Antiplasmodial potential of traditional phytotherapy of some remedies used in treatment of malaria in Meru–Tharaka Nithi County of Kenya

Muthaura, C.N.; Keriko, Joseph M.; Mutai, Charles; Yenesew, Abiy; Gathirwa, Jeremiah; Irungu, Beatrice; Nyangacha, Ruth; Mungai, G.M.; Derese, Solomon

doi:10.1016/j.jep.2015.09.017

Cited by 58 publications

(43 citation statements)

References 42 publications

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“…Supporting evidence for this assertion come from the ethnobotanical claims as well as the in vitro antimalarial studies of H. forskalei . 14 , 18 , 19…”

Section: Discussionmentioning

confidence: 99%

“… 16 , 17 Furthermore, different in vitro studies also reported that the methanolic extracts of H. forskalei possessed antiplasmodial activity against P. falciparum with an IC50 of 5.13–8.8 µg/mL. 14 , 18 , 19 Besides, other species of the genus Hypoestes were also reported to have promising antimalarial activity in different in vitro studies. 16 , 20 This study, therefore, was initiated to investigate the antimalarial activity of the plant in a rodent model of malaria based on the strong supporting evidence from the in vitro anti-plasmodial activity together with ethnobotanical claims of H. forskalei .…”

Section: Introductionmentioning

confidence: 99%

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Chemo Suppressive and Curative Potential of Hypoestes forskalei Against Plasmodium berghei: Evidence for in vivo Antimalarial Activity

Misganaw

Amare

Mengistu

2020

JEP

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Background The emergence of drug resistance together with the global burden of malaria triggers the necessity for the searching of new antimalarial agents. This study, therefore, was initiated to investigate the in vivo antimalarial activity of Hypoestes forskalei in mice based on the strong supported evidence from the ethnobotanical claims and the in vitro anti-plasmodial activity of the plant. Methods The 4-day suppressive (crude extract and fractions) and the Rane’s (n-butanol fraction) tests were used to evaluate the antimalarial activity of the plant. A cold maceration technique with 80% methanol was used for the crude extraction of the plant. The crude extract was then fractionated using solvents of different polarity (chloroform, n-butanol, and water). Results All the test doses of the crude extract as well as the fractions reduced parasitemia and prolonged mean survival time significantly ( P <0.001) as compared to their negative control groups. Maximum parasitemia suppression effect (56%) was observed at the highest dose (600 mg/kg) of the crude extract during the 4-day suppressive test. Likewise, the n-butanol, chloroform, and aqueous fractions showed a percentage suppression of about 50, 38, and 19, respectively, at the dose of 600 mg/kg. Therefore, the n-butanol fraction showed the highest parasitemia suppression followed by the chloroform fraction and then the aqueous fraction. Moreover, the n-butanol fraction showed a significant curative effect ( P <0.001) in Rane’s test with a percentage suppression of about 49 at a dose of 600 mg/kg. Conclusion The study has revealed that the plant has a promising antimalarial activity, the activity being more in the crude extract than the fractions. The highest antimalarial activity of the n-butanol fraction suggests that non-polar and medium polar principles could be responsible for the observed activity.

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“…Supporting evidence for this assertion come from the ethnobotanical claims as well as the in vitro antimalarial studies of H. forskalei . 14 , 18 , 19…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemo Suppressive and Curative Potential of Hypoestes forskalei Against Plasmodium berghei: Evidence for in vivo Antimalarial Activity

Misganaw

Amare

Mengistu

2020

JEP

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“…Extracts from different parts of the plant have been reported previously to have antioxidant [11], antimicrobial [11–13] anti-diarrheal [14] molluscicidal [15] antiplasmodial [16] and anti-ulcerogenic effects [17]. There have also been reports on the anti-nociceptive effects of various parts of plants in the Ziziphus genus including Zizyphus spina-christi [18], Zizyphus oxyphylla [19] and Ziziphus mucronata [20] in animal models.…”

