Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20

Abarzua, Sibylle; Serikawa, Tatsuo; Szewczyk, Marlen; Richter, Dagmar; Piechulla, Birgit; Briese, Volker

doi:10.1007/s00404-011-2120-6

Cited by 24 publications

(18 citation statements)

References 24 publications

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“…The preference of estradiol over enterolactone for the ER could ensure that enterolactone will not perform its anti-proliferative and apoptotic effects, thus tumor growth is increased in these mice. In vitro studies have shown that enterolactone can inhibit tumor growth in MCF-7 cell lines, with high concentrations of enterolactone inhibiting cellular proliferation by 97% compared to 60% by matairesinol; however at low concentrations (1 × 10 −5 to 1 × 10 −7 mol/L) a stimulatory effect was seen [21]. In vivo studies with MCF-7 xenograft models have shown that mice fed a soy protein diet had increased tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model

et al. 2013

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Global metabolomics analysis has the potential to uncover novel metabolic pathways that are differentially regulated during carcinogenesis, aiding in biomarker discovery for early diagnosis and remission monitoring. Metabolomics studies with human samples can be problematic due to high inter-individual variation; however xenografts of human cancers in mice offer a well-controlled model system. Urine was collected from a xenograft mouse model of MCF-7 breast cancer and analyzed by mass spectrometry-based metabolomics to identify metabolites associated with cancer progression. Over 10 weeks, 24 h urine was collected weekly from control mice, mice dosed with estradiol cypionate (1 mg/mL), mice inoculated with MCF-7 cells (1 × 107) and estradiol cypionate (1 mg/mL), and mice dosed with MCF-7 cells (1 × 107) only (n = 10/group). Mice that received both estradiol cypionate and MCF-7 cells developed tumors from four weeks after inoculation. Five urinary metabolites were identified that were associated with breast cancer; enterolactone glucuronide, coumaric acid sulfate, capric acid glucuronide, an unknown metabolite, and a novel mammalian metabolite, “taurosebacic acid”. These metabolites revealed a correlation between tumor growth, fatty acid synthesis, and potential anti-proliferative effects of gut microbiota-metabolized food derivatives. These biomarkers may be of value for early diagnosis of cancer, monitoring of cancer therapeutics, and may also lead to future mechanistic studies.

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Section: Discussionmentioning

confidence: 99%

Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model

et al. 2013

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“…The preventive role of PhyEs if assumed during adolescence was also supported by the result of a study showing that intake of PhyEs during adolescence among Ontario women was associated with a reduced risk of developing breast cancer (Anderson et al, 2013). Intake of lignans was also associated with a reduced risk of developing breast cancer (Abarzua et al, 2012), moreover enterodiol and enterolactone, alone or in combination with tamoxifen, seemed to reduce human breast cancer cell adhesion, invasion and migration in vitro (Chen and Thopmson, 2003). However, the estrogenic behavior of enterolignans is not fully clear.…”

Section: Natural Xenoestrogensmentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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“…For many isolated phytoestrogens, anti-cancerous effects have been documented in vitro and in vivo. Secoisolariciresinol, matairesinol [16] and genistein [17] are known to inhibit cell growth in MCF7 cell cultures. Several animal studies have shown a reduction of tumour growth, e.g.…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolites in Flax Root Extracts at Various Stages of Maturity and Effects on Proliferation and Cytotoxicity in Oestrogen-Receptor-Positive Breast Cancer Cells

Szewczyk¹,

Strater²,

Schlichting³

et al. 2014

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Flax contains large amounts of hormone-like compounds, especially lignans. These so-called phytoestrogens are thought to inhibit the cell growth of hormone-sensitive cancers. Hence, we analysed the influence of flax root extracts at various stages of maturity on the proliferation and cytotoxicity in oestrogen-receptor-positive breast cancer cells (MCF7) in vitro. Flax root extracts were prepared by using lignan extraction. The extracted compounds were analysed by Pyrolysis-Field Ionisation Mass Spectrometry. Various extract concentrations were applied to the cells to test for proliferation (BrdU test) and cytotoxicity (LDH test). A significantly higher inhibition of cell proliferation was observed with an extract made from 9-week-old flax roots in comparison with that of 3-and 6-week-old roots. Older roots contained more lignans and other phenolic substances than younger roots. The maturity grade of plants or their various parts is thus important for the production and concentration of secondary metabolites and leads to different biological effects on breast cancer cell growth. Keywords 92

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Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20

Abstract: The human lignans enterodiol and enterolactone are more biologically active than their precursors secoisolariciresinol and matairesinol, and may be defined as the real drugs in cancer prevention.

Cited by 24 publications

References 24 publications

Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model

Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model

Risks and benefits related to alimentary exposure to xenoestrogens

Secondary Metabolites in Flax Root Extracts at Various Stages of Maturity and Effects on Proliferation and Cytotoxicity in Oestrogen-Receptor-Positive Breast Cancer Cells

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