Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: Takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae)

Houël, Emeline; Fleury, Marie; Odonne, Guillaume; Nardella, Flore; Bourdy, Geneviève; Vonthron-Sénécheau, Catherine; Villa, Pascal; Obrecht, Adeline; Éparvier, Véronique; Deharo, Eric; Stien, Didier

doi:10.1016/j.jep.2015.03.015

Cited by 20 publications

(15 citation statements)

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“…The reduction of parasite induced pro‐inflammatory cytokine production in ANC treatment group is because of the inhibition of parasitaemia in murine model malaria. There are several reports suggesting that excessive production of pro‐inflammatory cytokines in malaria pathogenesis is a secondary consequence because of parasite‐mediated immune stimulation (Good et al, ; Mohanty et al, ; Houel et al, ). Standard anti‐malarial drugs (Chloroquine and Artemisinin derivatives) have shown anti‐parasite effect and limiting the potentially deleterious host inflammatory response during severe malaria pathogenesis (Agarwal et al, ; Guiguemde et al, ).…”

Section: Discussionmentioning

confidence: 99%

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

et al. 2016

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Diarylheptanoids from Alnus nepalensis leaves have been reported for promising activity against filariasis, a mosquito-borne disease, and this has prompted us to investigate its anti-malarial and safety profile using in-vitro and in-vivo bioassays. A. nepalensis leaf extracts were tested in-vitro against chloroquine-sensitive Plasmodium falciparum NF54 by measuring the parasite specific lactate dehydrogenase activity. Among all, the chloroform extract (ANC) has shown promising anti-plasmodial activity (IC50 8.06 ± 0.26 µg/mL). HPLC analysis of ANC showed the presence of diarylheptanoids. Efficacy and safety of ANC were further validated in in-vivo system using Plasmodium berghei-induced malaria model and acute oral toxicity in mice. Malaria was induced by intra-peritoneal injection of P. berghei infected red blood cells to the female Balb/c mice. ANC was administered orally at doses of 100 and 300 mg/kg/day following Peter's 4 day suppression test. Oral administration of ANC showed significant reduction of parasitaemia and increase in mean survival time. It also attributed to inhibition of the parasite induced pro-inflammatory cytokines as well as afford to significant increase in the blood glucose and haemoglobin level when compared with vehicle-treated infected mice. In-vivo safety evaluation study revealed that ANC is non-toxic at higher concentration. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

et al. 2016

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“…The bioassays were performed as reported previously (Houël et al, 2015). Briefly, RAW 264.7 cells (ATCC TIB-71) were stimulated with lipopolysaccharide (LPS, Sigma, 5 µg/mL) and treated with 2 concentrations of ethyl acetate fraction (D) or pure guaijaverin (4) (50 µg/mL or 10 µg/mL,) diluted in DMSO.…”

Section: Pldh Assaymentioning

confidence: 99%

“…2.7.2. Peripheral blood mononuclear cells (PBMCs) isolation and culture PBMCs were prepared from the peripheral blood of healthy donors (Etablissement Français du Sang) as reported previously (Houël et al, 2015). Isolated PBMCs were stimulated with 5 µg/mL LPS (Sigma).…”

Section: Pldh Assaymentioning

confidence: 99%

“…In Houël et al (2015), we highlighted P. acutangulum decoction's antimalarial properties and demonstrated in vitro a significant dose dependent effect of the remedy on selected cytokines secretion and NO production, without cytotoxicity on L6 cell line, RAW cells and PBMC. This species is however poorly described on a phytochemical point of view, aside from the isolation of flavonols and α,β-insaturated ketones (Miles et al, 1991;Rivero-Maldonado et al, 2013), the latter family of compounds being interestingly known to exhibit antimalarial activity (Singh et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…In vitro antiplasmodial activity 2.6.1. [ 3 H]-hypoxanthine assay [ 3 H]-hypoxanthine assays were performed on P. falciparum FcB1 strain (chloroquine resistant) and NF54 strain (chloroquine sensitive) according to a procedure adapted from Le Bras and Deloron (1983) and Benoit et al (1996) as reported previously (Houël et al, 2015).…”

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Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians

Houël

Nardella

Jullian

et al. 2016

Journal of Ethnopharmacology

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Psidium L. genus: A review on its chemical characterization, preclinical and clinical studies

Beltrame

Klein‐Júnior

Schwanz

et al. 2021

Phytotherapy Research

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The Myrtaceae family is considered one of the largest known botanical families and the genus Psidium is among the most economically interesting. Psidium genus comprises approximately 112 species, and it has been extensively studied, mainly because of Psidium guavaja species. Phytochemical investigations confirmed the presence of phenolics as the main compounds, as well as the essential oils, which were also widely investigated. Pharmacological studies report analgesic, anthelminthic, acaricidal, antihiperglicemic, among other biological activities for different species. The present review covers the relevant literature until 2019 and outlines the current data on chemical composition, preclinical and clinical studies on Psidium species, as well as the main possible mechanisms of action responsible for the described activities. Therefore, it can provide a reference for pharmaceutical research and clinical application of this genus.

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Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: Takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae)

Cited by 20 publications

References 35 publications

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians

Psidium L. genus: A review on its chemical characterization, preclinical and clinical studies

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