Antiplasmodial and antileishmanial inhibitory activity of triterpenes and steroidal alkaloid from the leaves of Funtumia elastica (Preuss) Stapf (Apocynaceae)

Ma'mag, Larissa Kom; Zintchem, Auguste Abouem A; Théodora, Kopa Kowa; Atchadé, Alex de Théodore; Lauve, Tchokouaha Yamthe; Frédérich, Michel; Bikobo, Dominique Serge Ngono; Pegnyemb, Dieudonné Emmanuel

doi:10.1016/j.fitote.2021.104869

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…e other extracts, (hexane and dichloromethane/methanol) showed low in vitro antimalarial activity against W2 strain Evidence-Based Complementary and Alternative Medicine 3 [31]. Recently, Ma'mag et al and Bitombo et al highlighted the antiplasmodial activity of two Apocynaceae, Funtunia elastica [30], and Tabernaemontana penduliflora [40]. Methanol extract of Funtunia elastica exhibited a very high antiplasmodial activity against both Dd2 and 3D7 P. falciparum strains (IC50 < 5 µg/ml).…”

Section: Apocynaceae Ndjakou Lenta Et Almentioning

confidence: 99%

The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis

Tepa

Ambassa

Ayong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Malaria is a real public health problem. It is the leading cause of morbidity and mortality in the world. Research in herbal medicine has so far shown that the use of plants against malaria is not to be neglected. This review aims to highlight the antiplasmodial potential of Cameroonian plants. In order to achieve this objective, we conducted a bibliographic search in April 2022 using the PubMed search engine. This research included both the published and unpublished studies. A narrative approach was used to describe the antiplasmodial potential of the various species of plants investigated. Quantitative data were analyzed using R studio 4.1.1 software and random effects model was used to estimate the effect size. The research of the antiplasmodial activity of Cameroonian plants dates back to 2000. This area of research has since provided extensive data to indicate the antiplasmodial potential of several plants, most of which originate from the central region. Despite the heterogeneity observed between the different plant families studied in Cameroon for their in vitro antiplasmodial effect, there is strong evidence that 17 active compounds from these plants would be ideal candidates for the synthesis of new antimalarial drugs. The Dacryodes edulis species could be considered as the best natural alternative in the treatment of uncomplicated malaria according to its properties. It is clear that the traditional Cameroonian pharmacopoeia has many species that contain compounds with antiplasmodial activity. More studies need to be conducted to explore the multitude of unexplored plants that are used in traditional medicine. These studies should take into account the nature of the cell model used for cytotoxicity assessment.

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Section: Apocynaceae Ndjakou Lenta Et Almentioning

confidence: 99%

The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis

Tepa

Ambassa

Ayong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Decoction of the leaf of Funtumia elastica has been found to specifically inhibit the growth of many moulds, including Aspergillus sp, Penicillium sp, Candida sp, as well as the fungi that cause ring worm [9]. Its Antiplasmodial and antileishmanial inhibitory activity has as well been reported [7]. It is also reportedly used in the treatment of wounds [10].…”

Section: Introductionmentioning

confidence: 99%

“…Many species of the Apocynaceae family are found in the tropical forest, but some grow on temperate regions as perennial herbs. Preliminary phytochemical screening has revealed that F. elastica bark contains hydrolysable tannins, sapogenetic glycosides, steroids, and saponins [7], while the leaves contain hydrolysable tannins, flavonoids, starch, and alkaloids with the tannin content of the leaves and stem bark being 2.4% and 1.3% w/w (relative to the dried material), respectively [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antibacterial Activity and Toxicity Properties of Funtumia elastica (Preuss) Stapf. (TSN 30176), Used in Traditional Medicine in Nigeria

Iloka,

Igbokwe,

Ike

et al. 2023

JOCAMR

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Background: The urgent need for new and novel antibacterial chemotherapy to combat the worrisome emergence of antimicrobial resistance necessitated the exploration of medicinal plants such as Funtumia elastica. This study was designed to evaluate the antibacterial activity, acute and sub-acute toxicity studies of Funtumia elastica which is used in the ethnomedical treatment of infections. Methods: The leaves and stem bark of F. elastica were collected, pulverized, extracted using soxhlet extractor and evaluated phytochemically. Antibacterial activities and Minimum Inhibitory Concentrations (MIC) of the crude extracts were investigated on clinical isolates using agar well diffusion. Bioactive fractions of the dichloromethane extract were obtained through column chromatography and thin layer chromatography. Acute and subacute toxicity studies were evaluated on the dichloromethane extract (DCM) using female Swiss albino mice. Results: The leaves contain tannins, flavonoids, alkaloids, steroids, saponins, and glycosides while the stem contains tannins and steroids. The hexane extracts lack activities while DCM and ethylacetate extracts of F. elastica were found to have some degree of activities on tested clinical isolates. Bioactivity guided fractionation of the DCM extract yielded only fraction 2 been active on the clinical isolates at 3.5625mg/mL. There were no signs of acute toxicity at the maximum dose of 5000mg/kg body weight. Biochemical parameters showed no significant changes in the liver enzymes. This infers that the extract might not have any negative impact on the liver with regards to metabolism. Conclusion: The moderate antibacterial activities of Funtumia elastica extracts justified its ethnomedicinal uses and potential to furnish new antimicrobials.

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Medicinally important natural bioactive compounds for leishmaniasis treatment: efficient alternate of toxic drugs

Iqbal¹,

Reeta²,

Ahluwalia³

et al. 2023

Studies in Natural Product Chemistry

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Antiplasmodial and antileishmanial inhibitory activity of triterpenes and steroidal alkaloid from the leaves of Funtumia elastica (Preuss) Stapf (Apocynaceae)

Cited by 8 publications

References 38 publications

The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis

The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis

Evaluation of the Antibacterial Activity and Toxicity Properties of Funtumia elastica (Preuss) Stapf. (TSN 30176), Used in Traditional Medicine in Nigeria

Medicinally important natural bioactive compounds for leishmaniasis treatment: efficient alternate of toxic drugs

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