Antiplasmodial activity of four Kenyan medicinal plants

Omulokoli, E.; Khan, Baldip; Chhabra, S. C.

doi:10.1016/s0378-8741(97)01521-3

Cited by 175 publications

(106 citation statements)

References 9 publications

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“…Alkaloids isolated from plant are commonly found to have antimicrobial properties (Omulokoli et al, 1997). Alkaloids may be useful against HIV infection (Sethi, 1979) as well as intestinal infections associated with AIDS (McDevitt et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq

Al-Bayati

Al-Mola

2008

J. Zhejiang Univ. Sci. B

144

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Section: Discussionmentioning

confidence: 99%

Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq

Al-Bayati

Al-Mola

2008

J. Zhejiang Univ. Sci. B

144

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“…Virtually all drugs for malaria such as chloroquine, quinine, sulphadoxine-pyrimethamine, and artemisinin combined therapies (ACTs) have developed resistance against Plasmodium parasites (Jambou et al, 2005). Therefore, to effectively manage malaria, new knowledge, products, and tools are urgently needed and particularly new drugs (Omulokoli et al, 1997). An effective malaria vaccine would be the most powerful and most cost-effective measure with a potential long-term impact including the possibility of eradicating the disease.…”

Section: Introductionmentioning

confidence: 99%

Brine shrimp cytotoxicity and antimalarial activity of plants traditionally used in treatment of malaria in Msambweni district

Mwangi

Wagacha

Nguta

et al. 2014

Pharmaceutical Biology

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Context: In Kenya, most people use traditional medicine and medicinal plants to treat many diseases including malaria. To manage malaria, new knowledge and products are needed. Traditional herbal medicine has constituted a good basis for antimalarial lead discovery and drug development. Objectives: To determine in vivo antimalarial activity and brine shrimp toxicity of five medicinal plants traditionally used to treat malaria in Msambweni district, Kenya. Materials and methods: A 0.2 ml saline solution of 100 mg/kg aqueous crude extracts from five different plant parts were administered orally once a day and evaluated for their in vivo chemosuppressive effect using Plasmodium berghei berghei-infected Swiss mice for four consecutive days. Their safety was also determined using Brine shrimp lethality test: Grewia trichocarpa Hochst ex A. Rich Results: Parasitaemia was as follows: A. indica, 3.1%; D. cinerea, 6.3%; T. indica, 25.1%; A. seyal, 27.8%; and G. trichocarpa, 35.8%. In terms of toxicity, A. indica root bark extract had an LC 50 of 285.8 mg/ml and was considered moderately toxic. T. indica stem bark extract and G. trichocarpa root extract had an LC 50 of 516.4 and 545.8 mg/ml, respectively, and were considered to be weakly toxic while A. seyal and D. cinerea root extracts had a LC 50 41000 mg/ml and were, therefore, considered to be non-toxic. Discussion and conclusion: All extracts had antimalarial activity that was not significant compared to chloroquine (p ! 0.05). No extract was toxic to the arthropod invertebrate, Artemia salina L. (Artemiidae) larvae, justifying the continued use of the plant parts to treat malaria.

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“…It suggests that the selected seaweeds can be used as antiviral, antibacterial, antiparasitic agents and exercise to treat the diseases like ulcer, gonnorrhoea, leucorrhoea after clinical screening. Alkaloids are commonly found to have antimicrobial properties 36 against both Grampositive and Gram-negative bacteria 37 . In the present study also, alkaloids presence were confirmed in chloroform, acetone and ethanolic extracts by the qualitative analysis described by Harborne.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Studies on Laurencia Obtusa (Hudson) Lamourux

Antonisamy

Babu

Janakiraman

et al. 2012

Int J of Biomed & Adv Res

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Aim: The present study was aimed to explore the phytochemical constituents present in Laurencia obtusa collected from Tamil Nadu, South India. Methods: Phytochemical screening of different extracts was carried out using the standard procedure and the results were illustrated. Results: Steroids show the maximum (4/6) presence in acetone, benzene, chloroform and petroleum ether extracts followed by alkaloids (3/6) in ethanol, acetone and chloroform extracts. The UV-Vis phytochemical profile of various extracts of L. obtusa was tabulated. The qualitative HPLC fingerprint profile of ethanolic extract of L. obtusa was selected at a wavelength of 254 nm due to sharpness of the peaks and proper baseline. The profile displayed one prominent peak at a retention time of 1.953 min and some moderate peaks were observed at a retention time of 3.000, 2.570 and 2.467 min respectively. Conclusion:The present studies on L. obtusa produced novel phytochemical markers in standardization as useful analytical tools to check not only the quality of the powder but also the presence of adulterants in ayurvedic drugs.

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Antiplasmodial activity of four Kenyan medicinal plants

Cited by 175 publications

References 9 publications

Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq

Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq

Brine shrimp cytotoxicity and antimalarial activity of plants traditionally used in treatment of malaria in Msambweni district

Phytochemical Studies on Laurencia Obtusa (Hudson) Lamourux

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