Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum

Onegi, Bernardina; Kraft, Carola; Köhler, Inga; Freund, Marion; Jenett‐Siems, Kristina; Siems, Karsten; Beyer, G.; Melzig, Matthias F.; Bienzle, Ulrich; Eich, Eckart

doi:10.1016/s0031-9422(02)00072-9

Cited by 81 publications

(59 citation statements)

References 14 publications

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“…The roots and leaves have been found useful in treating venereal diseases, respiratory ailments, gastritis (Gill, 1992) and a disease called "Rana" with symptoms of haematuria (Dalziel, 1955). Previously, the antiplasmodial activities of naphthaquinones and one anthraquinone from the lipophilic root bark extract was reported (Onegi et al, 2002). Antidiarrhoeal (Ching et al, 2008), analgesic activities of stem bark (Ching et al, 2009), as well as the anthelmintic activity of ethanol leave extract has been reported (Monglo et al, 2006).The present study therefore, reports the phytochemical screening and antibacterial activity of the lipophilic leaves extract of Stereospermum kunthianum with a view to understanding the molecular basis of some of its therapeutic uses in traditional medicine, which had not been investigated hitherto.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antibacterial Properties of Leaf Extract of Stereospermum kunthianum (Bignoniaceae)

Hanwa¹,

Mohammed²,

Aliyu³

et al. 2010

Nig J Bas App Sci

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ABSTRACT:Phytochemical screening and studies on antibacterial activity of leave extract of Stereospermum kunthianum -a plant widely used by traditional medical practitioners in Northern Nigeria, were carried out on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella spp, Salmonella spp and Aeromonas hydrophila using agar well diffusion technique. Preliminary phytochemical screening revealed the presence of sterols, coumarins, higher fatty acids and the absence of flavones aglycone and alkaloids in the leave extract. were observed on P. aeruginosa. The spectra of activities displayed by the extract can be attributed to the presence of these phytochemicals which signifies the potential of S. Kunthianum as a source of therapeutic agents. This therefore, supports the traditional medicinal use of S. kunthianum in Zaria, Nigeria.

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Section: Introductionmentioning

confidence: 99%

Phytochemical and Antibacterial Properties of Leaf Extract of Stereospermum kunthianum (Bignoniaceae)

Hanwa¹,

Mohammed²,

Aliyu³

et al. 2010

Nig J Bas App Sci

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“…The efficacy of its water extract in human complement system fixation in-vitro has been reported [3]. The antiplasmodial activity of naphthoquinones and one anthraquinone from the lipophilic extract of the root bark of the plant has also been reported [4]. We recently reported the antidiarrhoeal activity of the aqueous extract of its stem bark in in-vivo experimentallyinduced diarrhoeal models using mice and rats [5].…”

Section: Introductionmentioning

confidence: 99%

Antidiarrhoeal Activity of Chromatographic Fractions of Stereospermum kunthianum Cham Sandrine Petit (Bignoniaceae) Stem Bark

Ching¹,

Okpo²,

Falodun³

et al. 2010

Trop. J. Pharm Res

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“…The efficacy of the water extract of Stereospermum kunthianum in human complement system fixation in-vitro has been reported (Drissa et al, 2002). Antiplasmodial activity of naphthoquinones and one anthraquinone from the lipophilic extract of the root bark of Stereospermum kunthianum has also been reported (Onegi et al, 2002). The present study was aimed at investigating the anticonvulsant activity of the aqueous stem bark extract of Stereospermum kunthianum in order to establish pharmacological evidence of its folkloric use in the management of childhood convulsions.…”

Section: Introductionmentioning

confidence: 94%

Aqueous stem bark extract of <i>Stereospermum kunthianum </i> (cham, sandrine petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents.

Ching¹,

Omogbai²,

Otokiti³

2010

Afr. J. Trad. Compl. Alt. Med.

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Stereospermum kunthianum, Cham Sandrine Petit (Bignoniaceae) known in English as pink jacaranda is used in traditional medicine to treat an array of ailments including febrile convulsions in infants and young children by the rural dwellers in Nigeria. This study examined the anticonvulsant activity of its aqueous stem bark extract (100 -400mg/kg) against maximal electroshock and pentylenetetrazole-induced seizures in rodents. Phenobarbitone and ethosuximide were used as reference anticonvulsant drugs for comparison. Stereospermum kunthianum extract (200 -400mg/kg, i.p.) remarkably protected (76.9% and 84.6 % respectively) the rats against electroshock-induced seizures. However, the extract (200-400mg/kg) when administered orally showed a comparatively less effect (33.3% and 55.6% respectively) to the intraperitoneally administered extract in the maximal electroshock test. The extract (100-400mg/kg, i.p.) significantly delayed (p<0.05) the onset of pentylenetetrazole-induced clonic seizures but only slightly prolonged the time of death of the mice. Although the findings in the present study do not provide conclusive evidence, it appears that the aqueous stem bark extract of Stereospermum kunthianum produces its antiseizure effect by enhancing GABAergic neurotransmission and/or action in the brain. The results indicate that the aqueous extract possesses anticonvulsant activity in rodents and therefore tend to suggest that the shrub may be used as a natural supplementary remedy in the management, control and/or treatment of childhood convulsions. It can be concluded that the aqueous stem bark extract possesses anticonvulsant activity and therefore lend pharmacological credence to the traditionally claimed use in the treatment of childhood convulsions.

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Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum

Cited by 81 publications

References 14 publications

Phytochemical and Antibacterial Properties of Leaf Extract of Stereospermum kunthianum (Bignoniaceae)

Phytochemical and Antibacterial Properties of Leaf Extract of Stereospermum kunthianum (Bignoniaceae)

Antidiarrhoeal Activity of Chromatographic Fractions of Stereospermum kunthianum Cham Sandrine Petit (Bignoniaceae) Stem Bark

Aqueous stem bark extract of <i>Stereospermum kunthianum </i> (cham, sandrine petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents.

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