Antiproliferative effect of oleuropein in prostate cell lines

Vanella, Luca

doi:10.3892/ijo.2012.1428

Cited by 55 publications

(33 citation statements)

References 58 publications

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“…The research surrounding oleuropein is abundant. It has been associated with numerous health benefits including the ability to: lower blood pressure in rats [58], decrease plasma glucose concentrations in rats [55], inhibit the growth of microbes grown on agar plates [59], inhibit cultured parasitic protozoans [60] and has also shown the ability to induce apoptosis in cancer cell models: colorectal [61], breast ([61,62,63] and prostate [48]. Human trials looking into the effect of OLE on cancer do not yet exist.…”

Section: Olive Leaf Polyphenolsmentioning

confidence: 99%

“…However, olive leaf has also attracted attention as a potential cancer treatment [28,46,102,103]. In previous work, olive leaf polyphenols have demonstrated the ability to inhibit the proliferation of several cancer cell lines including pancreatic [45], leukaemia [46], breast [28,47,49], prostate [48] and colorectal [61]. Importantly, oleuropein and HT have consistently been reported to discriminate between cancer and normal cells; inhibiting proliferation and inducing apoptosis only in cancer cells [48,49].…”

Section: Olive Leaf Properties That Protect Against Development Anmentioning

confidence: 99%

“…In previous work, olive leaf polyphenols have demonstrated the ability to inhibit the proliferation of several cancer cell lines including pancreatic [45], leukaemia [46], breast [28,47,49], prostate [48] and colorectal [61]. Importantly, oleuropein and HT have consistently been reported to discriminate between cancer and normal cells; inhibiting proliferation and inducing apoptosis only in cancer cells [48,49]. The challenge with relating the anti-cancer effects in cell models to in vivo arises when considering bioavailability of the polyphenols.…”

Section: Olive Leaf Properties That Protect Against Development Anmentioning

confidence: 99%

“…In previous work, OLE polyphenols have demonstrated the ability to inhibit proliferation of several cancer cell lines including pancreatic [45], leukaemia [46] and breast [28,47]. Cellular models for breast and prostate cancers have been inhibited by the olive polyphenols oleuropein and HT [48,49,50,51]. Importantly, oleuropein and HT have consistently been reported to discriminate between cancer and normal cells; inhibiting proliferation and inducing apoptosis only in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

et al. 2016

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The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO. There are also important structural differences between polyphenols from olive leaf and those from olive fruit that may improve the capacity of OLE to enhance health outcomes. Olive polyphenols have been claimed to play an important protective role in cancer and other inflammation-related diseases. Both inflammatory and cancer cell models have shown that olive leaf polyphenols are anti-inflammatory and protect against DNA damage initiated by free radicals. The various bioactive properties of olive leaf polyphenols are a plausible explanation for the inhibition of progression and development of cancers. The pathways and signaling cascades manipulated include the NF-κB inflammatory response and the oxidative stress response, but the effects of these bioactive components may also result from their action as a phytoestrogen. Due to the similar structure of the olive polyphenols to oestrogens, these have been hypothesized to interact with oestrogen receptors, thereby reducing the prevalence and progression of hormone related cancers. Evidence for the protective effect of olive polyphenols for cancer in humans remains anecdotal and clinical trials are required to substantiate these claims idea. This review aims to amalgamate the current literature regarding bioavailability and mechanisms involved in the potential anti-cancer action of olive leaf polyphenols.

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Section: Olive Leaf Polyphenolsmentioning

confidence: 99%

Section: Olive Leaf Properties That Protect Against Development Anmentioning

confidence: 99%

Section: Olive Leaf Properties That Protect Against Development Anmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

et al. 2016

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“…Men randomized to flaxseed supplementation prior to radical prostatectomy had lower proliferation rates in their tumors compared to men randomized to control (28). Additionally, animal data suggest that components in olive oil induce apoptosis (29, 30) and inhibit migration, invasion, and adhesion of prostate cancer cells (31), and walnuts reduce prostate tumor growth (15, 32, 33) and inhibit androgen receptor expression in prostate cancer cells (34). Oxidative stress and inflammatory pathways are hypothesized to have a role in prostate cancer progression (35, 36), and based on the data from cardiovascular disease, replacing fat from animal sources with vegetable fat modulates activities of these pathways systemically.…”

Section: Discussionmentioning

confidence: 99%

Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study

Blarigan

Kenfield

Yang

et al. 2015

Cancer Causes Control

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Purpose Diet after prostate cancer diagnosis may impact disease progression. We hypothesized that consuming saturated fat after prostate cancer diagnosis would increase risk of mortality, and consuming vegetable fat after diagnosis would be lower risk of mortality. Methods This was a prospective study among 926 men with non-metastatic prostate cancer in the Physicians’ Health Study who completed a food frequency questionnaire a median of five years after diagnosis and were followed a median of 10 years after the questionnaire. We examined post-diagnostic saturated, monounsaturated, polyunsaturated, and trans fat, as well as animal and vegetable fat, intake in relation to all-cause and prostate cancer-specific mortality. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariate Cox Proportional Hazards regression. Results We observed 333 deaths (56 prostate cancer deaths) during follow-up. Men who obtained 5% more of their daily calories from saturated fat and 5% less of their daily calories from carbohydrate after diagnosis had a 1.8-fold increased risk of all cause mortality (HR: 1.81; 95% CI: 1.20, 2.74; p-value: 0.005) and a 2.8-fold increase risk of prostate cancer-specific mortality (HR: 2.78; 95% CI: 1.01, 7.64; p-value: 0.05). Men who obtained 10% more of their daily calories from vegetable fats and 10% less of their daily calories from carbohydrates had a 33% lower risk of all-cause mortality (HR: 0.67; 95% CI: 0.47, 0.96; p-value: 0.03). Conclusions Among men with non-metastatic prostate cancer, saturated fat intake may increase risk of death and vegetable fat intake may lower risk of death.

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An updated review on the potential antineoplastic actions of oleuropein

Zheng

Liu

Xiao

et al. 2021

Phytotherapy Research

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It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate keywords until the end of October 2021. Oleuropein has been shown to have antioxidant, anticancer, antiinflammatory, cardioprotective, neuroprotective, and hepatoprotective effects. Previous studies also revealed that oleuropein could effectively inhibit the malignant progression of esophageal cancer, gastric cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, prostate cancer, and cervical cancer. Recently, the role of oleuropein in inhibiting tumor cell proliferation, invasion, and migration and inducing tumor cell apoptosis has gained extensive attention. In this review, we have summarized the latest research progress related to the antioncogenic mechanisms and the potential role of oleuropein in targeting different human malignancies. Based on these findings, it can be concluded that oleuropein can function as a promising chemopreventive and chemotherapeutic agent against cancer, but its more detailed anticancer effects and underlying mechanisms need to be further validated in future preclinical as well as clinical studies.

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Antiproliferative effect of oleuropein in prostate cell lines

Cited by 55 publications

References 58 publications

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study

An updated review on the potential antineoplastic actions of oleuropein

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