Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell.

Tahir, Ahmed El; Satti, Gwiria M. H.; Khalid, Sami A.

doi:10.1016/s0378-8741(98)00129-9

Cited by 136 publications

(82 citation statements)

References 12 publications

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“…K. senegalensis stem bark solvent extracts significantly inhibited the growth of HCT-15, HT-29 and HCA-7 colorectal carcinoma cells. 6,14 This inhibition is comparable to the inhibition of the Caco-2 colorectal cells in our study. Furthermore, that study also examined the inhibitory mechanism and determined that the bark extracts had both antiproliferative and pro-apoptotic activities.…”

Section: Discussionsupporting

confidence: 89%

“…Whilst several studies verifying bioactivities associated with ethnobotanical usage exist, many of these reports have focussed on the bark, and to a lesser extent, the leaf. Bark extracts have been reported to have good anticancer 6,13,14 and anti-inflammatory properties 6 are good immunostimulants 11 and are insect deterrents. 8 K. senegalensis bark extracts have potential in the treatment of diabetes and have been reported to have anti-hyperglycemic activity comparable to glibenclamide.…”

Section: An Examination Of the Antimicrobial And Anticancer Propertiementioning

confidence: 99%

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An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

Rabadeaux¹,

Vallette²,

Sirdaarta³

et al. 2017

Phcog J

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Background: Khaya senegalensis (Desr.) A. Juss. is a common component of the pharmacopeia's of multiple African groupings which inhabit the areas in which it grows. Amongst these groups there is a myriad of medicinal uses in the treatment of a wide variety of bacterial, fungal and protozoal infections, as well as in the treatment of cancers. This study was undertaken to test K. senegalensis bark extracts for the ability to inhibit microbial and cancer cell growth, and thus to validate traditional African medicinal usage of this plant in treating a variety of diseases. Materials and Methods: K. senegalensis bark powder was extracted by both solvent maceration and subcritical fluid extraction (SFE). The extracts were tested for the ability to inhibit bacterial and G. duodenalis growth. Inhibition of Caco-2 and HeLa cancer cells was evaluated using MTS-based colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay and GC-MS headspace analysis was used to identify phytochemical components. Results: K. senegalensis bark extracts displayed strong inhibitory activity against bacterial triggers of several autoimmune inflammatory diseases. The growth inhibitory activity of the methanolic and subcritical extracts was particularly noteworthy against P. mirabilis (MIC values of 185 and 211µg/mL, respectively against the reference strains). These extracts were similarly potent growth inhibitors of K. pneumoniae and A. baylyi, and were moderate inhibitors (MIC >1000µg/mL) of P. aeruginosa and S. pyogenes growth. The methanolic and subcritical K. senegalensis extracts were also potent inhibitors of G. duodenalis (187 and 328µg/mL, respectively), as well as Caco-2 (268 and 470µg/mL, respectively) and HeLa carcinomas (155 and 174µg/mL, respectively). GC-MS analysis of the SFE extract revealed relative abundances of a variety of mono-and sesquiterpenoids. Furthermore, all K. senegalensis bark extracts were non-toxic in the Artemia franciscana toxicity assay, indicating their safety for therapeutic use. Conclusion: These studies validate traditional African therapeutic usage of K. senegalensis in the treatment of microbial infections, autoimmune inflammatory diseases and some cancers.

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Section: Discussionsupporting

confidence: 89%

Section: An Examination Of the Antimicrobial And Anticancer Propertiementioning

confidence: 99%

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

Rabadeaux¹,

Vallette²,

Sirdaarta³

et al. 2017

Phcog J

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“…emetica subsp. suberosa) was active (El Tahir et al, 1999;Traore-Keita et al, 2000;Prozesky et al, 2001). Our studies analysed for the first time the in vitro activity of P. laxiflora and C. sieberiana on trypanosomes, leishmania and mammalian cells.…”

