Antiproliferative activity of moringa oleifera's leaves ethanolic extract and docetaxel on lncap cell line and on the level of tumor necrosis factor-related apoptosis-inducing ligand

Abstract

Background: Cancer is abnormal cells growth that is responsible for the majority of global deaths and cancer is expected to rank as leading cause of death and the single most important barrier to increasing life expectancy in every country of the world in the 21st century. According to the estimates from the world health organization in 2015, cancer is the first or second leading cause of death before age 70 years in 91 of 172 countries, and it ranks third or fourth in an additional 22 countries. Many anti-cancer drugs in current use such as paclitaxel, vincristine, and vinblastine are naturally derived agents. The aim of this study is to determine the effects of ethanolic leaves extract of Moringa oleifera and docetaxel each separately and in combinations on the proliferation of LNCaP cell line, and on the level of tumor necrosis factor related apoptosis induced ligand (TRAIL). Methods: This work was performed in the laboratory of cancer research at college of medicine\ university of Babylon during the period from January 2021 to October 2021. The study was approved by the ethics committee in the college of medicine at university of Babylon.