Antiproliferative Effects of &amp;lt;i&amp;gt;Ferula assa-foetida’s&amp;lt;/i&amp;gt; Extract on PC12 and MCF7 Cancer Cells

Abroudi, Mina; Fard, Amir Ganji; Dadashizadeh, Ghazaleh; Gholami, Omid; Mahdian, Davood

doi:10.11648/j.ijbecs.20200603.12

Cited by 9 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer treatments currently available include surgery, radiation therapy, and systemic treatment such as chemotherapy, targeted therapy, hormonal therapy, and immunotherapy (Miller et al, 2019). The treatments focused on stopping the cell cycle or inducing cell death through the apoptotic or non-apoptotic application (Abroudi et al, 2020). The apoptotic or non-apoptotic applications currently available include necrosis, mitotic catastrophe, autophagy, and others (Puñal et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…Despite killing tumor cells, they also cause harm to reproduce normal cells such as in the patient's gastrointestinal tract, hair, and bone marrow, leading to side effects including nausea, vomiting, alopecia, and myelosuppression (Zaidieh et al, 2019). Despite advancements in the discovery of new pharmaceuticals, cancer treatment still requires specific and particular drugs to prevent chemotherapeutic side effects (Abroudi et al, 2020). Various natural chemicals have demonstrated promising results in the treatment and prevention of cancer, with the added benefit of fewer side effects.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Review of Malaysian Medicinal Plants with Potential Anticancer Activity

Jusoh

Aris

Jalil

et al. 2023

MAB

View full text Add to dashboard Cite

The global cancer incidence and its high mortality rate indicate limitations in its current treatment and chemotherapeutic strategies. This sparked a worldwide interest in the demand for chemical diversity in searching for therapeutic drugs derived from natural products. Natural products from medicinal plants, whether as pure compounds or crude extracts, offer inexhaustible sources of new drugs because of their unparalleled chemical diversity. This review aims to disseminate detailed information on the anticancer potential of Malaysian medicinal plants, focusing on the bioactive phytochemicals and mechanisms of action against cancer development in both in vitro and in vivo studies. A comprehensive search of PubMed, Google Scholar, Scopus, and ScienceDirect databases was conducted to find relevant articles on the anticancer activity of Malaysian medicinal plants. A total of hundred and twenty-two (122) articles on the anticancer activity of Malaysian medicinal plants was identified and reviewed. Eighty-five (85) plants (in vitro) and 16 plants (in vivo) have been identified to possess anticancer activity. The activity reported was attributed primarily to diverse chemical groups of naturally occurring phytochemicals such as flavonoids, phenolics, glycosides, quercetin, and gallic acid. Henceforth, the findings will hope to aid further research in understanding the underlaying mechanism and the efficiency of the isolation of the bioactive compounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Review of Malaysian Medicinal Plants with Potential Anticancer Activity

Jusoh

Aris

Jalil

et al. 2023

MAB

View full text Add to dashboard Cite

show abstract

“…In a similar in vitro study, Abroudi et al evaluated the anti-proliferative effect of the ethanolic extract of Ferula assa-foetida L. on pheochromocytoma (PC12) and breast cancer (MCF7). They reported that the ethanolic extract had a significant effect on apoptosis induction and cell viability [31].…”

Section: Discussionmentioning

confidence: 99%

Antitumor and Phytochemical Properties of Ferula assa-foetida L. Oleo-Gum–Resin against HT-29 Colorectal Cancer Cells In Vitro and in a Xenograft Mouse Model

