Antiproliferative and Cytotoxic Activities

Sesquiterpene Lactones and Diterpenes: Promising Therapeutic Candidates for Infectious Diseases, Neoplasms and Other Chronic Disorders

“…Other sesquiterpene lactones with promising activity and which are under study are parthenolide and its analog dimethylamino-parthenolide, which are active against breast cancer cells, leukemia and pancreatic carcinoma cells; artemisinin, which has been studied for the treatment of different types of cancers such as breast and colorectal cancer [ 3 , 4 ]; and dehydrocostuslactone and costunolide for breast cancer and leukemia [ 5 ]. Other sesquiterpene lactones such as psilostachyin, psilostachyin C, helenalin, mexicanin, cumanin, deoxymikanolide, lychnopholide and goyazensolide were found to be active against tumor cell lines and against Trypanosoma cruzi , the causative agent of Chagas disease [ 6 , 7 , 8 , 9 ].…”