Antiplasmodial activity of nanoparticles enhanced chloroquine on <i>Plasmodium berghei</i> in vivo

Abstract

The search for new antimalarial agents is at the forefront for the global fight against antimalarial drug resistance as malaria treatments take longer than the three days plan. These changes pose a threat to the progress made thus far and search for newer and more rapid antimalarial agents is needed to maintain that success. The potentials of Magnesium Oxide Nanoparticles (MgO NPs) enhanced Chloroquine were assessed on vivo. Magnesium Oxide Nanoparticles were synthesized using sol characterized using TEM (transmission electron microscope) and EDS (energy dispersive x spectroscope), SEM, UV-VIS and FTIR. Concentration of 10 mg/ml of MgO NPs were prepared and combined with graded doses of chloroquine (25mg, 12.5mg and 6.25mg per kg) and assayed on Plasmodium berghei Department Aminu Kano Teaching Hospital (AKTH) and weighed before the start of the experiment. Plasmodium berghei mice from a donor. The mice were grouped into five A, B, C, D and E consist Group A-no treatment, Group B NPs and 25mg chloroquine and Group D were treated with 10mg/ml MgO NPs and 12.5mg chloroquine and group E-10mg/ml MgO NPs and 6.25mg of chloroquin TEM shows that the particles are all under 100nm cylindrical and spherical in shape. EDS shows that the sample contains magnesium and oxygen in the ratio of 2:1. In plasmodial activity shows that all the groups that were had better parasite clearance rate (F all counts chloroquine enhanced with MgO NPs is considered to be more effective. The T shows that there is statisticall will inform malaria agencies of the potentials of this promising agent in the treatment of Plasmodium infection and further studies be carried out on the said compound.