Elarabany,

Hamad,

Alzamel

2023

Molecules

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the most frequently occurring tumors. Ferula assa-foetida oleo-gum–resin (OGR) extract is a traditional cooking spice known for its broad spectrum of biological activities such as antifungal, antiparasitic, and anti-inflammatory activities. This study evaluated the antitumor effect of OGR extract against HT-29 colorectal cancer cells. The OGR chemical composition was analyzed using LC–ESI–MS/MS; MTT, clonogenic assays, and a xenograft model were used to measure cytotoxicity, while apoptotic proteins were detected using Western blotting. Phytochemical analysis revealed that the extract was a rich source of isoflavones, xanthones, and other derivatives. In a dose-dependent manner, the OGR extract significantly inhibited colony formation ability and HT-29 cell growth (IC50 was 3.60 ± 0.02 and 10.5 ± 0.1 mg/mL, respectively). On the other hand, the OGR extract significantly induced apoptosis and increased the expression of some pro-death proteins involved in cellular apoptosis including PUMA, BIM, BIK, and BAK. Moreover, in a subcutaneous HT-29 xenograft model, the tumor volume and burden decreased after treatment with the OGR extract (550 ± 32 mm3 and 16.3 ± 3.6, respectively) This study demonstrated that Ferula assa-foetida OGR ethanolic extract has potential antitumor effects against HT-29 CRC cell lines by reducing cell viability and the function of apoptosis. More studies are needed to reveal the underlying mechanisms related to cytotoxicity and apoptosis induction.

show abstract

“…It also exerts regulatory effects on apoptosis and genes modulating cellular proliferation [ 34 ]. Consistently, AUR alleviates the proliferation of MCF-7 cells and suppresses cyclin D1, which is pivotal for cell cycle promotion and its dysregulation is widely observed in cancers [ 35 , 36 ]. Similar to ALA, previous studies have proposed AUR to be a metastasis inhibitor indicated by the suppression of MMP-2 and MMP-9 enzymatic activities.…”

Section: Introductionmentioning

confidence: 99%

Alpha‐Lipoic Acid, Auraptene, and Particularly Their Combination Prevent the Metastasis of U87 Human Glioblastoma Cells

Izadi

Soukhtanloo

Mirzavi

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. The primary malignant brain tumor glioblastoma multiforme (GBM) is most commonly detected in individuals over 60 years old. The standard therapeutic approach for GBM is radiotherapy combined with temozolomide. Recently, herbal products, such as alpha-lipoic acid (ALA) and auraptene (AUR), have shown promising anticancer effects on various cancer cells and animal models. However, it is not well understood how ALA, AUR, and their combination in GBM work to combat cancer. Thus, the purpose of this study was to investigate the antimetastatic effects of the ALA-AUR combination on U87 human glioblastoma cells. Methods. The inhibitory effects of ALA, AUR, and the ALA/AUR combination on the migration and metastasis of U87 cells were evaluated using a wound healing test and gelatin zymography. The expression levels of matrix metalloproteinase MMP-2 and MMP-9 were assessed at the transcriptional and translational levels using quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting, respectively. Results. Our findings revealed that combination therapy reduced cell migration and metastasis, which was indicated by the reduction in MMP-2/-9 expression both at mRNA and protein levels, as well as their enzymatic activity in U87 cells. Conclusion. This study demonstrated that the combination of ALA and AUR effectively inhibited the migration and metastasis of U87 cells. Thus, given their safety and favorable specifications, the combination of these drugs can be a promising candidate for GBM treatment as primary or adjuvant therapy.

show abstract

Antiproliferative Effects of <i>Ferula assa-foetida’s</i> Extract on PC12 and MCF7 Cancer Cells

Cited by 9 publications

References 31 publications

Review of Malaysian Medicinal Plants with Potential Anticancer Activity

Review of Malaysian Medicinal Plants with Potential Anticancer Activity

Antitumor and Phytochemical Properties of Ferula assa-foetida L. Oleo-Gum–Resin against HT-29 Colorectal Cancer Cells In Vitro and in a Xenograft Mouse Model

Alpha‐Lipoic Acid, Auraptene, and Particularly Their Combination Prevent the Metastasis of U87 Human Glioblastoma Cells

Contact Info

Product

Resources

About