Antiproliferative and apoptosis effect of Lactobacillus acidophilus on HT-29 cells accompanied by subG1 cycle arrest and modulation of mTOR/p62/FAS/Caspase8/Bax pathway
Rana Rafoogarzadeh,
Aras Rafiee,
Saba Taheri
Abstract:Lactobacillus acidophilus is the most commonly used probiotic that is paving the preventive and biotherapeutic methods for colorectal cancer. However, the mechanisms underlying its remedial utility are largely unknown. The cell viability of the HT-29 cell line under concentrations (108,109 and 1010 cfu/ml) of L. acidophilus Sonicated Extract (LSE) screened out, using the MTT assay at 24 and 72 hours. The apoptosis and cell cycle arrest were assessed via flow cytometry. A possible signaling pathway of mTOR/p62/… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.