Antiproliferative activity of isolated compounds from Pinus dalatensis and Pinus krempfii on acute myeloid Leukemia cells

Abstract

Our previous chemical constituent study of Pinus dalatensis and Pinus krempfii had identified six compounds 1-6. The continuing investigation of biological activity of the conifer species led to discovery of the antiproliferative activity of all isolated compounds 1-6 on acute myeloid leukemia cells as shown by the effects on cell cycle progression. Remarkably, compound 3 (chrysin) exibited potent bioactivity at the concentration of 10 µg/mL.