Antiproliferative Activity of Silver Nanoplates on Human Promyelocytic Leukemia Cell Lines

Sakaguchi, Tatsuya; Mine, Kenta; Kudoh, Fuki; Kamada, Rui; Sakaguchi, Kazuyasu

doi:10.1246/cl.141085

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…Silver nanostructures, including nanoplates, are renowned for their diverse applications [47]. The distinct optical properties of silver nanoplates, like surface plasmon resonance [3,41], along with their physiological attributes, including antibacterial and anticancer activities [11,48], are intricately tied to their size and shape. Consequently, our research offers promising avenues for developing a range of functional silver nanostructures.…”

Section: Discussionmentioning

confidence: 99%

“…The ability to control the shape and size of inorganic nanostructures is critical for material science and nanotechnology, since these properties have substantial impacts on the functional attributes of the synthesized materials [1][2][3][4]. It has been shown that material morphology influences a wide array of the functional properties of nanostructures, including optical, electrical, catalytic, and biological, among others [5][6][7][8][9][10][11]. The use of biomolecules, such as biomineralization peptides, for the synthesis of inorganic nanostructures has gained popularity due to their inherent capacity to self-assemble, combined with their ability to chelate a wide variety of different metal ions [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Biomineralization through a Symmetry-Controlled Oligomeric Peptide

Sakaguchi,

Nakagawa,

Mine

et al. 2023

Biomimetics

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Biomineralization peptides are versatile tools for generating nanostructures since they can make specific interactions with various inorganic metals, which can lead to the formation of intricate nanostructures. Previously, we examined the influence that multivalency has on inorganic structures formed by p53 tetramer-based biomineralization peptides and noted a connection between the geometry of the peptide and its ability to regulate nanostructure formation. To investigate the role of multivalency in nanostructure formation by biomineralization peptides more thoroughly, silver biomineralization peptides were engineered by linking them to additional self-assembling molecules based on coiled-coil peptides and multistranded DNA oligomers. Under mild reducing conditions at room temperature, these engineered biomineralization peptides self-assembled and formed silver nanostructures. The trimeric forms of the biomineralization peptides were the most efficient in forming a hexagonal disk nanostructure, with both the coiled-coil peptide and DNA-based multimeric forms. Together, the results suggest that the spatial arrangement of biomineralization peptides plays a more important role in regulating nanostructure formation than their valency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomineralization through a Symmetry-Controlled Oligomeric Peptide

Sakaguchi,

Nakagawa,

Mine

et al. 2023

Biomimetics

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“…Cell cycle analysis was performed as described previously [ 13 ]. Briefly, 1 × 10 6 HL-60 cells were seeded on a 10-cm tissue culture dish with 10 ml of medium and incubated for 24 h before TAP-4PH treatment.…”

Section: Methodsmentioning

confidence: 99%

Effective Cellular Morphology Analysis for Differentiation Processes by a Fluorescent 1,3a,6a-Triazapentalene Derivative Probe in Live Cells

et al. 2016

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Nuclear and cytoplasmic morphological changes provide important information about cell differentiation processes, cell functions, and signal responses. There is a strong desire to develop a rapid and simple method for visualizing cytoplasmic and nuclear morphology. Here, we developed a novel and rapid method for probing cellular morphological changes of live cell differentiation process by a fluorescent probe, TAP-4PH, a 1,3a,6a-triazapentalene derivative. TAP-4PH showed high fluorescence in cytoplasmic area, and visualized cytoplasmic and nuclear morphological changes of live cells during differentiation. We demonstrated that TAP-4PH visualized dendritic axon and spine formation in neuronal differentiation, and nuclear structural changes during neutrophilic differentiation. We also showed that the utility of TAP-4PH for visualization of cytoplasmic and nuclear morphologies of various type of live cells. Our visualizing method has no toxicity and no influence on the cellular differentiation and function. The cell morphology can be rapidly observed after addition of TAP-4PH and can continue to be observed in the presence of TAP-4PH in cell culture medium. Moreover, TAP-4PH can be easily removed after observation by washing for subsequent biological assay. Taken together, these results demonstrate that our visualization method is a powerful tool to probe differentiation processes before subsequent biological assay in live cells.

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“…Interestingly, the shape of the nanoparticles also affects their toxicity to tumor cells. Sakaguchi et al showed that the shape of Ag nanomaterials plays an important role in its anti-proliferative activity, and the activity of antiproliferative silver nanomaterials highly depends on its nanostructure [115]. The Ag nanoplates have significantly higher anti-proliferative activity against human promyelocytic leukemia HL-60 cells than spherical nanoparticles.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Development and application of nanomaterials, nanotechnology and nanomedicine for treating hematological malignancies

Wang

Han

et al. 2023

J Hematol Oncol

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Hematologic malignancies (HMs) pose a serious threat to patients’ health and life, and the five-year overall survival of HMs remains low. The lack of understanding of the pathogenesis and the complex clinical symptoms brings immense challenges to the diagnosis and treatment of HMs. Traditional therapeutic strategies for HMs include radiotherapy, chemotherapy, targeted therapy and hematopoietic stem cell transplantation. Although immunotherapy and cell therapy have made considerable progress in the last decade, nearly half of patients still relapse or suffer from drug resistance. Recently, studies have emerged that nanomaterials, nanotechnology and nanomedicine show great promise in cancer therapy by enhancing drug targeting, reducing toxicity and side effects and boosting the immune response to promote durable immunological memory. In this review, we summarized the strategies of recently developed nanomaterials, nanotechnology and nanomedicines against HMs and then proposed emerging strategies for the future designment of nanomedicines to treat HMs based on urgent clinical needs and technological progress.

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Antiproliferative Activity of Silver Nanoplates on Human Promyelocytic Leukemia Cell Lines

Cited by 7 publications

References 19 publications

Biomineralization through a Symmetry-Controlled Oligomeric Peptide

Biomineralization through a Symmetry-Controlled Oligomeric Peptide

Effective Cellular Morphology Analysis for Differentiation Processes by a Fluorescent 1,3a,6a-Triazapentalene Derivative Probe in Live Cells

Development and application of nanomaterials, nanotechnology and nanomedicine for treating hematological malignancies

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