Antiproliferative and Antimicrobial Activities of Selected Bryophytes

Vollár, Martin; Gyovai, András; Szűcs, Péter; Zupkó, István; Marschall, Marianna; Csupor-Löffler, Boglárka; Bérdi, Péter; Vecsernyés, Anikó; Csorba, Attila; Liktor‐Busa, Erika; Urbán, Edit; Csupor, Dezső

doi:10.3390/molecules23071520

Cited by 37 publications

(27 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among these, 41 species of bryophytes performed 25 % inhibition of the proliferation of at least one of the cell lines at a concentration of 10 g mL −1 . Considering the range of concentrations tested by the present study, it is not possible to compare it with the studies cited previously, such as the one by Vollár et al ., [48] which used much higher concentrations of extracts, oils, and isolates of bryophytes than those tested here.…”

Section: Resultsmentioning

confidence: 60%

See 1 more Smart Citation

Chemical Composition and Cytotoxic Evaluation of the Essential Oil of Phyllogonium viride (Phyllogoniaceae, Bryophyta)

Klegin

Moura²,

Sousa³

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

The present study aimed to determine the chemical composition and biological activity of the essential oil obtained from Phyllogonium viride Brid. (Phyllogoniaceae, Bryophyta), whose samples were collected in southern Brazil. For the first time, the cytotoxic activity of the essential oil of P. viride in breast and colorectal tumor cells (MCF‐7 and HCT‐116) was evaluated, as well as the cytotoxic potential of this oil in non‐tumoral cells of human immortalized keratinocytes (HaCaT) via MTT assay. The compounds majorly found in P. viride essential oil were β‐bazzanene (20.30 %), β‐caryophyllene (17.06 %), β‐chamigrene (14.02), and germacrene B (11.72 %). Treatment with P. viride essential oil in the different tested cell lines did not induce any toxicity in most of the tested concentrations. These data contribute to generating new scientific information about this understudied plant species. Furthermore, the chemical characterization of the compounds present in the essential oil of P. viride can lead to greater elucidation of its biotechnological potential.

show abstract

Section: Resultsmentioning

confidence: 60%

“…moss, which demonstrated cytotoxicity against colon cancer cells (HT‐29 and SW620). Vollár et al [48] . analyzed the antiproliferative capacity of 42 bryophyte extracts on cervical, ovarian, and breast cancer cell lines.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Cytotoxic Evaluation of the Essential Oil of Phyllogonium viride (Phyllogoniaceae, Bryophyta)

Klegin

Moura²,

Sousa³

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Only a handful of studies have been carried out to investigate the bioactive potential of lower plants including bryophytes [13,21,22]. Since Sri Lanka is an isolated island with remarkable biodiversity among its flora, the density and the number of bryophyte species are very high.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and Alpha‐Amylase Inhibitory Activities of Organic Extracts of Selected Sri Lankan Bryophytes

Kirisanth

Nafas

Dissanayake

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Medicinal plants have been the main focus of natural product research. However, recent research has revealed that lower plants including bryophytes are also a major resource of biologically active compounds with novel structures. Sri Lanka is considered as a biodiversity hotspot with a higher degree of endemism flora including bryophytes. In this study, different species of bryophytes were investigated for their antimicrobial and alpha-amylase inhibitory activities. The air-dried plant materials of 6 different bryophyte species, Marchantia sp., Fissidens sp., Plagiochila sp., Sematophyllum demissum, Hypnum cupressiforme, and Calymperes motley, were subjected to sequential cold extraction with 3 different organic solvents. All three types of organic crude extracts were subjected to screening of antimicrobial bioassays using the disc-diffusion method against 3 bacterial strains and 1 fungal strain. According to the results obtained, 6 extracts out of 18 showed antibacterial activity for tested Gram-positive bacteria and 1 active against Gram-negative bacteria. Two extracts showed activity against the pathogenic fungus strain. Extracts from some plants were active against tested bacterial as well as fungal species. TLC-based bioautographic study was carried out to identify the corresponding active bands which is useful for active compound isolation. Furthermore, the ethyl acetate extracts were subjected to evaluate alpha-amylase inhibitory activity where three extracts out of six extracts showed moderate inhibitory activity for alpha-amylase with IC50 ranging 8–30%.

show abstract

“…The next stage of the research was devoted to an analysis of the changes in the cell metabolic activity during the biodegradation of selected aromatic compounds. The MTT assay, used mainly for measurements of metabolic activity of eukaryotic cells, was also applied in bacteria research [30,31]. The assay in question is based on the reduction of a yellow, water-soluble MTT reagent (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-trazolium bromide) into its purple formazan salt, but only by metabolically active cells.…”

Section: Cell Metabolic Activitymentioning

confidence: 99%

Bacterial Biodegradation of 4-Monohalogenated Diphenyl Ethers in One-Substrate and Co-Metabolic Systems

et al. 2018

View full text Add to dashboard Cite

The use of diphenyl ether (DE) and its 4-monohalogenated derivatives (4-HDE) as flame retardants, solvents, and substrates in biocide production significantly increases the risk of ecosystem contamination. Their removal is important from the point of view of environmental protection. The aim of this study was to evaluate the degradation processes of DE and 4-HDE by enzymes of the environmental bacterial strains under one-substrate and co-metabolic conditions. The study is focused on the biodegradation of DE and 4-HDE, the enzymatic activity of microbial strains, and the cell surface properties after contact with compounds. The results show that the highest biodegradation (96%) was observed for 4-chlorodiphenyl ether in co-metabolic culture with P. fluorescens B01. Moreover, the activity of 1,2-dioxygenase during degradation of 4-monohalogenated diphenyl ethers was higher than that of 2,3-dioxygenase for each strain tested. The presence of a co-substrate provoked changes in dioxygenase activity, resulting in the increased activity of 1,2-dioxygenase. Moreover, the addition of phenol as a co-substrate allowed for increased biodegradation of the diphenyl ethers and noticeable modification of the cell surface hydrophobicity during the process. All observations within the study performed have led to a deeper understanding of the contaminants’ biodegradation processes catalyzed by environmental bacteria.

show abstract

Antiproliferative and Antimicrobial Activities of Selected Bryophytes

Cited by 37 publications

References 83 publications

Chemical Composition and Cytotoxic Evaluation of the Essential Oil of Phyllogonium viride (Phyllogoniaceae, Bryophyta)

Chemical Composition and Cytotoxic Evaluation of the Essential Oil of Phyllogonium viride (Phyllogoniaceae, Bryophyta)

Antimicrobial and Alpha‐Amylase Inhibitory Activities of Organic Extracts of Selected Sri Lankan Bryophytes

Bacterial Biodegradation of 4-Monohalogenated Diphenyl Ethers in One-Substrate and Co-Metabolic Systems

Contact Info

Product

Resources

About