2024
DOI: 10.21203/rs.3.rs-4709833/v1
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Antiproliferative and apoptosis effect of Lactobacillus acidophilus on HT-29 cells accompanied by subG1 cycle arrest and modulation of mTOR/p62/FAS/Caspase8/Bax pathway

Rana Rafoogarzadeh,
Aras Rafiee,
Saba Taheri

Abstract: Lactobacillus acidophilus is the most commonly used probiotic that is paving the preventive and biotherapeutic methods for colorectal cancer. However, the mechanisms underlying its remedial utility are largely unknown. The cell viability of the HT-29 cell line under concentrations (108,109 and 1010 cfu/ml) of L. acidophilus Sonicated Extract (LSE) screened out, using the MTT assay at 24 and 72 hours. The apoptosis and cell cycle arrest were assessed via flow cytometry. A possible signaling pathway of mTOR/p62/… Show more

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