Antiproliferative activity of aqueous and polyphenol-rich extracts of <i>Larrea divaricata</i> Cav. on a melanoma cell line

Martino, Renzo; Arcos, Marı́a Laura Barreiro; Peralta, Ignacio; Marrassini, Carla; Martin, Elina Malen Saint; Cogoi, Laura; Cremaschi, Graciela; Alonso, María R.; Anesini, Claudia

doi:10.1080/14786419.2021.1980789

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditional Chinese medicine and its active molecules can inhibit the viability of tumor cells by regulating several important signal transduction pathways, including apoptosis, autophagy and polyamine metabolism [49][50][51]. Quercetin-3-methyl ether is a flavonoid widely present in traditional Chinese medicinal materials such as Bupleurum and Mulberry leaves, and is widely present in nature and daily diet [28]. Quercetin-3-methyl ether has been reported to inhibit the growth of a variety of malignancies, however, little is known about the functional effects of this compound on CRC cells and its antitumor mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…In recent decades, many countries have utilized multiple forms of complementary and alternative medicine to combat cancer [26,27]. Quercetin-3methyl ether (Q3ME), a natural compound found in various plants, including Caesalpinia Bonduc, Larrea Divaricata Cav., Cistus Laurifolius, Polygonum amphibium [28][29][30][31], has been shown to have anti-oxidant, anti-inflammatory, anti-viral, hypoglycemic and immunomodulatory effects [32][33][34][35][36]. Most interestingly, Quercetin-3-methyl ether has obtained wide attention in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling

Zeng,

Zhang,

Fang

et al. 2024

Int. J. Med. Sci.

View full text Add to dashboard Cite

Dysregulation of cellular metabolism is a key marker of cancer, and it is suggested that metabolism should be considered as a targeted weakness of colorectal cancer. Increased polyamine metabolism is a common metabolic change in tumors. Thus, targeting polyamine metabolism for anticancer therapy, particularly polyamine blockade therapy, has gradually become a hot topic. Quercetin-3-methyl ether is a natural compound existed in various plants with diverse biological activities like antioxidant and antiaging. Here, we reported that Quercetin-3-methyl ether inhibits colorectal cancer cell viability, and promotes apoptosis in a dose-dependent and time-dependent manner. Intriguingly, the polyamine levels, including spermidine and spermine, in colorectal cancer cells were reduced upon treatment of Quercetin-3-methyl ether. This is likely resulted from the downregulation of SMOX, a key enzyme in polyamine metabolism that catalyzes the oxidation of spermine to spermidine. These findings suggest Quercetin-3-methyl ether decreases cellular polyamine level by suppressing SMOX expression, thereby inducing colorectal cancer cell apoptosis. Our results also reveal a correlation between the anti-tumor activity of Quercetin-3-methyl ether and the polyamine metabolism modulation, which may provide new insights into a better understanding of the pharmacological activity of Quercetin-3-methyl ether and how it reprograms cellular polyamine metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling

Zeng,

Zhang,

Fang

et al. 2024

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that polyphenols demonstrate anticancer properties on melanoma cell lines via their cytotoxic and anti-proliferative effects and also by participating in the regulation of cell cycle, apoptosis and autophagy [ 22 ]. Martino et al [ 23 ] suggested that the extract from Larrea divaricata Cav. could be an adjunctive therapy for melanoma due to its high content of polyphenols and their inhibitory effect on the proliferation of B6F10 cells via the inhibition of STAT3 and the induction of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field

Kimsa-Dudek

Synowiec-Wojtarowicz

Krawczyk

et al. 2022

IJMS

View full text Add to dashboard Cite

The induction of apoptosis is one of the main goals of the designed anti-cancer therapies. In recent years, increased attention has been paid to the physical factors such as magnetic fields and to the natural bioactive compounds and the possibilities using them in medicine. Hence, the aim of this study was to evaluate the anti-tumor effect of caffeic or chlorogenic acid in combination with a moderate-strength static magnetic field on C32 melanoma cells by assessing the effect of both factors on the apoptotic process. The apoptosis of the C32 cells was evaluated using a flow cytometry analysis. The expression of the apoptosis-associated genes was determined using the RT-qPCR technique. The caspase activity and the concentration of the oxidative damage markers were also measured. It was found that phenolic acids and a static magnetic field trigger the apoptosis of the C32 cells and also affect the expression of the genes encoding the apoptosis regulatory proteins. In conclusion, our study indicated that both of the phenolic acids and a static magnetic field can be used supportively in the treatment of melanoma and that caffeic acid is more pro-apoptotic than chlorogenic acid.

show abstract

Melanoma Cellular Signaling Transduction Pathways Targeted by Polyphenols Action Mechanisms

et al. 2023

View full text Add to dashboard Cite

Melanoma is the most aggressive type of skin cancer. Although different anti-melanoma treatments are available, their efficacy is still improvable, and the number of deaths continues to increase worldwide. A promising source of antitumor agents could be presented by polyphenols—natural plant-based compounds. Over the past decades, many studies have described multiple anticancer effects of polyphenols in melanoma, presenting their potential interactions with targeted molecules from different signaling pathways. However, to our knowledge, there is no comprehensive review on polyphenols-regulated mechanisms in melanoma cells available in the literature. To fulfill this gap, this article aims to summarize the current knowledge of molecular mechanisms of action regulated by polyphenols involved in melanoma initiation and progression. Here, we focus on in vitro and in vivo effects of polyphenol treatments on tumor-essential cellular pathways, such as cell proliferation, apoptosis, autophagy, inflammation, angiogenesis, and metastasis. Moreover, emerging studies regarding the well-marked role of polyphenols in the regulation of microRNAs (miRNAs), highlighting their contribution to melanoma development, are also epitomized. Finally, we hope this review will provide a firm basis for developing polyphenol-based therapeutic agents in melanoma treatment.

show abstract

Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. on a melanoma cell line

Cited by 3 publications

References 15 publications

Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling

Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling

The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field

Melanoma Cellular Signaling Transduction Pathways Targeted by Polyphenols Action Mechanisms

Contact Info

Product

Resources

About