Antiproliferative and antimicrobial activities of alkylbenzoquinone derivatives from<i>Ardisia kivuensis</i>

Paul, Dzoyem Jean; Laure, Ndontsa B.; Guru, Santosh Kumar; Khan, Inshad Ali; Ajit, Saxena K.; Vishwakarma, Ram A.; Tane, Pierre

doi:10.3109/13880209.2013.837076

Cited by 16 publications

(15 citation statements)

References 21 publications

(24 reference statements)

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“…Previous reports revealed that p -benzoquinone and several other derivatives exhibit cytotoxicity [ 20 , 21 ]. The cytotoxicity of the primary constituents of TDS, including a mixture of 2 and 3 , and compounds 1 , 4 , 5 were tested.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera

et al. 2017

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Blaps rynchopetera Fairmaire has long been used as a folk medicine by the Yi and Bai ethnic groups in China to treat fever, cough, gastritis, boils, and tumors. In the present study, the cytotoxicity of the defensive secretion (TDS) of B. rynchopetera against AGS Caco-2, HepG2 U251 and Bel-7402 was tested, and the results revealed that TDS had potent cytotoxicity against testing cells with IC50 values of 45.8, 17.4, 53.6, 98.4 and 23.4 μg/mL, respectively. Gas chromatography-mass spectrometry (GC-MS) analysis was employed to clarify the cytotoxic constituents in TDS of B. rynchopetera and five volatile compounds, including 2-ethyl-2,5-cyclohexadiene-1,4-dione (3, 31.00%), 1-tridecene (5, 28.02%), 2-methyl-2,5-cyclohexadiene-1,4-dione (2, 22.86%), hydroquinone (4, 1.33%), and p-benzoquinone (1, 1.01%), were identified. Chemical constituent investigation on TDS further supported the presence of 5 above compounds. A cytotoxic assay indicated that compounds 1, 2, 3 and 4 exhibited significant cytotoxicity against the testing cell lines, implying that benzoquinones and hydroquinone played important roles in the cytotoxicity of TDS of B. rynchopetera. TDS is a cytotoxic natural material and further studies investigating mechanisms and inhibitory activities on other cell lines is warranted.

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Section: Resultsmentioning

confidence: 99%

Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera

et al. 2017

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“…Nevertheless, microbes are crucial to the conservation of mangrove forest, tasked with fixing nitrogen and sequestering carbon, they confer fitness to trees which are rooted in nutrient-poor, waterlogged, saline and mostly acidic soil [2] . underexplored habitats such as mangroves, as sources of biologically active compounds [14][15][16] . For instance, the review by Ancheeva and colleagues highlighted that between the years of 2014 and 2018, 163 compounds isolated mostly from mangrove-derived fungi, exhibited potent anti-cancer, antimicrobial, anti-inflammatory, cholesterol lowering and α-glucosidase activity [17] .…”

Section: Introductionmentioning

confidence: 99%

Investigating the antioxidant potential of Streptomyces sp. MUSC 11 from mangrove soil in Malaysia

Kemung¹,

Tan²,

Chan³

et al. 2019

Prog Drug Discov Biomed Sci

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Streptomyces are a distinguished group of gram-positive bacteria mostly acknowledged for their immense contribution to life-saving drugs and lines of compounds with diverse bioactivities. To date, there remains limited studies on Streptomyces with biological activities residing in underexplored ecosystems such as the mangrove forests. For this purpose, the present work aimed at investigating the biological activity of Streptomyces sp. MUSC 11 collected from soil sample in mangrove forests, situated in the State of Pahang, Peninsular of Malaysia. The cultured strain resembled phenotypic and genotypic traits of genus Streptomyces. Investigations of the methanolic extract from Streptomyces sp. MUSC 11 revealed antioxidant activities in form of scavenging free radicals ABTS, DPPH, chelating iron and reducing ferric iron. Besides the antioxidant tests, antioxidant results corresponded well to the presence of phenolic content. In summary, Streptomyces derived from extreme and understudied ecosystem such as the mangrove forests are potential sources of biologically active and therapeutically useful compounds.

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“…Furthermore, medicinal plant extracts might also reduce the risk of oxidative stress and cell damage (Guizani et al, 2013). It has been reported that the increase in immune response improves the defense against various diseases, such as microbial infections and leukemia (Paul et al, 2014). Both cells and molecules of the immune system play important roles.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cytotoxicity on Human Cancer Cells and Antioxidant and Immune Cell Activities of Codonopsis lanceolata Root Extracts Stored at Different Temperatures and for Different Durations

Boo¹,

Shin²,

Kim³

et al. 2019

HST

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Codonopsis lanceolata is widely consumed in South Korea; however, its medicinal applications have not been explored in detail. The present study aimed to evaluate the xanthine oxidase (XO) inhibitory activity, reducing power, immune activity, and cytotoxicity of 30% ethanolic extracts of C. lanceolata roots stored at different temperatures (5, 15, 25, 35, and 45°C) and for different storage periods (0, 15, 30, 45, 60, 75, and 90 days). The growth of human T and B cells increased when treated with the root extracts stored at low temperatures for a short period, in a concentration-dependent manner. The XO inhibitory activity of the C. lanceolata roots stored at 5°C and 15°C was higher than for those stored at 45°C. The XO inhibitory activity of the C. lanceolata roots gradually deceased with increasing storage period. The reducing power of the extracts increased significantly in a concentration-dependent manner. Reducing power of the root storage temperature for all temperatures and storage periods using 5 mg·mL -1 extract was higher than that for the other extract concentrations. Cytotoxic activity of C. lanceolata roots on human cancer cell lines (e.g., HeLa, Calu-6, and MCF-7) decreased as storage temperatures decreased from 45°C to 5°C. The cytotoxic effect on the MCF-7 cell line was relatively higher than that on the HeLa and Calu-6 cell lines. The results suggest that the root extract of C. lanceolata can be used to modulate immune response and is also a natural food additive with excellent physiological functionality.

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Antiproliferative and antimicrobial activities of alkylbenzoquinone derivatives fromArdisia kivuensis

Cited by 16 publications

References 21 publications

Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera

Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera

Investigating the antioxidant potential of Streptomyces sp. MUSC 11 from mangrove soil in Malaysia

Evaluation of Cytotoxicity on Human Cancer Cells and Antioxidant and Immune Cell Activities of Codonopsis lanceolata Root Extracts Stored at Different Temperatures and for Different Durations

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