Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia

Balan, Kannan V.; Prince, Jeffrey S.; Han, Zhiyong; Dimas, Konstantinos; Cladaras, M H; Wyche, James H.; Sitaras, Nikolaos M.; Pantazis, Panayotis

doi:10.1016/j.phymed.2006.03.009

Cited by 137 publications

(105 citation statements)

References 33 publications

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“…lentiscus has also been traditionally regarded as an anticancer agent , especially on tumors of breast, liver, stomach, spleen, and uterus. These traditional beliefs are in line with recent studies demonstrating that CMG induces apoptosis (Balan et al 2005 ) and possesses antiproliferative activity (Balan et al, 2007 ) in colon cancer cells. As it was suggested by these researchers, CMG might be developed into a chemotherapeutic agent for the treatment of human colon and other cancers.…”

Section: Health Effects Antioxidant and Antimicrobial Propertiessupporting

confidence: 81%

Chios Mastic Gum and Its Food Applications

Paraskevopoulou

Kiosseoglou

2016

Functional Properties of Traditional Foods

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Section: Health Effects Antioxidant and Antimicrobial Propertiessupporting

confidence: 81%

Chios Mastic Gum and Its Food Applications

Paraskevopoulou

Kiosseoglou

2016

Functional Properties of Traditional Foods

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“…eczema, throat infections, diarrhea, renal stones, jaundice, asthma and gastric ulcer [1]. Mastic oil, the essential oil of mastic gum, a natural resin obtained from Pistacia lentiscus has a wide -range of therapeutic effects: anti-inflammatory, antibacterial, antifungal, antiviral, anticancer, and hypolipidemic activities [2,3,4,5,6,7,8,9,10,11,12,13]. Pistacia lentiscus is also effective in the treatment of functional dyspepsia and gastric ulcer [14,15,16] as well as in the healing of burns [17].…”

Section: Introductionmentioning

confidence: 99%

Short-Term Effects of Oral Administration of <b><i>Pistacia Lentiscus</i></b> Oil on Tissue-Specific Toxicity and Drug Metabolizing Enzymes in Mice

Attoub

Karam²,

Arafat³

et al. 2014

Cell Physiol Biochem

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Background: Pistacia lentiscus (Anacardiaceae) is a flowering plant traditionally used in the treatment of various skin, respiratory, and gastrointestinal disorders. The aim of this study was to assess whether Pistacia lentiscus oil has any short term toxic effects in vivo and in vitro. Methods: Pistacia lentiscus oil (100µl) was administered orally into mice for 5 days. Results: Measurements of body weight did not show any weight loss. Serum concentration of LDH did not show any significant statistical difference when compared to control mice. Similarly, blood, kidney or liver function tests showed no toxicity with Pistacia lentiscus oil when compared to the control group. Examination of gastrointestinal tissues sections revealed similar structural features with no difference in cell proliferation. In this context, pharmacological dilutions of Pistacia lentiscus oil (10^-6 - 10^-3) did not affect the viability (cell death and proliferation) of mouse gastric stem cells, human colorectal cancer cells HT29, human hepatoma cells HepG2. However, it appears that at the dose and time point studied, Pistacia lentiscus oil treatment has targeted various cytochrome P450s and has specifically inhibited the activities and the expression of CYP2E1, CYP3A4, CYP1A1 and CYP1A2 differentially in different tissues. Our results also demonstrate that there is no appreciable effect of Pistacia lentiscus oil on the GSH-dependent redox homoeostasis and detoxification mechanism in the tissues. Conclusion: These data suggest a good safety profile of short term oral use of Pistacia lentiscus oil as a monotherapy in the treatment of various skin, respiratory, and gastrointestinal disorders. However, due to its inhibitory effect of various cytochrome P450s and mainly CYP3A4, this might have implications on the bioavailability and metabolism of drugs taken in combination with Pistacia lentiscus oil. More attention is needed when Pistacia lentiscus oil is intended to be uses in combination with other pharmacological agents in order to avoid potential drug-drug interaction leading to toxicity. This study will help in safer use of Pistacia lentiscus oil for therapeutic purpose.

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“…Numerous studies showed that P. lentiscus mastic has impressive antibacterial and antimicrobial properties (Takahashi et al 2003). Balan et al (2007) suggested that P. lentiscus mastic gum might be developed into a chemotherapeutic agent for the treatment of human cancer colon and other cancers. Several studies further evaluated the potential antiproliferative properties of mastic gum against several types of neoplasia (Giaginis and Theocharis 2011).…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil

Eldin

Badawy

2013

J Parasit Dis

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Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis; a cosmopolitan sexually transmitted disease. Metronidazole is the drug of choice for T. vaginalis infections. The increase in metronidazole resistant parasites and undesirable side effects of this drug makes the search for an alternative a priority for the management of trichomoniasis. Pistacia lentiscus mastic and Ocimum basilicum oil are known for their antibacterial, antifungal, antiviral and antiprotozoal effects. The present study was carried out to investigate the in vitro effects of P. lentiscus mastic and O. basilicum oil on T. vaginalis trophozoites. The effects of different concentrations of P. lentiscus mastic (15, 10 and 5 mg/ml) and different concentrations of O. basilicum oil (30, 20 and 10 lg/ml) on multiplication of trophozoites at different time points (after 24, 48, 72 and 96 h) were determined, also morphological changes were reported by transmission electron microscopy (TEM). The results showed that both plants caused an inhibition of growth of T. vaginalis trophozoites. The minimal lethal concentration of P. lentiscus mastic was 15 mg/ml after 24 h incubation, 10 mg/ml after 48 h and 5 mg/ml after 96 h. The minimal lethal concentration of O. basilicum oil was 30 lg/ml after 24 h incubation, 20 lg/ml after 48 h and 10 lg/ml after 96 h. TEM study of trophozoites treated by P. lentiscus mastic or by O. basilicum oil showed considerable damage of the membrane system of the trophozoites, and extensive vacuolization of the cytoplasm. These results highly suggest that P. lentiscus mastic and O. basilicum oil may be promising phytotherapeutic agents for trichomoniasis treatment.

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Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia

Cited by 137 publications

References 33 publications

Chios Mastic Gum and Its Food Applications

Chios Mastic Gum and Its Food Applications

Short-Term Effects of Oral Administration of <b><i>Pistacia Lentiscus</i></b> Oil on Tissue-Specific Toxicity and Drug Metabolizing Enzymes in Mice

In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil

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