Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Yen, Ching Yu; Chiu, Chien‐Chih; Haung, Rou Wen; Yeh, Ching-Sheng; Huang, Kuang Jing; Chang, Kao-Ping; Hseu, You Cheng; Chang, Fang Rong; Chang, Hsueh-Wei; Wu, Yang Chang

doi:10.1016/j.mrgentox.2012.06.003

Cited by 64 publications

(56 citation statements)

References 48 publications

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“…Results showed that treatment with extract alters the level of Bax and Bcl-2 genes and induced high level of ROS in cells which points that reactive oxygen species may be responsible for induction of apoptosis. Growth inhibitory potential of goniothalamin on the Ca9-22 oral cancer cell line were tested by Yen et al (2012). Results obtained from this study demonstrated that goniothalamin inhibited growth via ROS induction, DNA damage and mitochondria dysfunction and further studies are required to tap the potential of goniothalamin for the development of a drug against oral cancer.…”

Section: Phytoconstituents As Ros Inducersmentioning

confidence: 94%

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

et al. 2015

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Advancement in the field of cancer molecular biology has aided researchers to develop various new chemopreventive agents which can target cancer cells exclusively. Cancer chemopreventive agents have proficiency to inhibit, reverse and delay process of carcinogenesis during its early and later course. Chemopreventive agents can act as antioxidative, antimutagenic/antigenotoxic, anti-inflammatory agents or via aiming various molecular targets in a cell to induce cell death. Apoptosis is a kind of cell death which shows various cellular morphological alterations such as cell shrinkage, blebbing of membrane, chromatin condensation, DNA fragmentation, formation of apoptotic bodies etc. Nowadays, apoptosis is being one of the new approaches for the identification and development of novel anticancer therapies. For centuries, plants are known to play part in daily routine from providing food to management of human health. In the last two decades, diverse phytochemicals and various botanical formulations have been characterized as agents that possess potential to execute cancer cells via inducing apoptosis. Data obtained from the research carried out globally pointed out that natural products are the potential candidates which have capability to combat cancer. In the present review, we surveyed literature on natural products which throws light on the mechanism through which these phytochemicals induce apoptosis in cancer cells.

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Section: Phytoconstituents As Ros Inducersmentioning

confidence: 94%

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

et al. 2015

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“…GTN had been able to induce cytotoxicity in a variety of cancer cell lines including vascular smooth muscle cells (VSMCs), Chinese hamster ovary cells, renal cells [69–71], hepatoblastoma [72, 73], gastric, kidney cells, breast carcinomas, leukemia, Jurkat cells [67, 69, 74–84], hepatocellular carcinoma [85], lung cancer cells [86], oral cancer cells [87, 88], and HeLa cells [89, 90] but sparing the normal cells including blood cells [83]. …”

Section: Mechanism Of Actionmentioning

confidence: 99%

Emerging Anticancer Potentials of Goniothalamin and Its Molecular Mechanisms

Ali-Seyed

Jantan

Bukhari

2014

BioMed Research International

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The treatment of most cancers is still inadequate, despite tremendous steady progress in drug discovery and effective prevention. Nature is an attractive source of new therapeutics. Several medicinal plants and their biomarkers have been widely used for the treatment of cancer with less known scientific basis of their functioning. Although a wide array of plant derived active metabolites play a role in the prevention and treatment of cancer, more extensive scientific evaluation of their mechanisms is still required. Styryl-lactones are a group of secondary metabolites ubiquitous in the genus Goniothalamus that have demonstrated to possess antiproliferative activity against cancer cells. A large body of evidence suggests that this activity is associated with the induction of apoptosis in target cells. In an effort to promote further research on the genus Goniothalamus, this review offers a broad analysis of the current knowledge on Goniothalamin (GTN) or 5, 6, dihydro-6-styryl-2-pyronone (C13H12O2), a natural occurring styryl-lactone. Therefore, it includes (i) the source of GTN and other metabolites; (ii) isolation, purification, and (iii) the molecular mechanisms of actions of GTN, especially the anticancer properties, and summarizes the role of GTN which is crucial for drug design, development, and application in future for well-being of humans.

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“…It is cytotoxic to and induces apoptosis in cancer cells such as cervical cancer (HeLa), breast carcinoma MCF-7 cell lines and colon cancer HT29 cells (Alabsi et al, 2012); Ca9-22 oral cancer cells (Yen et al, 2012); hepatoblastoma HepG2 cells (Al-Qubaisi et al, 2011); human lung cancer cells (Chiu et al, 2011); Jurkat T leukemia cells (Inayat-Hussain et al, 2010); and invasive breast carcinoma MDA-MB231 cell lines (Chen et al, 2005). It is also toxic to normal mouse fibroblast 3T3 cells (Alabsi et al, 2012), coronary artery smooth muscle cells , vascular smooth muscle cells (Chan et al, 2006).…”

Section: Introductionmentioning

confidence: 99%