Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark of Erythrina senegalensis

Saidu, K; Onah, Johnson Ogoda; Orisadipe, A.; Olusola, Augustine O; Wambebe, Charles; Gamaniel, K.

doi:10.1016/s0378-8741(00)00188-4

Cited by 91 publications

(75 citation statements)

References 4 publications

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“…The species Erythrina glauca and Erythrina lysistemon have been reported to possess antiviral and antibacterial activity (1,4). Furthermore, analgesic and anti-inflammatory effects were observed for an aqueous extract of the stem bark of Erythrina senegalensis (5).…”

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confidence: 99%

Effect of acute treatment with a water-alcohol extract of Erythrina mulungu on anxiety-related responses in rats

Onusic

Nogueira

Pereira

et al. 2002

Braz J Med Biol Res

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We investigated the effect of acute oral treatment with a water-alcohol extract of the inflorescence of Erythrina mulungu (EM, LeguminosaePapilionaceae) (100, 200 and 400 mg/kg) on rats submitted to different anxiety models: the elevated T-maze (for inhibitory avoidance and escape measurements), the light/dark transition, and the cat odor test. These models were selected for their presumed capacity to demonstrate specific subtypes of anxiety disorders as recognized in clinical practice. Treatment with 200 mg/kg EM impaired avoidance latencies (avoidance 1 -200 mg/kg EM: 18 ± 7 s, control group: 40 ± 9 s; avoidance 2 -200 mg/kg EM: 15 ± 4 s, control group: 110.33 ± 38 s) in a way similar to the reference drug diazepam (avoidance 1: 3 ± 0.79 s; avoidance 2: 3 ± 0.76 s), without altering escape. Additionally, the same treatments increased the number of transitions (200 mg/kg EM: 6.33 ± 0.90, diazepam: 10 ± 1.54, control group: 2.78 ± 0.60) between the two compartments and the time spent in the lighted compartment in the light/dark transition model (200 mg/kg EM: 39 ± 7 s; diazepam: 61 ± 9 s; control group: 14 ± 4 s). The dose of 400 mg/kg EM also increased this last measurement (38 ± 8 s). These results were not due to motor alterations since no significant effects were detected in the number of crossings or rearings in the arena. Furthermore, neither EM nor diazepam altered the behavioral responses of rats to a cloth impregnated with cat odor. These observations suggest that EM exerts anxiolytic-like effects on a specific subset of defensive behaviors, particularly those that have been shown to be sensitive to low doses of benzodiazepines.

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confidence: 99%

Effect of acute treatment with a water-alcohol extract of Erythrina mulungu on anxiety-related responses in rats

Onusic

Nogueira

Pereira

et al. 2002

Braz J Med Biol Res

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“…& Dalz. afforded six further compounds (1)(2)(3)(4)(5)(6). The 1 H-and 13 C-NMR spectra of compound 1 showed resonances for 25 carbons and 28 protons.…”

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confidence: 99%

“…are used against several important diseases in their respective area of distribution. [3][4][5] Erythrina addisoniae Hutch. & Dalziel, which occurs in Ghana and other West-African states, is used to treat dysentery, hepatitis, rheumatic disorders and pain, as well as swellings and cancer.…”

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Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death

et al. 2015

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Extracts of Erythrina addisoniae are frequently used in the traditional medicine of Western Africa, but only insufficient information about active compounds is available. From the stem bark of Erythrina addisoniae, three new (1, 2, 4) and three known (3, 5, 6) flavanones were isolated: addisoniaflavanones I and II, containing either a 2´´,3´´-epoxyprenyl moiety (1) or a 2´´,3´´-dihydroxyprenyl moiety (2) were shown to be highly toxic (MTT-assay: EC 50 -values of 5.25 +/-13.5 and 8.5 +/-15.2 µM, respectively) against H4IIE hepatoma cells. The cytotoxic potential of the other isolated flavanones was weaker (range of EC 50 -values between 15 and >100 µM). Toxic effects of addisoniaflavanone I and II were detectable after 3 h (MTT assay). Both compounds induced an apoptotic cell death (caspase 3/7 activation, nuclear fragmentation) in the hepatoma cells and, at high concentrations, also necrosis (membrane disruption: ethidium bromide staining), Formation of DNA strand breaks was not detectable after incubation with these compounds (comet assay). In conclusion, the new prenylated flavanones addisoniaflavanones I and II may be of interest for pharmacological purposes (e.g. potential use as cytostatic drugs) due to their high cytotoxic and pro-apoptotic potential.