Section: Discussionmentioning

confidence: 92%

In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants

Hoet

Opperdoes

Brun

et al. 2004

Journal of Ethnopharmacology

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The in vitro antitrypanosomal activity of methylene chloride, methanol and aqueous extracts of the leaves and twigs of five plant species traditionally used in Benin for the treatment of sleeping sickness were evaluated on Trypanosoma brucei brucei and their selectivity was analysed on Leishmania mexicana mexicana and J774 macrophage-like murine cells. The results showed that the four most active extracts had MIC values ≤19 g/ml (Hymenocardia acida twig and leaf, Strychnos spinosa leaf, Trichilia emetica leaf methylene chloride extracts).All these extracts had a lower activity on L. m. mexicana and J774 cells. Determination of the IC 50 values of the methylene chloride leaf extracts on two strains of trypanosomes (T. b. brucei and T. b. rhodesiense) and two mammalian cell lines (L6 and J774 cells) showed that all extracts possessed some antitrypanosomal activity with IC 50 's ranging from 1.5 to 39 g/ml. All were also toxic to the mammalian cells, but usually with higher IC 50 's. The only exception was the S. spinosa methylene chloride leaf extract which had no toxicity on J774 cells. Although tannins have been identified in most of the species studied, they could not be detected in the most active extracts, just as alkaloids. The presence of flavonoids and quinones may at least in part explain the observed activities of some of the active extracts.

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“…1841 species are commonly used in popular medicine due to the attributed anti-spasmodic, contraceptive, antiulcerogenic, diuretic, cicatrisation and analgesic properties (Ohsaki et al, 2004;Vilegas et al, 1995;Tahir et al, 1999;Queiroga et al, 2000). The antiulcerogenic activity of buffered aqueous extracts of Maytenus ilicifolia and Maytenus aquifolia has been confirmed in laboratory tests ( Souza-Formigori and Oliveira, 1991;Oliveira et al, 1991).…”

Section: Triterpenes Extraction Proceduresmentioning

confidence: 99%

Chemical variation of tannins and triterpenes in Brazilian populations of Maytenus ilicifolia Mart. Ex Reiss

et al. 2009

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Maytenus ilicifolia and Maytenus aquifolia species are widely used as a cicatrisation agent, an anti-spasmodic, contraceptive, antiulcerogenic, diuretic and analgesic. Considering the importance of these species in popular medicine, this work is focused on the determination of the chemical content of tannins and the triterpenes friedelan-3-one, friedelan-3-ol and friedelin in 15 native populations of Maytenus ilicifolia distributed in the south and mind-west regions of Brazil. Correlation of the concentration of these compounds with the environmental parameters such as average annual temperature, climate, vegetation, geomorphology, latitude and altitude was determined using Pearson's coefficient. Results showed that average annual temperature and climate have significant effect on tannin content at a 95% confidence level. The highest tannin concentration was found in Ponta Porã population, and for the triterpenes investigated, a significant correlation between their concentrations with the environmental variables studied was not verified.Keywords: Maytenus, chemical variability, supercritical extraction. Variabilidade química de taninos e triterpenos em diferentes populações naturais de Maytenus ilicifolia Mart. Ex Reiss ResumoAs espécies de Maytenus ilicifolia e Maytenus aquifolia são utilizadas como antiespasmódico, contraceptivo, antiulcerogênico, diurético, cicatrizante e analgésico. A ação antiulcerogênica dos extratos de Maytenus ilicifolia possuem relação com a presença de taninos e com os triterpenos friedelan-3-ona, friedelan-3-ol e friedelin. Este trabalho está focado na determinação do teor de taninos e dos triterpenos friedelan-3-ona, friedelan-3-ol e friedelin em 15 populações nativas de Maytenus ilicifolia distribuídas nas regiões Sul e Centro-Oeste do Brasil. A correlação entre a concentração destes compostos com variáveis ambientais, tais como temperatura média anual (TMA), clima segundo Koeppen, vegetação, geomorfologia, latitude e altitude foi determinada através do emprego da correlação de Pearson. Os resultados mostraram que as variáveis temperatura média anual e clima apresentaram influência significativa ao nível de confiança de 95% sobre a concentração de taninos. O maior teor de taninos foi encontrado na população de Ponta Porã, a qual possui uma temperatura média anual de 23 °C. Para os triterpenos estudados, friedelan-3-ona, friedelan-3-ol e friedelin, não foi evidenciada correlação significativa entre a concentração destes compostos com as variáveis ambientais estudadas.Palavras-chave: Maytenus, variabilidade química, extração em fluido supercrítico.

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Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell.

Cited by 136 publications

References 12 publications

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants

Chemical variation of tannins and triterpenes in Brazilian populations of Maytenus ilicifolia Mart. Ex Reiss

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