Antiproliferative effects of amphiphilic molecules

Coy, Elizabeth A.; Reddy, Archana; Hostýnek, Jurij J.; Gleich, Gerald J.

doi:10.1016/0192-0561(90)90006-9

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Rats (number, gender, and strain unspecified) received a formulation containing 15% SDDBS and 13% ammonium fatty alcohol polyglycolether sulfate in drinking water. 22 A slight decrease in growth rate was observed for male rats given 2.5 mL/kg per d for 9 weeks followed by 3.75 mL/kg per d for an additional 9 weeks. Rapid weight loss was observed when the dosage was increased to 5.0 mL/kg per d at 18 weeks.…”

Section: Subchronic Oral Toxicitymentioning

confidence: 92%

“…18 Two-phase titration can be used for the determination of total cationic or anionic surfactants in mixtures. 20,21 Linear alkylbenzene sulfonate was determined by HPLC 22 ; by spectroscopic methods, particularly HPLC with UV detection; by chromatographic techniques; by spectrophotometric…”

Section: Methodsmentioning

confidence: 99%

“…At microscopic examination, hemorrhagic necrosis of the intestine and infiltration of chronic inflammatory cells were observed in dogs given 10 mg/kg and hemosiderosis of the liver and spleen was observed in dogs administered 100 and 1000 mg/kg. 22 Sodium alkylbenzene sulfonate. Freeman et al 33 reported a no observed effects level (NOEL) of 1 g/d for 6 months for dogs orally administered sodium alkylbenzene sulfonate.…”

Section: Subchronic Oral Toxicitymentioning

confidence: 99%

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Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

Becker¹,

Bergfeld²,

Belsito³

et al. 2010

Int J Toxicol

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Sodium dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactant-cleansing agents. Sodium dodecylbenzenesulfonate is soluble in water and partially soluble in alcohol, with dermal absorption dependent on pH. Dodecylbenzenesulfonate salts are not toxic in single-dose oral and dermal animal tests, and no systemic toxicities were observed in repeat-dose dermal animal studies. In dermal animal studies, no evidence of reproductive or developmental toxicity was reported. At 15% concentrations, sodium dodecylbenzenesulfonate was severely irritating to rabbit skin. The Cosmetic Ingredient Review Expert Panel concluded that the irritant properties of these ingredients are similar to those of other detergents, with severity dependent on concentration and pH. Products containing these ingredients should be formulated to ensure that the irritancy potential is minimized.

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Section: Subchronic Oral Toxicitymentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Subchronic Oral Toxicitymentioning

confidence: 99%

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Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

Becker¹,

Bergfeld²,

Belsito³

et al. 2010

Int J Toxicol

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“…For example, steroids such as fluorohydrocortisone and methylprednisolone, suppress phytohemagglutinin (PHA) stimulated T cell blastogenesis (Langhoff et al, 1985). The immunosuppressive, long chain amphiphilic mol-ecules were found to be antiproliferative (Coy et al, 1990). Cannabinoids and cocaine have been found to suppress mitogen-induced T cell proliferation both in human and murine systems (Luo et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Suppressive Effect of Honey on Antigen/Mitogen Stimulated Murine T Cell Proliferation

Duddukuri

Rao

Athota

2002

Pharmaceutical Biology

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It has been reported that the intraperitoneal administration of honey suppressed the induction of antigen-specific humoral antibody response in mice as determined by passive cutaneous anaphylaxis and Ouchterlony double immunodiffusion tests. Hence, we studied the effect of honey on induction of antigen-specific IgG antibody response and found suppression in mice as determined by ELISA and also T cell proliferation in vitro. T cell proliferation induced by antigens such as ovalbumin, diphtheria toxoid and tetanus toxoid, as well as the mitogens concanavalin A and phytohemagglutinin, was significantly suppressed by various doses of natural and commercial honeys, as evaluated by 3 H-thymidine incorporation. Furthermore, the suppressive effect of honey was also confirmed on antigen-or mitogen-induced T cell proliferative responses using splenic T cells from different haplotypes of mice. The results obtained in this work confirm the antiproliferative activity of honey.

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Final Report on the Safety Assessment of Sodium Dodecylbenzenesulfonate/TEA-Dodecylbenzenesulfonate/ Sodium Decylbenzenesulfonate

1993

Journal of the American College of Toxicology

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The oral LD50 for Sodium Dodecylbenzenesulfonate (SDDBS) in rats was 1.26 g/kg. No significant toxic effects were observed when rats were given oral doses of 1000 ppm SDDBS in water. No systemic toxicity was observed in rabbits given dermal applications of ≤10% SDDBS to abraded skin for 28 days; severe dermal irritation was observed at the application site. Mild necrosis of intestinal mucosa with hemosiderosis of the spleen, liver, and kidneys was observed in rats given a varying dosage of 2.5–5.0 ml/kg/day of a formulation containing 15% SDDBS for a total of 22 weeks; lesions were not observed for rats given 0.5 ml/kg/day. Renal damage was observed in rats dosed orally with ≤0.6% SDDBS for 6 months. For dogs fed ≤1000 mg/kg/day of a formulation containing 15% SDDBS in the diet for 6 months, hemorrhagic necrosis of the intestine and infiltration of inflammatory cells were observed at 10 mg/kg and hemosiderosis of the liver and spleen was observed at 100 and 1000 mg/kg. SDDBS, adjusted to 15% active and a p H of 7.0, applied to intact and abraded sites was severely irritating. A solution containing 1.9% SDDBS and 1.9% tallow alkyl ethoxylate sulfate was moderately irritating to the skin of rabbits. This compound was not a sensitizer when tested at low concentrations. Concentrations of ≥5% Linear Alkylbenzene Sulfonate (LAS) were irritants to the eyes of rabbits; ≤0.1 % LAS produced mild to no irritation. (LAS is a commercial preparation that has the average molecular weight of SDDBS.) No reproductive effects were produced by dermal application of LAS or TEA-DDBS or by oral administration of LAS. The results of mutagenic assays using SDDBS were negative. Dermal carcinogenicity studies using LAS and TEA-DDBS and oral carcinogenicity studies using SDDBS and LAS were negative. On the basis of the animal and clinical data presented in this report, it is concluded that Sodium Dodecylbenzenesulfonate, TEA-Dodecylbenzenesulfonate, and Sodium Decylbenzenesulfonate are safe as cosmetic ingredients in the present practices of use. The full report includes a discussion on how the various types of safety test data were interpreted, both individually and collectively.

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Antiproliferative effects of amphiphilic molecules

Cited by 3 publications

References 10 publications

Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

Suppressive Effect of Honey on Antigen/Mitogen Stimulated Murine T Cell Proliferation

Final Report on the Safety Assessment of Sodium Dodecylbenzenesulfonate/TEA-Dodecylbenzenesulfonate/ Sodium Decylbenzenesulfonate

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