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“…Da mesma forma, estudo toxicológico para determinar a toxicidade aguda do extrato aquoso das folhas de E. velutina, indicou que a administração aguda é atóxica por via oral em ratos, uma vez que não foram observados mortalidade ou sintomas adversos após a administração da dose limite de 5 g kg -1 (Silva, 2008).…”

Section: Ensaios Fitoquímicos Folha Inflorescênciaunclassified

“…Classe dos flavonóides presentes nos extratos hidroalcóolicos das folhas e das inflorescências de E. mulungu. para a casca de E. senegalensis que f oi aproximadamente 450 mg kg -1 (Saidu et al, 2000) e para E. falcata, que apresentou dose intermediária entre 3,75 g kg -1 e 5,0 g kg -1 (Cerutti et al, 2000). Os resultados reforçam que metabólitos secundários apresentam-se de formas distintas nos diferentes órgãos vegetais, tanto em conteúdo como nas proporções disponíveis (Gobbo-Neto & Lopes, 2007), afetando dessa forma, a qualidade e segurança dos preparados fitoterápicos.…”

Section: Ensaios Fitoquímicos Folha Inflorescênciaunclassified

Estudo fitoquímico e análise mutagênica das folhas e inflorescências de Erythrina mulungu (Mart. ex Benth.) através do teste de micronúcleo em roedores

Bona

Batitucci

Andrade

et al. 2012

Rev. bras. plantas med.

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RESUMO:Este trabalho teve como objetivo investigar a composição química, estabelecer a dose letal média (DL 50 ) e av aliar os potenciais efeitos mutagênicos do extrato hidroalcoólico de folhas e inflorescências de Erythrina mulungu Mart. ex Benth por meio do teste de micronúcleo em medula óssea de camundongos. Os ensaios fitoquímicos foram realizados através de reações preliminares com mudança de coloração e/ou formação de precipitado; a DL 50 , por meio da administração intraperitoneal de três concentrações dos extratos, avaliando-se o número de óbitos após 48 horas e o teste de micronúcleo foi feito por meio do método do esfregaço, após exposição dos animais a cinco dias de tratamento. Os resultados fitoquímicos demonstraram presença de açúcares redutores, fenóis e taninos, proteínas e aminoácidos, flavonóides, alcalóides, depsídeos e depsidonas e derivados de cumarina em ambos os órgãos; saponinas espumídicas e esteróides e triterpenóides nas folhas e glicosídeos cardiotônicos e antraquinônicos e alcalóides nas inflorescências. Para a DL 50 a folha demonstrou-se atóxica e a inflorescência moderadamente tóxica. Para o teste de micronúcleo, os resultados indicaram ausência de citotoxicidade e genotoxicidade dosedependente para as folhas e independente da dose para as inflorescências. Assim, esses resultados sugerem que a planta, nas condições analisadas, possui potencial para induzir danos ao DNA. Palavras-chave:Erythrina mulungu, composição química, DL50, micronúcleo ABSTRACT: Phytochemical and mutagenic analysis of leaves and inflorescences of Erythrina mulungu (Mart. Ex Benth) through micronucleus test in rodents. This study aimed to investigate the chemical composition, to establish the mean lethal dose (LD 50 ) and to assess the potential mutagenic effects of hydroalcoholic extract of leaves and inflorescences of Erythrina mulungu Mart. ex Benth by using micronucleus test in bone marrow of mice. Phytochemical assays were carried out through preliminary reactions with color change and/or precipitate formation; the LD 50 was obtained by intraperitoneal administration of three concentrations of the extracts, assessing the number of deaths after 48 hours, and the micronucleus test was done by the smear method, after exposure of animals to five days of treatment. Phytochemical results showed the presence of reducing sugars, phenols and tannins, proteins and amino acids, flavonoids, alkaloids, depsides, depsidones and coumarin derivatives in both organs; foaming and steroidal saponins and triterpenes in the leaves and cardiotonic and anthraquinonic glycosides and alkaloids in the inflorescences. Considering the LD 50 , the leaf was atoxic and the inflorescence was moderately toxic. As regards the micronucleus test, results indicated absence of cytotoxicity while genotoxicity was dose-dependent for leaves and dose-independent for inflorescences. Thus, these results suggest that the plant, under the tested conditions, has the potential to induce damages to the DNA.

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Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark of Erythrina senegalensis

Cited by 91 publications

References 4 publications

Effect of acute treatment with a water-alcohol extract of Erythrina mulungu on anxiety-related responses in rats

Effect of acute treatment with a water-alcohol extract of Erythrina mulungu on anxiety-related responses in rats

Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death

Estudo fitoquímico e análise mutagênica das folhas e inflorescências de Erythrina mulungu (Mart. ex Benth.) através do teste de micronúcleo em roedores

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