Antiproliferative and apoptotic effects of pinocembrin in human prostate cancer cells

Galenia africana plant extract exhibits cytotoxicity in breast cancer cells by inducing multiple programmed cell death pathways

“…Specifically, while flavanones have shown anti- oral and -breast cancer activity, chalcones have shown anti-cancer activity in oral cancer and leukemia ( Chahar et al, 2011 ). In this regard, it is worth noting that pinocembrin was also previously identified in Kraalbos extracts ( Mativandlela et al, 2009 ; Ng’uni, 2017 ; Ticha et al, 2015 ; Vries et al, 2005 ) and that pinocembrin has been shown to exhibit anti-cancer effects against a variety of cancers including colon cancer, prostate cancer and leukemia ( Chen et al, 2013 ; Kumar et al, 2007 ; Rasul et al, 2013 ). Given the known anti-cancer activity of flavonoids it is tempting to speculate that they are responsible for the anti-cancer activity exhibited by KB2 either solely or that they work synergistically with other, as yet to be identified compounds, present in the KB2 extract.…”

“…This series of events is consistent with results from other studies that have investigated the effects of oxidative stress on cancer cells ( Russo et al, 1995 ). Furthermore, pinocembrin, was also reported to induce an S-phase cell cycle arrest in LNCaP prostate cancer cells ( Chen et al, 2013 ) and a pinocembrin derivative (5-hydroxy-4-oxo-2-phenylchroman-7-yl 3,4,5-trimethoxybenzoate) exhibited anti proliferative activity in MDA-MB-231 cells ( Cappello et al, 2019 ).

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The Influence of In Vitro Gastrointestinal Digestion on the Anticancer Activity of Manuka Honey

“…Some papers that have investigated the effect on the cell cycle of some of the single compounds identified with HPLC. As regards flavonoids (which are almost completely absent in the digested fraction), pinocembrin was found to block the cell cycle of human prostatic cancer cells (LNCaP) in the S phase [53] and the same effect was observed in hepatocellular carcinoma (HepG2) [54]. Another As regards the regulation of the cell cycle by DMH, a statistically significant increase (p < 0.05) can be noted in the number of cells present in the Sub-G1 phase, including both apoptotic and oncotic cells: the percentage of cells in this phase was, respectively, 26% and 44% more than control with treatment at 16 and 24 mg/mL.…”

“…Some papers that have investigated the effect on the cell cycle of some of the single compounds identified with HPLC. As regards flavonoids (which are almost completely absent in the digested fraction), pinocembrin was found to block the cell cycle of human prostatic cancer cells (LNCaP) in the S phase [53] and the same effect was observed in hepatocellular carcinoma (HepG2) [54]. Another flavonoid found only in honey not subjected to digestion, quercetin, has shown a similar effect, blocking the CSCs derived from colorectal carcinoma (HT-29) in the S phase [55], and also in three leukemic cell lines (CEM, K562, Nalm6) and in two breast cancer cell lines (T47D and EAC) [56].…”

Proapoptotic Activity of Propolis and Their Components on Human Tongue Squamous Cell Carcinoma Cell Line (CAL-27)

“…Pinocembrin induced loss of mitochondrial membrane potential with releasing of cytochrome c and activation of caspase-3 and -9 in colon cancer cells [ 24 ]. Other results revealed that pinocembrin attenuated the cell viability of both androgen-sensitive (LNCaP) as well as androgen-independent (PC3 and DU-145) prostate cancer cell lines, with different p53 status [ 25 ]. The potency of hydroxycinnamic acids such as caffeic, ferulic, coumaric as anticancer agents, were also examined [ 26 ].…”