Antiproliferative and caspase-mediated apoptosis inducing effects of Murraya koenigii seeds against cancer cells

Nadaf, Sameer J.; Desai, Rutuja; More, Trupti; Shinde, Priyanka; Dakare, Suraj; Killedar, Suresh G.

doi:10.1016/j.sajb.2020.05.021

Cited by 7 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Methanolic extract of papaya black seed ( Carica papaya ) have been investigated for its cytotoxicity against the human liver cancer Hep G2 cell lines with (IC 50 ) value of 24.35 μg/mL, as well as shown a significant apoptotic effect by activating caspase‐3 136 . Caspase‐mediated apoptosis‐inducing effects of Murraya koenigii seeds was studied against MFC‐7 and DLD‐1 cancer cells, and the result showed significant cytotoxicity with IC50 values of 284.02 and 269.67 µg/mL, respectively, for 72 h incubation 137 . Rubus fairholmianus root acetone extract (RFRA)dose‐dependently induced apoptosis through increased activation of caspase‐3/7 against A375 and A549 cell lines 138 .…”

Section: Role Of Phytochemicals As Caspase Inducers: Natural Semisynt...mentioning

confidence: 99%

“…135 Methanolic extract of papaya black seed (Carica papaya) have been investigated for its cytotoxicity against the human liver cancer Hep 269.67 µg/mL, respectively, for 72 h incubation. 137 Rubus fairholmianus root acetone extract (RFRA)dose-dependently induced apoptosis through increased activation of caspase-3/7 against A375 and A549 cell lines. 138 The Apoptogenic effect of phyto-mediated synthesized silver nanoparticle from the dried stem of Eleutherococcus senticosus was studied against HT29 and A54 human cancer cells at a concentration of 10 µg/mL, resulting in upregulation of caspase-3.…”

Section: Other Compounds Exhibiting Superior Antineoplastic Effects T...mentioning

confidence: 99%

See 1 more Smart Citation

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Allani,

Akhilesh,

Tiwari

2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

Apoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed cell death, which plays an important role in cancer as a classical mechanism of tumor cell death causing minimal inflammation without causing damage to other cells in the vicinity. Induction of apoptosis by activation of caspases is one of the primary targets for cancer treatment. Over the years, a diverse range of natural, synthetic, and semisynthetic compounds and their derivatives have been investigated for their caspase‐mediated apoptosis‐induced anticancer activities. The review aims to compile the preclinical evidence and highlight the critical mechanistic pathways related to caspase‐induced cell apoptosis in cancer treatment. The focus is placed on the key components of the mechanisms, including their chemical nature, and specific attention is given to phytochemicals derived from natural sources and synthetic and semisynthetic compounds. 180+ compounds from the past two decades with potential as anticancer agents are discussed in this review article. By summarizing the current knowledge and advancements in this field, this review provides a comprehensive overview of potential therapeutic strategies targeting apoptosis in cancer cells. The findings presented herein contribute to the ongoing efforts to combat cancer and stimulate further research into the development of effective and targeted anticancer therapies.

show abstract

Section: Role Of Phytochemicals As Caspase Inducers: Natural Semisynt...mentioning

confidence: 99%

Section: Other Compounds Exhibiting Superior Antineoplastic Effects T...mentioning

confidence: 99%

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Allani,

Akhilesh,

Tiwari

2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Because cancer is a persistent disease, it is necessary to investigate how it affects people through clinical trials in order to introduce this product as an anticancer drug (72).…”

Section: Anticancer Activitymentioning

confidence: 99%

Unveiling the diverse medicinal properties of Murraya koenigii

Nandy,

Das

2023

sciphy

View full text Add to dashboard Cite

Since the beginning of time, nature has provided medicines for treating fatal illnesses. Herbalists believe that certain plants have medicinal qualities. In tribal and rural communities, medicinal plants provide as an easily accessible source of treatment. The identification of various rejuvenating molecules that can halt or lessen the pathology of a variety of diseases will be regarded as a significant development of the present. There has been a scientific advancement in this area, and current studies on herbal medicines and traditional cures have attracted significant interest from all over the world. This plant, popularly known as the curry tree, is frequently used as herb and is also used to treat a variety of problems in traditional Indian medicine. About 80–85% of people worldwide rely on herbal products because they are thought to be efficient, secure, and cost-effective. Reviewing the plant taxonomy, ethnobotanical characteristics, folkloric or traditional uses, phytochemical, and pharmacological qualities of the Murraya koenigii plant was the goal of the current study. The leaves are used internally for dysentery as a carminative, tonic, stomachic, and inducer of vomiting. The usage of other parts includes treating piles, preventing helminthiasis, and reducing body heat, itchiness, and inflammation. Following several reports that this plant may treat a wide range of illnesses, scientists have worked to confirm the effectiveness of this plant by biological screening. A review of the literature suggests that Murraya koenigii has various medical benefits, including activity of antimicrobial, cardiac, anti-oxidative, anti-diabetic and cholesterol reduction, cytotoxic action, antiulcer, and anti-diarrhea.

show abstract

“…It is widely used to cure rheumatism, traumatic injury, and snakebite [20]. This plant extract and few compounds isolated from it have been proven to have anticancer potential, particularly in breast cancer [21][22][23][24]. Studies have shown that the leaves of this plant have many other pharmacological benefits, such as immunomodulatory, anti-bacterial, anti-fungal, antiprotozoal, antioxidant, and hypolipidemic activity, etc.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Mahanimbine from Curry Leaves in Human Breast Cancer Cells (MCF-7) via Mitochondrial Apoptosis and Anti-Angiogenesis

Hobani

2022

Molecules

View full text Add to dashboard Cite

Mahanimbine (MN) is a carbazole alkaloid present in the leaves of Murraya koenigii, which is an integral part of medicinal and culinary practices in Asia. In the present study, the anticancer, apoptotic and anti-invasive potential of MN has been delineated in vitro. Apoptosis cells determination was carried out utilizing the acridine orange/propidium iodide double fluorescence test. During treatment, caspase-3/7,-8, and-9 enzymes and mitochondrial membrane potentials (Δψm) were evaluated. Anti-invasive properties were tested utilizing a wound-healing scratch test. Protein and gene expression studies were used to measure Bax, Bcl2, MMP-2, and -9 levels. The results show that MN could induce apoptosis in MCF-7 cells at 14 µM concentration IC50. MN-induced mitochondria-mediated apoptosis, with loss in Δψm, regulation of Bcl2/Bax, and accumulation of ROS (p ≤ 0.05). Caspase-3/7 and -9 enzyme activity were detected in MCF-7 cells after 24 and 48 h of treatment with MN. The anti-invasive property of MN was shown by inhibition of wound healing at the dose-dependent level and significantly suppressed mRNA and protein expression on MMP-2 and -9 in MCF-7 cells treated with a sub-cytotoxic dose of MN. The overall results indicate MN is a potential therapeutic compound against breast cancer as an apoptosis inducer and anti-invasive agent.

show abstract

Antiproliferative and caspase-mediated apoptosis inducing effects of Murraya koenigii seeds against cancer cells

Cited by 7 publications

References 40 publications

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Unveiling the diverse medicinal properties of Murraya koenigii

Cytotoxicity of Mahanimbine from Curry Leaves in Human Breast Cancer Cells (MCF-7) via Mitochondrial Apoptosis and Anti-Angiogenesis

Contact Info

Product

Resources

About