Section: Introductionmentioning

confidence: 99%

Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models

Boakye‐Gyasi

Henneh

Abotsi

et al. 2017

BMC Complement Altern Med

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BackgroundDespite substantial advances in pain research and treatment, millions of people continue to suffer from pain and this has been attributed mainly to the unavailability of effective and safer analgesics. The use of plants as medicines is still widespread and plants constitute a large source of novel phytocompounds that might become leads for the discovery of newer, effective and safer alternatives. Various parts of Ziziphus abyssinica have been used in folk medicine in several African countries as painkillers. However, there is no report on the possible anti-nociceptive effects of this plant especially the leaves, hence the need for this current study.MethodsThe possible anti-nociceptive activity of hydro-ethanolic leaf extract of Ziziphus abyssinica (EthE) was assessed in rodents using chemical (acetic acid, formalin and glutamate), thermal (tail-immersion test) and mechanical/inflammatory (carrageenan) models of nociception.ResultsEthE (30-300 mg/kg, p.o.) dose-dependently and significantly inhibited chemical-induced nociception with a maximum inhibition of 86.29 ± 2.27%, 76.34 ± 5.67%, 84.97 ± 5.35%, and 82.81 ± 5.97% respectively for acetic acid, formalin (phase 1), formalin (phase 2) and glutamate tests at its highest dose. EthE also dose-dependently and significantly increased reaction times in both tail-immersion and carrageenan-induced hypernociceptive tests. The activities of the extract in the various models were comparable with the effect of morphine hydrochloride and diclofenac sodium used as standard analgesic drugs.ConclusionOral administration of hydro-ethanolic leaf extract of Ziziphus abyssinica ameliorates nocifensive behaviours associated with chemical-, thermal- and mechanical/inflammatory - induced nociceptive pain.

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“…Desbois and Smith [ 71 ] argued that the antimicrobial properties of fatty acids are based on their ability to disturb and distort the oxidative phosphorylation process and the electron transport chain process, thereby disturbing the cellular energy production, leading to reduction of enzymatic activity, reduced nutrient uptake, and production of toxic peroxidation. The phytochemicals detected in various parts of V. madagascariensis may be used to justify some of the medicinal uses of this species recorded in Table 4 and also documented antibacterial [ 13 , 60 , 72 ], anticonvulsant [ 60 ], antidiabetic [ 13 , 73 ], antifungal [ 60 , 74 ], anti-inﬂammatory [ 60 ], antioxidant [ 13 , 17 ], cytotoxicity [ 17 ], antimalarial, and antiplasmodial [ 55 , 56 ] activities.…”

Section: Phytochemistry and Pharmacological Properties Of mentioning

confidence: 99%

Vangueria madagascariensisFruit Tree: Nutritional, Phytochemical, Pharmacological, and Primary Health Care Applications as Herbal Medicine

Maroyi

2018

Scientifica

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Vangueria madagascariensis J. F. Gmel. is a plant species regarded as an important fruit tree and medicinal plant in sub-Saharan Africa. This study critically reviewed the nutritional value, phytochemistry, medicinal uses, and pharmacological properties of V. madagascariensis. Relevant information on food and medicinal uses of the species was collected from electronic databases such as ISI Web of Knowledge, ProQuest, ScienceDirect, OATD, Scopus, OpenThesis, PubMed, and Google Scholar, and preelectronic literatures were obtained from the university library covering the period 1966 to 2018. Literature studies revealed that V. madagascariensis has been integrated into farming systems as a fruit tree to support income and nutritional security of households in the region. Vangueria madagascariensis is used as a herbal medicine against diabetes, gastrointestinal problems, malaria, pain, parasitic worms, and skin diseases. Phytochemical compounds identified from the species include alcohols, aldehydes, esters, furanoids, ketones, and terpenoids. Pharmacological studies revealed that V. madagascariensis extracts have antibacterial, anticonvulsant, antidiabetic, antifungal, anti-inﬂammatory, antioxidant, cytotoxicity, antimalarial, and antiplasmodial properties. Vangueria madagascariensis should be subjected to detailed nutritional, pharmacological, and toxicological evaluations aimed at correlating the traditional uses of the species and the scientific evidence as well as establishing the efficacy, clinical relevance, safety, and mechanisms of action of the plant extracts and compounds.

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Antiplasmodial potential of traditional phytotherapy of some remedies used in treatment of malaria in Meru–Tharaka Nithi County of Kenya

Cited by 58 publications

References 42 publications

<p>Chemo Suppressive and Curative Potential of <em>Hypoestes forskalei</em> Against <em>Plasmodium berghei</em>: Evidence for in vivo Antimalarial Activity</p>

<p>Chemo Suppressive and Curative Potential of <em>Hypoestes forskalei</em> Against <em>Plasmodium berghei</em>: Evidence for in vivo Antimalarial Activity</p>

Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models

Vangueria madagascariensisFruit Tree: Nutritional, Phytochemical, Pharmacological, and Primary Health Care Applications as Herbal Medicine

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