Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model

Küçüködük, Ali; Helvacıoğlu, Fatma; Haberal, Nihan; Dağdevıren, Attıla; Bacanli, Didem; Yılmaz, Gürsel; Akkoyun, İmren

doi:10.1016/j.jcjo.2018.02.017

Cited by 13 publications

(5 citation statements)

References 50 publications

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“…Retinol, rhodopin, canthaxanthin, xanthophylls, lutein (LUT), and zeaxanthin (ZEA) are carotenoids with potent antioxidant activities, capable of crossing the retinal pigment epithelium and accumulated in the macula and protecting against agerelated macular degeneration [58]. Carotenoids were found to improve the neovascularization and damage of both retinal cells and photoreceptor outer segment [60].…”

Section: Discussionmentioning

confidence: 99%

Pomegranate juice supports therapeutic –treatment of atorvastatin against maternal hypercholesterolemia induced retinopathy of rat offspring

El‐Sayyad

El-Gallil

El-Ghawet

2021

Egyptian Journal of Basic and Applied Sciences

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Dietary consumption of processed high fat diet led to the development of metabolic diseases. This study aimed to demonstrate the retinopathy in a rat offspring maternally fed on high cholesterol and the improvement of pomegranate juice (PJ) administration and atorvastatin as potential treatment. Eighty pregnant Wistar albino rats were categorized into eight groups (n = 10); the control, PJ supplementation [0.4 m L (20%)]; atorvastatintreatment (10 mg/kg); and hypercholesterolemia (fed on 3% cholesterol for 6 weeks prior to conception, during pregnancy and lactation period. Retinas of 21-day-old rat offspring were investigated. Offspring maternally fed on a hypercholesterolemic diet exhibited internal retinal hemorrhage at the interphase between the pigment epithelium and photoreceptors leading to retinal detachment. In addition, widespread of degenerated stacked membrane of the photoreceptor outer segment and the neovascularization within the nuclear layers were observed. Offspring retina of a hypercholesterolemic mother exhibited a significant depletion of assayed neurotransmitters coinciding with a significant increase of the vacuolar endothelial growth factor apoptotic markers expressing pressing damaging of retinal cells. Co-administration of pomegranate juice to hypercholesterolemic mother rats treated with atorvastatin significantly improved the retinal structure and the assayed biochemical markers of offspring than that with atorvastatin-treatment. In conclusion, PJ showed a potent antiapoptotic and ant-angiogenesis activity and improved the histocytological pictures of rat offspring maternally subjected to hypercholesterolemia.

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Section: Discussionmentioning

confidence: 99%

Pomegranate juice supports therapeutic –treatment of atorvastatin against maternal hypercholesterolemia induced retinopathy of rat offspring

El‐Sayyad

El-Gallil

El-Ghawet

2021

Egyptian Journal of Basic and Applied Sciences

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“…AST also offers a dose-independent reduction in mitochondrial injuries and a dose-dependent inhibition of apoptosis in a HIR newborn mouse model. e most effective route seems to be intravitreal high-dose AST injection [57]. In conclusion, AST can protect the RPE layer from oxidative damage and prevent CNV formation, thus, delaying the occurrence and development of ARMD.…”

Section: In Vivo Animal Studymentioning

confidence: 95%

“…Moreover, AST protected against increases of PI-positive cells and intracellular ROS activity in retinal core cells [48,52]. Pathological neovascularization of the retina is another important cause of choroidal neovascularization (CNV) and AMD [57]. Otsuka et al found the possibility of AST supplementation as a therapeutic strategy in suppressing CNV-associated ARMD in C57BL/6J mice [15].…”

Section: In Vivo Animal Studymentioning

confidence: 99%

Recent Advances and the Mechanism of Astaxanthin in Ophthalmological Diseases

Yang

Wang

2022

Journal of Ophthalmology

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Astaxanthin (AST) is a naturally occurring carotenoid that has strong antioxidant, anti-inflammatory, and antiapoptosis effects and is used for the prevention of cancer. There is growing evidence that AST has multiple protective effects against various eye diseases. This article reviews the function and the potential mechanism of AST in dry eye syndrome, keratitis, cataract, diabetic retinopathy, age-related macular degeneration, high intraocular pressure, and other ocular diseases. It provides a theoretical basis for the clinical application of AST as a potential nutraceutical.

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“…Oral intake of lycopene has been shown to be effective in preventing elevated inflammation and oxidative stress in the alloxan-induced diabetic eye tissues, the optic nerve in particular [ 81 ]. Astaxanthin, a xanthophyll produced by algae and found in many marine organisms, has sparked widespread interest among scientists in managing DR. Astaxanthin, either administered orally, intraperitoneally, or by intravitreal injection, is reported to suppress oxidative stress, downregulate inflammation, alleviate apoptosis, and help to improve visual acuity and control blood glucose via the phosphoinositide 3-kinase (PI3K)/Akt/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and hypoxia-inducible factor alpha (HIF-1α) pathway [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ]. Another xanthophyll, lactucaxanthin is a carotenoid from lettuce.…”

Section: Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Ye,

Fung,

Lam

et al. 2024

Nutrients

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Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage of DR before its progression into the more severe sight-threatening proliferative stage. Nutraceuticals, natural functional foods with few side effects, have been proposed to be beneficial in patients with DR. Over the decades, many studies, either in vitro or in vivo, have demonstrated the advantages of a number of nutraceuticals in DR with their antioxidative, anti-inflammatory, neuroprotective, or vasoprotective effects. However, only a few clinical trials have been conducted, and their outcomes varied. The low bioavailability and instability of many nutraceuticals have indeed hindered their utilization in clinical use. In this context, nanoparticle carriers have been developed to deliver nutraceuticals and to improve their bioavailability. Despite its preclinical nature, research of interventive nutraceuticals for DR may yield promising information in their clinical applications.

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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model

Cited by 13 publications

References 50 publications

Pomegranate juice supports therapeutic –treatment of atorvastatin against maternal hypercholesterolemia induced retinopathy of rat offspring

Pomegranate juice supports therapeutic –treatment of atorvastatin against maternal hypercholesterolemia induced retinopathy of rat offspring

Recent Advances and the Mechanism of Astaxanthin in Ophthalmological Diseases

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

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