Antiproliferative effect of aqueous bark extract of Oroxylum indicum L. on Vigna radiata L. (Green gram) seedlings

Chetry, Luk Bahadur; Bharali, Manuj Kr

doi:10.31254/phyto.2018.7212

Cited by 6 publications

(2 citation statements)

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“…The plant's seed and root include tetuin and 6-glucosides of baicalein, as well as oroxindin (Harminder et al 2011, Jagetia 2021, Lodh and Swamy 2020, Nair et al 1979). The plant's stem bark extract contains alkaloids, flavonoids, phenolic chemicals, saponins, and carbohydrates (Chetry and Bharali 2018, Pathak et al 2020, Samatha et al 2012.…”

Section: Plant Profile and Usesmentioning

confidence: 99%

Phytochemical analysis and ethnomedicinal uses of Oroxylum indicum in Nepal

Bhattarai¹

2022

Ethnobot. Res. App.

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Background: Plant natural products have a long history of usage as a source of therapeutic agents. Oroxylum indicum (L.) Kurz is a prominent therapeutic plant in South Asia, comprising several phytochemicals with substantial medical significance, including the treatment of COVID-19.Methods: Herein, we documented the medicinal importance of O. indicum throughout Nepal using a questionnairebased survey and and validated the findings through biochemical analyses.Results: All fractions (water, hexane and dichloromethane) obtained from different extraction solvents revealed a high abundance of alkaloids, flavonoids, phenolic compounds, saponins, and carbohydrates that is consistent with its vast ethnomedicinal uses generated through the questionnaire survey.Conclusions: In a nutshell, O. indicum is a promising medicinal plant based on our current experiment, and more research on ethnomedicinal and plant biochemical capabilities might lead to new scientific avenues and novel drug discoveries. It further paves the scope of documentation of traditional knowledge for the benefit of local and national communities.

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Section: Plant Profile and Usesmentioning

confidence: 99%

Phytochemical analysis and ethnomedicinal uses of Oroxylum indicum in Nepal

Bhattarai¹

2022

Ethnobot. Res. App.

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“…O. indicum and its favonoid constituents have been reported to possess a wide range of biological and pharmacological activities [8,[10][11][12][13][14][15]. Over recent years, O. indicum has attracted a growing interest in treating various cancer cells, focusing on inhibiting cell division and proliferation [6,[16][17][18][19][20]. Talari et al have demonstrated the antiangiogenic efect of O. indicum on VEGF-induced neovascularization in the CAM model [21].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative, Antiangiogenic, and Antimigrastatic Effects of Oroxylum indicum (L.) Kurz Extract on Breast Cancer Cell

Chiraatthakit,

Dunkunthod,

Suksaweang

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Breast cancer recurrence continues to pose a major clinical problem, despite significant advancements in early diagnosis and an aggressive mode of treatment. This study aimed at investigating the anticancer activity of Oroxylum indicum extract (OIE) by assessing cell proliferation, cell migration, and angiogenesis in metastatic breast cancer MDA-MB-231 cell lines. This study also estimated the phytochemical profiles of OIE by LC-QTOF-MS. The extract was found to contain six identified flavonoid substances, and baicalein was the most abundant substance in the extract. Cell proliferation capacity was performed by cell counting kit-8 (CCK-8) and colony formation assays. The effect of OIE on cell migration was determined using wound healing and transwell assays. Meanwhile, MDA-MB-231-induced angiogenesis on chick chorioallantoic membrane (CAM) was applied to investigate the ex vivo antiangiogenesis activity of the extracts. OIE at concentrations lower than 600 μg/mL had no cytotoxic effects against MDA-MB-231 cells. OIE was found to inhibit the long-term colony formation ability of MDA-MB-231 cells in a concentration-dependent manner. Antimigration and antiangiogenesis activities were further investigated using noncytotoxic concentrations of OIE ranging from 25 to 150 μg/mL. OIE greatly reduced the migration of MDA-MB-231 breast cancer cells in a dose-dependent manner. OIE significantly suppressed the MDA-MB-231-induced angiogenesis, and there was no substantial toxic effect on natural angiogenesis. Interestingly, the concentration of OIE at 150 μg/mL was as practically potent as pazopanib, the positive anticancer drug, at 4.37 μg/mL in inhibiting MDA-MB-231 cell migration and angiogenesis induced by these cells. Therefore, the inhibitory effects of OIE in cell proliferation and cell migration, together with antiangiogenesis in MDA-MB-231 breast cancer cells, suggesting that OIE has the potential to be a novel adjunct candidate for breast cancer chemotherapeutic agents.

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Insights into the in vitro biological properties of Australian beach‐cast brown seaweed phenolics

Subbiah,

Ebrahimi,

Duan

et al. 2024

Food Science & Nutrition

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Five Australian seaweed species, Phyllosphora comosa, Ecklonia radiata, Durvillaea potatorum, Sargassum fallax, and Cystophora siliquosa, thrive along the country's shorelines. Some of these seaweeds have recognized health benefits but have not been fully investigated in terms of their bioactive components and mechanisms of action. We employed ultrasonication with 70% methanol to extract phenolic compounds from these seaweeds and investigated a range of bioactivities for these extracts, including anti‐inflammatory activity exploring urease inhibition, nitric oxide scavenging activity, protein denaturation inhibition, and protease inhibition. Anti‐diabetic activities were investigated using α‐amylase and α‐glucosidase inhibition assays. Anti‐proliferative and anti‐mitotic activities were evaluated using yeast‐cell and green‐gram models, respectively. Our findings showed that C. siliquosa inhibited nitric oxide, urease, and protease activities, with S. fallax, P. comosa, and E. radiata exhibiting substantial inhibition of protein denaturation. E. radiata displayed inhibitory effects on both α‐amylase and α‐glucosidase, whereas P. comosa targeted only the α‐glucosidase enzyme, indicating different mechanisms of anti‐diabetic activity. In these anti‐mitotic assays, C. siliquosa exhibited low cell viability and a significant anti‐proliferative effect, particularly within 24 h, while E. radiata demonstrated notable inhibition at 48 h. LC‐ESI‐QTOF‐MS/MS investigation identified 48 phenolic compounds, including 19 phenolic acids, 20 flavonoids, and 9 other polyphenols. The presence of these compounds in extracts correlated with observed biological activities. These results support the potential health benefits of these seaweeds and link this activity to the presence of bioactive phenolics.

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Antiproliferative effect of aqueous bark extract of Oroxylum indicum L. on Vigna radiata L. (Green gram) seedlings

Cited by 6 publications

References 0 publications

Phytochemical analysis and ethnomedicinal uses of Oroxylum indicum in Nepal

Phytochemical analysis and ethnomedicinal uses of Oroxylum indicum in Nepal

Antiproliferative, Antiangiogenic, and Antimigrastatic Effects of Oroxylum indicum (L.) Kurz Extract on Breast Cancer Cell

Insights into the in vitro biological properties of Australian beach‐cast brown seaweed phenolics

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