Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis

Balážová, Ľudmila; Kurhajec, Slavomír; Kello, Martin; Bedlovičová, Zdenka; Zigová, Martina; Petrovová, Eva; Beňová, Katarí­na; Mojžiš, Ján; Eftimová, Jarmila

doi:10.3390/life12050767

Cited by 10 publications

(14 citation statements)

References 47 publications

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“…amurense is one of the major plants in traditional Chinese medicine. It has been used traditionally in folk medicine for hepatitis, dysentery, and gynaecological inflammation [68]. P. amurense contains mainly isoquinoline alkaloids, such as berberine chloride [69].…”

Section: Phellodendron Amurensementioning

confidence: 99%

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Lim,

Lee

2023

IJMS

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Approximately 80% of children with short stature are classified as having Idiopathic Short Stature (ISS). While growth hormone (GH) treatment received FDA approval in the United States in 2003, its long-term impact on final height remains debated. Other treatments, like aromatase inhibitors, metformin, and insulin-like growth factor-1 (IGF-1), have been explored, but there is no established standard treatment for ISS. In South Korea and other Asian countries, East Asian Traditional Medicine (EATM) is sometimes employed by parents to potentially enhance their children’s height growth, often involving herbal medicines. One such product, Astragalus membranaceus extract mixture HT042, claims to promote height growth in children and has gained approval from the Korean Food and Drug Administration (KFDA). Research suggests that HT042 supplementation can increase height growth in children without skeletal maturation, possibly by elevating serum IGF-1 and IGF-binding protein-3 levels. Preclinical studies also indicate the potential benefits of natural products, including of EATM therapies for ISS. The purpose of this review is to offer an overview of bone growth factors related to ISS and to investigate the potential of natural products, including herbal preparations, as alternative treatments for managing ISS symptoms, based on their known efficacy in in vivo studies.

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Section: Phellodendron Amurensementioning

confidence: 99%

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Lim,

Lee

2023

IJMS

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“…The deciduous tree is enriched in various chemical compounds such as limonoids, alkaloids, phenolic, polysaccharides, flavonoids, phytosterols, essential oils, and fatty acids ( Zhang et al., 2015 ). The major active ingredients are benzylisoquinoline alkaloids, including berberine, jatrorrhizine, palmatine, magnoflorine, magnocurarine, phellodendrine, and tetrahydropalmatine ( Velmurugan et al., 2017 ; Balážová et al., 2022 ; Erhan et al., 2023 ; Feng et al., 2023 ), which are commonly used as anti-inflammatory, antipyretic, and antibacterial medicines, promoting blood circulation, dysentery, diuretic, hemorrhage, and blood glucose regulating ( Kim et al., 2011 ; Steinmann et al., 2011 ; Velmurugan et al., 2017 ; Sun et al., 2019 ). The yellow, flexible, and tough wood of this medicinal plant boasts an excellent texture and can be used to create furniture and industrial art ( Sun et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated microbiome and metabolomics analysis reveal the relationship between plant-specialized metabolites and microbial community in Phellodendron amurense

Zhang,

Gao,

Tian

et al. 2024

Front. Plant Sci.

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Phellodendron amurense is the essential source of bisbenzylisoquinoline alkaloids (BIAs), making it a highly valued raw material in traditional Chinese medicine. The plant’s root secondary metabolism is intricately linked to the microbial communities that surround it. However, the root-associated microbiomes of P. amurense, as well as the potential correlation between its bioactive compounds and these microbiomes, remain poorly understood. Here, the metabolic profiles of root, rhizosphere, and bulk soils of P. amurense revealed the dramatic differences in the relative content of plant-specialized metabolites. A total of 31, 21, and 0 specialized metabolites in P. amurense were identified in the root, rhizosphere soil, and bulk soil, respectively, with higher content of the seven major BIAs observed in the rhizosphere compared with that in the bulk soils. The composition of the bulk and rhizosphere microbiomes was noticeably distinct from that of the endospheric microbiome. The phylum Cyanobacteria accounted for over 60% of the root endosphere communities, and the α-diversity in root was the lowest. Targeted seven BIAs, namely, berberine, palmatine, magnocurarine, phellodendrine, jatrorrhizine, tetrahydropalmatine, and magnoflorine, were significantly positively correlated with Nectriaceae and Sphingobacteriaceae. This study has illuminated the intricate interaction networks between P. amurense root-associated microorganisms and their key chemical compounds, providing the theoretical foundation for discovering biological fertilizers and laying the groundwork for cultivating high-quality medicinal plants.

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“…belongs to the family Rutaceae and natively grows in northern China, Korea, and Japan. It was reported that P. amurense contains rich alkaloids, including berberine, palmatine, jatrorrhizine, magnoflorine, and phellodendrine ( Mori et al., 1994 ; Xian et al., 2014 ; Wang et al., 2015 ), which exhibit various biological activities and have been widely used in clinical treatments for their antifungal ( Xiao et al., 2015 ), antibacterial ( Tsujii et al., 2020 ), anti-inflammatory ( Lee et al., 2012 ; Jung et al., 2017 ), and possible anticancer effects ( Muralimanoharan et al., 2009 ; James et al., 2011 ; Hambright et al., 2015 ; Balážová et al., 2022 ). However, the detailed microscopic distribution and roles of alkaloids in the P. amurense stem remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Microscopic distribution of alkaloids in freeze-fixed stems of Phellodendron amurense

et al. 2023

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IntroductionPhellodendron amurense Rupr. contains rich alkaloids, which have been extensively applied in clinical treatments for their various biological activities. However, detailed microscopic distribution and roles of such alkaloids in P. amurense stem still need to be clarified.MethodsIn this study, the distribution of eight alkaloids in the transverse surface of freeze-fixed P. amurense stems in fall and summer has been visualized by cryo-time-of-flight secondary ion mass spectrometry and scanning electron microscopy (cryo-TOF-SIMS/SEM), which was found in living tissues with relative contents of different alkaloids varying with the position. In addition, the contents of these alkaloids quantified by high-performance liquid chromatography (HPLC) analysis suggested the seasonal variation from fall to the following summer.Results and discussionDistribution of eight alkaloids in the freeze-fixed stems of P. amurense from fall and summer seasons has been visualized and assigned into specific living tissues, with relative contents varying in different positions with seasons, which suggested their possible roles in the physiological processes of the plant itself or plant responding to changes in the surrounding conditions.ConclusionThis study provided a significant basis for further discussion of the genes or enzymes involved in these processes, which will contribute to investigating biosynthetic pathways and specific in planta roles of alkaloids.

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Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis

Cited by 10 publications

References 47 publications

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Integrated microbiome and metabolomics analysis reveal the relationship between plant-specialized metabolites and microbial community in Phellodendron amurense

Microscopic distribution of alkaloids in freeze-fixed stems of Phellodendron amurense

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