produce acetogenins. To the best of our knowledge, the only reported study on U. congolana is that of Boyom et al (2009). A related species (Uvariopsis congensis) that is reported to be eaten by wild chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park, western Uganda has also been investigated.…”

Section: Plant Selection and Collectionmentioning

confidence: 99%

“…Air-dried and ground plant materials (500 g) were extracted according to Alali et al (1999) with a few modifications as described by Boyom et al (2009) to prepare acetogeninrich fractions. After submitting the plant materials to 95% ethanol extraction for 48 h, the resulting ethanolic residues were partitioned between H 2 O and CH 2 Cl 2 , leading to H 2 O layers and CH 2 Cl 2 layers.…”

Section: Plant Extraction and Partitionmentioning

confidence: 99%

“…According to Boyom et al (2009), the antimalarial potency of these fractions is most likely attributable to acetogenins. Indeed, acetogenins have been shown to be the most powerful of the known inhibitors of complex I (NADH: ubiquinone oxidoreductase) in mitochondrial electron transport systems (Lewis et al 1993); in addition, they are potent inhibitors of NADH oxidase of plasma membranes (Morré et al 1995).…”

Section: Antiplasmodial Activity Of Plant Extracts and Combinationsmentioning

confidence: 99%

See 4 more Smart Citations

In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

et al. 2011

Self Cite

View full text Add to dashboard Cite

In a search for new plant-derived antimalarial extracts, 19 fractions were obtained from three Annonaceae species, Uvariopsis congolana (leaf, stem), Polyalthia oliveri (stem bark), and Enantia chlorantha (stem, stem bark) with yields ranging from 0.33% to 4.60%. The extracts were prepared from 500 g of each plant part, using organic solvents to afford five methanolic fractions (acetogenin rich), five water fractions, five hexane fractions, and four interface precipitates. Evaluation of the activity of fractions in vitro against field isolates of the malaria parasite Plasmodium falciparum showed that acetogenin-rich fractions and interface precipitates were the most potent, with IC(50) values ranging from 0.05 to 8.09 μg/ml. Sensitivity of parasite isolates to plant extracts varied greatly, with over 100-fold difference from isolate to isolate in some cases. The active acetogenin-rich fractions and interface precipitates were assessed in combination with chloroquine in the same conditions, and showed additive interaction in the huge majority of cases. Synergistic interactions were found in some cases with acetogenin-rich fractions. Acute toxicity of promising fractions was evaluated through oral administration in Swiss albino mice. Tested fractions appeared to be safe, with LD(50) values higher than 2 g/kg. In summary, acetogenin-rich fractions from Annonaceae species showed high potency against P. falciparum field isolates and safety by oral administration in mice, supporting their detailed investigation for antimalarial drug discovery.

show abstract

Section: Antiplasmodial Activity Of Plant Extracts and Combinationsmentioning

confidence: 79%

Section: Plant Selection and Collectionmentioning

confidence: 98%

Section: Plant Selection and Collectionmentioning

confidence: 99%

Section: Plant Extraction and Partitionmentioning

confidence: 99%

Section: Antiplasmodial Activity Of Plant Extracts and Combinationsmentioning

confidence: 99%

See 3 more Smart Citations

In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

Composition and Chemical Variability of Ivoirian Polyalthia oliveri Leaf Oil

Ouattara

Boti

Ahibo

et al. 2016

Chemistry & Biodiversity

View full text Add to dashboard Cite

The chemical composition of 45 essential oil samples isolated from the leaves of Polyalthia oliveri harvested in three Ivoirian forests was investigated by GC-FID (retention indices measured on two columns of different polarities), and by (13) C-NMR, following a method developed in our laboratory. In total, 41 components were identified. The content of the main components varied drastically from sample to sample: (E)-β-caryophyllene (1.2 - 50.8%), α-humulene (0.6 - 47.7%), isoguaiene (0 - 27.9%), alloaromadendrene (0 - 24.7%), germacrene B (0 - 18.3%), δ-cadinene (0.4 - 19.3%), and β-selinene (0.2 - 18.5%). The analysis of six oil samples selected in function of their chromatographic profiles is reported in detail. The 45 oil compositions were submitted to hierarchical cluster and principal components analysis, which allowed the distinction of three groups within the oil samples. The compositions of the oils from group I (15 samples) and II (12 samples) were dominated by (E)-β-caryophyllene and α-humulene, respectively. Oil samples of group III (18 samples) needed to be partitioned into four subgroups III.1-III.4 whose compositions were dominated by alloaromadenrene, isoguaiene, germacrene B, and δ-cadinene, respectively.

show abstract

Drug Discovery in Africa

Chibale¹,

Davies‐Coleman²,

Masimirembwa³

2012

View full text Add to dashboard Cite

The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

show abstract

Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon

Cited by 57 publications

References 37 publications

In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

Composition and Chemical Variability of Ivoirian Polyalthia oliveri Leaf Oil

Drug Discovery in Africa

Contact Info

Product

Resources

About