2015
DOI: 10.1016/j.bmcl.2015.05.031
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Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells

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Cited by 23 publications
(8 citation statements)
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“…2 Chelerythrine and sanguinarine, as they are commercially available, have been investigated worldwide and their ability to inhibit some important enzymes in cancer cell division has been demonstrated many times. [3][4][5] Macarpine, which is found in plants in very small amounts, was first artificially prepared by T. Ishikawa 6 . This alkaloid and its derivatives also show strong cytotoxic effects in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…2 Chelerythrine and sanguinarine, as they are commercially available, have been investigated worldwide and their ability to inhibit some important enzymes in cancer cell division has been demonstrated many times. [3][4][5] Macarpine, which is found in plants in very small amounts, was first artificially prepared by T. Ishikawa 6 . This alkaloid and its derivatives also show strong cytotoxic effects in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, presence of the quaternary nitrogen (methylated) significantly reduced the activity of several compounds (compare especially pairs 5f and 7f , 5g and 7g , 5h or 7h ). According to previous studies, the activity of benzo[ c ]phenanthridine alkaloids can be explained by the presence of a cationic quaternary nitrogen [ 12 , 15 ]. These conclusions however probably cannot be applied to phenanthridines, because many of these compounds with a quaternary nitrogen have poor activity and one of the most potent compounds ( 5k ) does not contain a quaternary nitrogen at all.…”
Section: Resultsmentioning
confidence: 99%
“…Other systematic studies examined the correlation between the type of substituents at positions 2, 3, 7, 8 and 9 of their skeletons and antiproliferative activity [ 14 ] and revealed that cationic iminium alkaloids displayed stronger activity than their corresponding uncharged bases. The cytotoxic activity was further increased if these quaternary bases were 7,8-oxygenated [ 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…R. Br ( 13 ).. CHEs have shown a variety of effects, including antitumor ( 14 ), antibacterial ( 12 ), anti-inflammatory ( 11 ), pesticidal, and antihepatic fibrosis effects ( 15 ) and certain protective effects against diabetic cardiomyopathy ( 16 ). In terms of antitumor effect, CHE can inhibit proliferation ( 17 ) and induce apoptosis ( 18 ) on various human tumor cell lines, such as lung cancer ( 19 ), liver cancer ( 20 ), breast cancer ( 14 ) cell lines, indicating that CHE has great research value and development prospects.…”
Section: Introductionmentioning
confidence: 99%