Antiproliferative Activity of Cyclosporin a on Human T-Lymphoblastic Leukaemia Cell Line

Foa, P.; Maiolo, Anna Teresa; Baldini, Luca; Maisto, A.; Spanò, Marcello; Starace, Giuseppe; Palo, F. Quarto Di; Polli, E.

doi:10.1016/s0140-6736(81)92712-4

The Lancet

1981

DOI: 10.1016/s0140-6736(81)92712-4

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Antiproliferative Activity of Cyclosporin a on Human T-Lymphoblastic Leukaemia Cell Line

P. Foa¹,

Anna Teresa Maiolo

Luca Baldini

et al.

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1982

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Cited by 12 publications

(2 citation statements)

References 6 publications

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“…Its inhibitory effect on the growth of a human leukemia cell line was reported by Foa et al (3). Totterman et al (4) found it was selectively cytotoxic and cytostatic on the Sezary cells.…”

mentioning

confidence: 75%

Remission of Sézary´s syndrome with cyclosporin A. Mild capillary leak syndrome as an unusual side effect

Ramon,

Betlloch,

Jimenez

et al. 1986

Acta Derm Venereol

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“…Its inhibitory effect on the growth of a human leukemia cell line was reported by Foa et al (3). Totterman et al (4) found it was selectively cytotoxic and cytostatic on the Sezary cells.…”

mentioning

confidence: 75%

Remission of Sézary´s syndrome with cyclosporin A. Mild capillary leak syndrome as an unusual side effect

Ramon,

Betlloch,

Jimenez

et al. 1986

Acta Derm Venereol

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“…A direct inhibitory effect of cyclosporin A on the growth of a human leukaemia cell line was reported by Foa et al in 1981. Totterman et al (1982 looked further at its effect on malignant T lymphocytes in vitro, finding that cyclosporin A was selectively cytotoxic and cytostatic to the abnormal cells of the Sezary syndrome.…”

mentioning

confidence: 92%

Treatment of Sézary Syndrome with Cyclosporin A

1983

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Pharmacological modification of multi‐drug resistance (mdr) in vitro detected by a novel fluorometric microculture cytotoxicity assay. Reversal of resistance and selective cytotoxic actions of cyclosporin a and verapamil on mdr leukemia t‐cells

Larsson¹,

Nygren²

1990

Intl Journal of Cancer

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A novel fluorometric microculture cytotoxicity assay (FMCA), based on measurements of fluorescein diacetate (FDA) hydrolysis and DNA staining by Hoechst 33342, was used for drug sensitivity testing and detection of resistance reversal in acute lymphoblastic leukemia (ALL) cell lines. The 72-hr assay was found to be sensitive, reproducible and linearly related to the number of viable cells within a broad range of cell concentrations. At clinically achievable drug concentrations, the calcium channel blocker Verapamil (ver) and the immunosuppressant Cyclosporin A (csA) were found to partly reverse acquired Vincristine (vcr) resistance in multi-drug resistant (MDR) T-ALL L100 cells with little or no effect on the drug-sensitive parental L0 cell line. By combining the fluorometric indices, we found that low concentrations of csA were growth-inhibitory, whereas higher concentrations (greater than 10 micrograms/ml) were progressively cytotoxic for drug-sensitive L0 cells. In MDR L100 cells, on the other hand, csA produced significant cell kill even at low drug concentrations. Ver had no effects on sensitive L0 cells but showed considerable cytotoxic action towards MDR L100 cells. There was no apparent relationship between drug reversal of vcr resistance and the cytotoxic actions of the drug per se since the calcium channel blocker diltiazem (dil) significantly potentiated the actions of vcr on MDR L100 cells without being more toxic to these cells (compared to vcr-sensitive L0 cells).

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Antiproliferative Activity of Cyclosporin a on Human T-Lymphoblastic Leukaemia Cell Line

Cited by 12 publications

References 6 publications

Remission of Sézary´s syndrome with cyclosporin A. Mild capillary leak syndrome as an unusual side effect

Remission of Sézary´s syndrome with cyclosporin A. Mild capillary leak syndrome as an unusual side effect

Treatment of Sézary Syndrome with Cyclosporin A

Pharmacological modification of multi‐drug resistance (mdr) in vitro detected by a novel fluorometric microculture cytotoxicity assay. Reversal of resistance and selective cytotoxic actions of cyclosporin a and verapamil on mdr leukemia t‐cells

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