Antipoliovirus Activity of the Organic Extract of<i>Eupatorium buniifolium</i>: Isolation of Euparin as an Active Compound

Jaime, María Florencia Visintini; Campos, Rodolfo Héctor; Martino, Virginia; Cavallaro, Lorenzo; Muschietti, Liliana

doi:10.1155/2013/402364

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Antibacterial and antiviral activity [ 28 , 29 ] and protective effect on human lymphocytes against chromosomal damage [ 30 ] have been reported for jaceidin. Euparin has shown antipoliovirus activity [ 31 ] and cytotoxic activity against liver carcinoma cells [ 32 ]. This is the first time that the activity against T. cruzi and L. infantum of these compounds has been reported.…”

Section: Resultsmentioning

confidence: 99%

Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

Elso

Clavin

Hernández

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.

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Section: Resultsmentioning

confidence: 99%

Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

Elso

Clavin

Hernández

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Euparin is an anti-oxidant benzofuran that has been isolated from several species of Asteraceae, and it was the only phenolic compound from the series that showed activity against DENV-2 with selectivity of action. This natural compound has been evaluated for its activity against poliovirus, demonstrating an inhibition in the early stages of the poliovirus replication cycle, from virus adsorption to cells up to the first twenty minutes after infection, probably affecting the penetration and/or the uncoating process [ 25 ]. Moreover, this benzofuran exhibited activity against other RNA viruses such as respiratory syncytial virus (RSV) and pseudorabies virus strain RC/79 [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties

Borgo,

Wagner,

Laurella

et al. 2024

Molecules

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Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared from six Asteraceae species, including Acmella bellidioides, Campuloclinium macrocephalum, Grindelia pulchella, Grindelia chiloensis, Helenium radiatum, and Viguiera tuberosa, along with pure phytochemicals isolated from Asteraceae: mikanolide (1), eupatoriopicrin (2), eupahakonenin B (3), minimolide (4), estafietin (5), 2-oxo-8-deoxyligustrin (6), santhemoidin C (7), euparin (8), jaceidin (9), nepetin (10), jaceosidin (11), eryodictiol (12), eupatorin (13), and 5-demethylsinensetin (14). Results showed that the dichloromethane extracts of C. macrocephalum and H. radiatum and the methanolic extracts prepared from C. macrocephalum and G. pulchella were highly active and selective against DENV-2, affording EC50 values of 0.11, 0.15, 1.80, and 3.85 µg/mL, respectively, and SIs of 171.0, 18.8, >17.36, and 64.9, respectively. From the pool of phytochemicals tested, compounds 6, 7, and 8 stand out as the most active (EC50 = 3.7, 3.1, and 6.8 µM, respectively; SI = 5.9, 6.7, and >73.4, respectively). These results demonstrate that Asteraceae species and their chemical constituents represent valuable sources of new antiviral molecules.

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“…Linolenic acid compounds were found in the Syzygium paniculatum in the myrtaceae family with levels of (4.85%) and had antioxidant activity (Okoh et al 2019). Euparin compounds also exhibit antioxidant and antifungal activities (Jaime et al 2013). Aeruginosine compounds derived from cyanobacteria also have anti-inflammatory activity (Kapuścik et al 2013), benzofuran compounds have antioxidant activity (Miao et al 2019), and benzofuran was also found in Syzygium cumini L. (Ary et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Quercetin-Containing Extract from Clove Syzygium aromaticum L. Endophytic Bacteria, Fictibacillus phosphorivorans P1U2, Exhibits Antimutagenic Activity in Yeast Saccharomyces cerevisiae

Fany Ashafani,

Astuti,

Listiyowati

et al. 2023

HAYATI J Biosci

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Metabolites from clove (Syzygium aromaticum L.) have been extensively studied for various pharmacological uses, including quercetin. Endophytic bacteria isolated from plant tissues can produce similar secondary metabolites as their host plants. However, little is known about the antioxidant activity of the endophytic bacterial extract from clove leaves. Amongst the potential bacterial groups, the genera of Bacillus have been widely studied as a source of antioxidants. Thus, this study, we examined the potential antioxidant properties of Bacillus sp., isolated from clove leaves. We have successfully isolated ten endophytic bacteria, of which only one isolate (P1U2) was found non-pathogenic based on a hemolytic assay. Based on the 16S rRNA sequence, P1U2 shared the highest similarity to Fictibacillus phosphorivorans. The extract of extracellular metabolites of P1U2 contains quercetin compounds, based on LC-MS analysis. The results of the antioxidant activity test using the DPPH assay showed that the P1U2 extract had an IC50 value of 161 mg/ml. The supplementation of the extract on culture media reduced the ability of S. cerevisiae to decolorize mutagen malachite green and increased cell viability. Furthermore, the addition of 161 ppm extract was able to counteract UV mutagens effects of UV exposure and toxicity of malachite green, significantly increasing the growth of S. cerevisiae. Suggesting the bioactivity of the extract in combating mutagens. To the best of our knowledge, this is the first study to report a quercetin-rich extract derived from endophytic bacteria, F. phosphorivorans. Thus, further study is required to optimize the synthesis of quercetin from isolate P1U2.

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Antipoliovirus Activity of the Organic Extract ofEupatorium buniifolium: Isolation of Euparin as an Active Compound

Cited by 8 publications

References 25 publications

Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties

Quercetin-Containing Extract from Clove Syzygium aromaticum L. Endophytic Bacteria, Fictibacillus phosphorivorans P1U2, Exhibits Antimutagenic Activity in Yeast Saccharomyces cerevisiae

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