Antiplasmodial Alkaloids from the Bark of  Cryptocarya nigra (Lauraceae)

Nasrullah, Ayu Afiqah; Zahari, Azeana; Mohamad, Jamaludin; Awang, Khalijah

doi:10.3390/molecules18078009

Cited by 31 publications

(32 citation statements)

References 33 publications

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“…Analysis of the phytochemical constituents of LOE and fractions show that alkaloids, saponins, tannins and flavonoids abundant in the most active fraction, LOMF, may be largely responsible for the antiplasmodial effects of L. owariensis leaf. The antiplasmodial activity of various alkaloids (Saxena et al 2003;Oliveira et al 2009;Nasrullah et al 2013), saponins (Oketch-Rabah et al 1997;Traore et al 2000), tannins (Asres et al 2001) and flavonoids (Saxena et al 2003;Batista et al 2009;Zakaria et al 2012) have been reported. Identification of the antiplasmodial constituent(s) of L. owariensis leaf is ongoing.…”

Section: Discussionmentioning

confidence: 99%

Landolphia owariensisleaf extracts reduce parasitemia inPlasmodium berghei-infected mice

Ezike

Okonkwo

Akah

et al. 2016

Pharmaceutical Biology

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Context Landolphia owariensis P. Beauv. (Apocyanaceae) leaf is used in southeast Nigeria to treat malaria. Objective This study evaluated the antiplasmodial activity of L. owariensis leaf extract and fractions, also the phytoconstituents were standardized and analyzed. Methods The effects of daily, oral administrations of 200, 400 and 800 mg/kg of L. owariensis leaf extract (LOE), its hexane (LOHF), ethyl acetate (LOEF) and methanol (LOMF) fractions on early, established and residual infections in Plasmodium berghei-infected albino mice were evaluated in vivo. The extract and fractions were subjected to phytochemical analysis and HPLC fingerprinting, and the acute toxicity of LOE was evaluated.Results The extract and fractions elicited 29-86, 18-95 and 75-96% significant (p50.001) suppression of parasitemia in early, established and residual infections, respectively. The ED 50 values for suppressive activity of LOE, LOHF, LOEF and LOMF were 266.56, 514.93, 392.95 and 165.70 mg/kg, respectively. The post-day 30-survival index was 16.7-50, 16.7, 16.7-66.7 and 50-83.3% for LOE, LOHF, LOEF, and LOMF, respectively. Extract-treated mice significantly (p50.001) gained weight and had reduced mortality compared with negative control (untreated) mice. An oral LD 50 value 45000 mg/kg in mice was established for LOE. The LOMF showed the greatest antiplasmodial activity in all the models, suggesting that the antimalarial activity of the plant may be attributed to alkaloids, flavonoids, saponins and tannins present in the fraction. Conclusion Results demonstrate the antiplasmodial activity of L. owariensis leaf, and provide a pharmacological rationale for its ethnomedicinal use as an antimalarial agent. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Landolphia owariensisleaf extracts reduce parasitemia inPlasmodium berghei-infected mice

Ezike

Okonkwo

Akah

et al. 2016

Pharmaceutical Biology

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“…Possibly, the fusion of the two isoquinoline rings (in compound 26) enhances antiplasmodial activity. In another study, Nasrullah et al [34] e N,N-dimethyl groups of the ethylamine side chain (in compounds 33 and 34) are, perhaps, essential for antiplasmodial activity. Malebo et al [35] also isolated four pure alkaloids including palmatine (36) and mixtures of alkaloids from the leaves of Annickia kummeriae.…”

Section: Phenanthroindolizine Alkaloidsmentioning

confidence: 95%

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

105

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Malaria is one of the major health problems in developing countries. The disease kills a large number of people every year and also affects financial status of many countries. Resistance of the plasmodium parasite, the causative agent, to the existing drugs, including chloroquine, mefloquine, and artemisinin based combination therapy (ACT), is a serious global issue in malaria treatment and control. This warrants an urgent quest for novel compounds, particularly from natural sources such as medicinal plants. Alkaloids have over the years been recognized as important phytoconstituents with interesting biological properties. In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented. Several classes of alkaloids, including terpenoidal, indole, bisindole, quinolone, and isoquinoline alkaloids, were identified with a promising antimalarial activity. It is hoped that the reports of the review work will spur further research into the structural modification and/or development of the interesting compounds as novel antimalarial drugs.

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“…Plants of Lauraceae are rich sources of bioactive alkaloids [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The majority of alkaloids isolated from Beilschmiedia species possess aporphine skeletons ( 71 , Table 3 ) or benzylisoquinoline ( 72 ) skeletons.…”

Section: Chemical Constituentsmentioning

confidence: 99%

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

et al. 2015

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Plants of the Lauraceae family are widely used in traditional medicine and are sources of various classes of secondary metabolites. Two genera of this family, Beilschmiedia and Endiandra, have been the subject of numerous investigations over the past decades because of their application in traditional medicine. They are the only source of bioactive endiandric acid derivatives. Noteworthy is that their biosynthesis contains two consecutive non-enzymatic electrocyclic reactions. Several interesting biological activities for this specific class of secondary metabolites and other constituents of the two genera have been reported, including antimicrobial, enzymes inhibitory and cytotoxic properties. This review compiles information on the structures of the compounds described between January 1960 and March 2015, their biological activities and information on endiandric acid biosynthesis, with 104 references being cited.

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Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae)

Cited by 31 publications

References 33 publications

Landolphia owariensisleaf extracts reduce parasitemia inPlasmodium berghei-infected mice

Landolphia owariensisleaf extracts reduce parasitemia inPlasmodium berghei-infected mice

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

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