Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells

Lee, Mi Kyeong; Ha, Na Ry; Yang, Hyun-Jin; Sung, Sang Hyun; Kim, Chan Yun; Kim, Young Choong

doi:10.1016/j.phymed.2007.10.004

Cited by 55 publications

(41 citation statements)

References 22 publications

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“…Wedelolactone, caffeic acid, and stigmasterol, which have been reported as major components of methanol/ethanol extracts of E. prostrata L. [12, 21], were not present in WEP. This result indicated that active ingredients of WEP are different from those of methanol/ethanol extracts of E. prostrata L., and this may account for their different biological activities [12, 21]. …”

Section: Resultsmentioning

confidence: 99%

“…However, essential oils and methanol extracts of natural products exhibit different biological properties depending on the collection location and reveal seasonal variations [12, 21, 39]. It has been found recently that rosemary constitutes a biomass available for the development of oil-free extracts.…”

Section: Discussionmentioning

confidence: 99%

“…The plant has a folk reputation in Taiwan as a remedy for the treatment of bleeding, hemoptysis and itching, hepatitis, diphtheria, and diarrhea. Stigmasterol, caffeic acid, and wedelolactone have been determined as markers of E. prostrata L. Methanol extracts E. prostrata L. have been used to treat jaundice, leishmaniasis [19], mouse osteoblast differentiation [20], and hepatic stellate cell proliferation [21]. Water extract of E. prostrate L. (WEP) showed a significant reduction in total cholesterol, triglyceride, total protein, and elevation in high-density lipoprotein cholesterol concentrations [22, 23].…”

Section: Introductionmentioning

confidence: 99%

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Potent Antioxidative and UVB Protective Effect of Water Extract ofEclipta prostrataL.

Chan

Wen-ying

Guo

et al. 2014

The Scientific World Journal

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Oxidative stress, including Ultraviolet (UV) irradiation-induced skin damage, is involved in numerous diseases. This study demonstrates that water extract of Eclipta prostrata L. (WEP) has a potent effect in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radicals, and chelating ferrous ion, exhibiting IC50 values of 0.23 mg/mL, 0.48 mg/mL, and 1.25 mg/mL, respectively. The WEP total phenol content was 176.45 mg gallic acid equivalents (GAE)/g sample. Chlorogenic acid, a component of the plant's active ingredients, was determined by HPLC and antioxidative assay. However, no caffeic acid, stigmasterol, or wedelolactone was present in WEP. WEP absorbs both UVA and UVB irradiation, and furthermore, the extract shows a dose-dependent response in the protection of HaCaT human keratinocytes and mouse fibroblasts 3T3 cells against UVB-induced cytotoxicity, which may result from a synergistic effect between chlorogenic acid and other active components present in WEP.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potent Antioxidative and UVB Protective Effect of Water Extract ofEclipta prostrataL.

Chan

Wen-ying

Guo

et al. 2014

The Scientific World Journal

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“…As a result, a diverse skeleton of natural products including flavonoids, alkaloids, and terpenoids have been suggested to have antifibrotic activity 15−19 . We previously reported the antifibrotic activity of triterpenoids from Eclipta prostrata 9 . In addition, many other triterpenoids have been reported to have antifibrotic activity.…”

Section: Resultsmentioning

confidence: 99%

Antifibrotic activity of triterpenoids from the aerial parts ofEuscaphis japonicaon hepatic stellate cells

Lee

Jeon

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…In relation to liver fibrosis, a diverse array of natural products including flavonoids, alkaloids and terpenoids have been suggested to have antifibrotic activity [5][6][7][8].There is therefore a growing interest in searching for antifibrotic compounds from natural products with lower adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells

et al. 2010

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The CHCl(3) fraction of Cnidium monnieri fruits significantly inhibited the proliferation of hepatic stellate cells in an in-vitro assay system employing HSC-T6 hepatic stellate cell lines. Activity-guided fractionation of the CHCl(3) fraction of C. monnieri led to the isolation of ten coumarins: osthol (1), meranzin (2), auraptenol (3), meranzin hydrate (4), 7-hydroxy-8-methoxy coumarin (5), imperatorin (6), xanthotoxol (7), xanthotoxin (8), bergapten (9) and isopimpinellin (10). Of these, compounds 1 and 6 significantly inhibited proliferation of HSCs in a time- and concentration-dependent manner. In addition, compounds 1 and 6 significantly reduced collagen content in HSC-T6 cells.

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Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells

Cited by 55 publications

References 22 publications

Potent Antioxidative and UVB Protective Effect of Water Extract ofEclipta prostrataL.

Potent Antioxidative and UVB Protective Effect of Water Extract ofEclipta prostrataL.

Antifibrotic activity of triterpenoids from the aerial parts ofEuscaphis japonicaon hepatic stellate cells

Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells

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