Antiplasmodial activity of flavonoids from <i>Macaranga tanarius</i> leaves

Marliana, Eva; Hairani, Rita; Tjahjandarie, Tjitjik; Tanjung, Mulyadi

doi:10.1088/1755-1315/144/1/012011

Cited by 8 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Resultsmentioning

confidence: 99%

“…Two known flavanones, lonchocarpol A (2) and nymphaeol C (3), separated from fraction A, showed the chemical shift values (δ H and δ C ) in the NMR spectrum of the same compounds originating from Erythrina crista-galli L. and M. tanarius. 9,17 The antiplasmodial activity of flavanones 1-3 toward P. falciparum 3D7 was assayed using Trager and Jensen's method (Table 2). These results show that compounds 1-3 potentiate against P. falciparum 3D7.…”

Section: Antiplasmodial Assaymentioning

confidence: 99%

“…Chalcones, dihydrochalcones, flavones, flavanones, flavonols, and dihydroflavonols are generally found in the leaves. Flavanones and flavonols are the major flavonoids often found in Macaranga plants and exhibit antimalarial, anticancer, and antioxidant activities 8–13 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Macahuilettiin A, a new isoprenylated flavanone from the leaves of Macaranga hullettii King ex Hook and their antiplasmodial activity

Saputri,

Tukiran,

Wati

et al. 2024

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

A new isoprenylated flavanone, macahuilettiin A (1), along with lonchocarpol A (2) and nymphaeol C (3), were isolated from Macaranga hullettii King ex Hook leaves. Their structures were combined by UV, high‐resolution ESI‐TOFMS, 1D‐, and 2D‐NMR spectra analysis. Flavanones 1–3 were assayed for antiplasmodial activity toward Plasmodium falciparum 3D7, which was carried out using the Trager and Jansen method, showing that the IC50 values for flavanones 1–3 were 0.15, 1.64, and 0.61 µm, respectively, which is classified as high activity.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Antiplasmodial Assaymentioning

confidence: 99%

See 1 more Smart Citation

Macahuilettiin A, a new isoprenylated flavanone from the leaves of Macaranga hullettii King ex Hook and their antiplasmodial activity

Saputri,

Tukiran,

Wati

et al. 2024

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…Free heme (Fe3+) sangat toksik karena dapat menyebabkan spesies oksigen sangat reaktif yang dapat memicu reaksi oksidatif sehingga parasit mati. 21 Berdasarkan temuan-temuan yang telah dipaparkan, dapat membuktikan bahwa terdapat banyak tumbuh-tumbuhan herbal yang memiliki efek sebagai antimalaria pada Plasmodium berghei seperti ekstrak daun jati sabrang (Peronema canescens), tumbuhan berbunga Asteraceae dan Rubiaceae families, daun bunga nusa indah (Mussaenda erythrophylla), daun nyamplung (Calophyllum flavoranulum), daun kedondong hutan (Spondias pinnata), dan kulit batang gambilo (Gardenia ternifolia). Kandungan zat-zat alami yang ditemukan pada tumbuhan herbal tersebut seperti alkaloid, terpen, antrakuinon, flavonoid, tannin, saponin, dan steroid juga ditemukan pada ekstrak daun sirih hijau (Piper betle L) yang terbukti sebagai antimalaria.…”

Section: Pembahasanunclassified

Uji Efektivitas Kombinasi Ekstrak Daun Sirih Hijau “Piper Betle L” Dan Madu Sebagai Antimalaria Pada Mencit Yang Diinfeksi Plasmodium Berghei

Swastika,

Sri Laksemi,

Damayanti

et al. 2023

eum

View full text Add to dashboard Cite

Malaria is an infectious disease caused by the parasite Plasmodium sp. transmitted by the female Anopheles mosquito vector through its bite. Patients infected with malaria worldwide in the last two decades have increased, mainly due to the emergence of strains of Plasmodium falciparum that have become resistant to antimalarial drugs. This has resulted in the emergence of efforts to find alternative medicinal plants that can overcome this problem. One of the plants that have the potential to be developed is Piper betle L, or commonly known as green betel plant. This study aims to determine the effect of green betel leaf extract (Piper betle L) and honey at doses of 50, 100, and 200 mg/kgBW as antimalarials in Balb/c mice infected with Plasmodium berghei. This study is an in vivo experimental study using the Randomized Post-test Only Controlled Group method design using 24 samples of mice which were divided into four groups, one negative control group and three treatment groups. The average degree of parasitemia in the control group was 45.51%, the treatment group at a dose of 50 mg/kgBW was 35.71%, a dose of 100 mg/kgBW was 30.96% and a dose of 200 mg/kgBW was 31.67%. Based on the results of the analysis using One Way ANOVA, it was found that the mean difference between the control and treatment groups with p value <0.001 was found. The results showed that green betel leaf extract (Piper betle L) could inhibit the growth of Plasmodium berghei by looking at the mean difference between the control group and the treatment group and obtained that the average treatment group of 100 mg/kgBW and 200 mg/kgBW were equally effective at inhibiting parasitemia levels. Keywords : Antimalarial, Piper betle L, Degree of Parasitemia

show abstract

“…Propolin D, a prenylated flavanone extracted from the fruits of species, was found to have antibacterial and antifungal properties (Lee et al 2019). Antiplasmodial activity has also been reported due to the presence of flavonoid content (Marliana et al 2018). Stilbenes isolated from glandular trichomes of fruits show cytotoxic activity against mouth epidermal carcinoma cells as well as breast cancer cells (Doan et al 2019).…”

Section: Phytochemistrymentioning

confidence: 99%

Macaranga tanarius (L.) Müll.Arg. Euphorbiaceae

Mustaqim¹

2020

Ethnobotany of Mountain Regions

View full text Add to dashboard Cite

Local NamesIndonesia: binunga (Sangir in Sulawesi); dahan (Alf. Minahasa); hanuwa (Ambon and Seram); hinan, lama (Ambon); karahan, tutup, tutup ancur, waru laut (Javanese); kayu mata putih (Atinggola in Gorontalo); kemahang putih (Bengkalis in Riau); lapi (Kolaka Timur and Buton in Sulawesi); mara (Sundanese); madau (Lampung); mapu (Batak); mombeti (Sigi in Sulawesi); ndenu (East Luwu in Sulawesi); rebak (Manggarai in Flores); same (Lako Akediri in Halmahera); sapat (Serampas in Jambi); seribu guna (Pidie in Aceh); surok (Krui in Lampung); totop lakèk (Madura); tubi tahak (Tetun in West Timor); tutup (Kerinci in Central Sumatra); umera (Wungkolo in Wawonii, Southeast Sulawesi). Malaysia: inchong, jebat musang, kundoh, mahang puteh, tampu, tampu hitam, tampu puteh; daun bayangan (Murut, Sabah); mahang putih (Ulu, Sarawak).

show abstract

Antiplasmodial activity of flavonoids from Macaranga tanarius leaves

Cited by 8 publications

References 8 publications

Macahuilettiin A, a new isoprenylated flavanone from the leaves of Macaranga hullettii King ex Hook and their antiplasmodial activity

Macahuilettiin A, a new isoprenylated flavanone from the leaves of Macaranga hullettii King ex Hook and their antiplasmodial activity

Uji Efektivitas Kombinasi Ekstrak Daun Sirih Hijau “Piper Betle L” Dan Madu Sebagai Antimalaria Pada Mencit Yang Diinfeksi Plasmodium Berghei

Macaranga tanarius (L.) Müll.Arg. Euphorbiaceae

Contact Info

Product

Resources

About