Antiplatelet and antithrombotic effects of cordycepin-enriched WIB-801CE from Cordyceps militaris ex vivo, in vivo, and in vitro

Kwon, Hyuk-Woo; Shin, Jung-Hae; Lim, Deok Hwi; Ok, Woo Jeong; Nam, Gi Suk; Kim, Min Ji; Kwon, Ho-Kyun; Noh, Jun-Hee; Je-Young, Lee; Kim, Hyun-Hong; Kim, Jong-Lae; Park, Hwa-Jin

doi:10.1186/s12906-016-1463-8

Cited by 17 publications

(6 citation statements)

References 80 publications

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“…WIB-801CE was prepared and analyzed by Whanin Pharmaceutical Corporation (Suwon, Korea) as described previously (Kwon et al, 2016). A voucher specimen (WCM06) of C. militaris has been depos-…”

Section: Preparation Of Wib-801cementioning

confidence: 99%

“…Importantly, the amount of codycepin containing WIB‐801CE (69.30 ± 0.20 mg/g, about 6.93%) was reported to be much higher than that of whole fruiting body myelia of C . militaris (about 0.16%; Kwon, Shin, Lim, et al, ). In addition, cordycepin‐enriched WIB‐801C attenuates blood‐spinal cord barrier disruption followed blood cell infiltration by inhibiting metalloprotease‐9 expression and activity, thereby ameliorates apoptotic cell death, and improves functional recovery after spinal cord injury (J. Y. Lee, Choi, Baik, et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Immunostimulatory effects of cordycepin‐enriched WIB‐801CE from Cordyceps militaris in splenocytes and cyclophosphamide‐induced immunosuppressed mice

Shin

Chung

Lee

et al. 2017

Phytotherapy Research

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The medicinal mushroom Cordyceps militaris has been reported to possess anticancer and immunomodulatory effects. We investigated the immunostimulatory effects of culture supernatant of C. militaris (WIB-801CE) by examining its in vitro enhancing effects on cell proliferation and cytokine releases in splenocytes and its in vivo effects on cyclophosphamide-induced immunosuppressed mice. WIB-801CE enhanced normal and methotrexate-induced cell proliferation.WIB-801CE significantly ameliorated interleukin (IL)-2, interferon-γ, and tumor necrosis factor-α secretion in methotrexate-induced splenocytes. Oral administration of WIB-801CE effectively increased the cyclophosphamide-suppressed splenocyte proliferation and natural killer cytotoxic activity. WIB-801CE effectively recovered cyclophosphamide-induced decreases in IL-2, interferon-γ, tumor necrosis factor-α, and IL-10 level. The collective data implicate WIB-801CE as a therapeutic candidate in ameliorating the immunosuppression through immunostimulatory properties.

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Section: Preparation Of Wib-801cementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunostimulatory effects of cordycepin‐enriched WIB‐801CE from Cordyceps militaris in splenocytes and cyclophosphamide‐induced immunosuppressed mice

Shin

Chung

Lee

et al. 2017

Phytotherapy Research

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“…Cordyceps is relatively safe but may cause allergies, nausea, and stomach aches in some cases. Certain medications, such as antidiabetic, antithrombotic, and anticancer drugs [ 31 , 231 , 232 ], may interact with Cordyceps; hence, it is advised to consult a doctor before consuming them. The most prominent concern is the accumulation of heavy metals, especially arsenic, in naturally growing mushrooms in contaminated soils.…”

Section: Safety and Toxicitymentioning

confidence: 99%

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Sharma,

2023

Nutrients

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Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma. Both these conditions share common pathophysiological features, like oxidative stress, neuroinflammation, and glutamatergic excitotoxicity. Cordyceps bioactives (adenosine, N6-(2-hydroxyethyl)-adenosine, ergosta-7, 9 (11), 22-trien-3β-ol, active peptides, and polysaccharides) exert potential antioxidant, anti-inflammatory, and anti-apoptotic activities and display beneficial effects in the management and/or treatment of neurodegenerative disorders in vitro and in vivo. Although a considerable list of compounds is available from Cordyceps, only a few have been evaluated for their neuroprotective potential and still lack information for clinical trials. In this review, the neuroprotective mechanisms and safety profile of Cordyceps extracts/bioactives have been discussed, which might be helpful in the identification of novel potential therapeutic entities in the future.

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“…Note: COR can also inhibit excitatory synaptic transmission [18] and have neuroprotective effects [19]. ER-COR has antiplatelet effects [20]. The [α-32P]-COR-TP is used for 3′-end radiolabeled RNA fragments [21].…”

Section: Figurementioning

confidence: 99%

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi

Qin

Yang

et al. 2019

Molecules

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Cordycepin (3′-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc. The investigation of the medicinal drug actions supports the discovery of novel targets and the development of new drugs to enhance the therapeutic potency and reduce toxicity. Cordycepin may be of great value owing to its medicinal potential as an external drug, such as in cosmeceutical, traumatic, antalgic and muscle strain applications. In addition, the biological application of cordycepin, for example, as a ligand, has been used to uncover molecular structures. Notably, studies that investigated the metabolic mechanisms of cordycepin-producing fungi have yielded significant information related to the biosynthesis of high levels of cordycepin. Here, we summarized the medicinal targets, biological applications, cytotoxicity, delivery carriers, stability, and pros/cons of cordycepin in clinical applications, as well as described the metabolic mechanisms of cordycepin in cordycepin-producing fungi. We posit that new approaches, including single-cell analysis, have the potential to enhance medicinal potency and unravel all facets of metabolic mechanisms of cordycepin in Cordyceps militaris.

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Antiplatelet and antithrombotic effects of cordycepin-enriched WIB-801CE from Cordyceps militaris ex vivo, in vivo, and in vitro

Cited by 17 publications

References 80 publications

Immunostimulatory effects of cordycepin‐enriched WIB‐801CE from Cordyceps militaris in splenocytes and cyclophosphamide‐induced immunosuppressed mice

Immunostimulatory effects of cordycepin‐enriched WIB‐801CE from Cordyceps militaris in splenocytes and cyclophosphamide‐induced immunosuppressed mice

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi

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