Antiproliferative effects of isopentenylated coumarins isolated from <b> <i>Phellolophium madagascariense</i> </b> Baker

Rivière, Claude; Goossens, Laurence; Pommery, Nicole; Fourneau, Christophe; Delelis, A; Henichart, J. P.

doi:10.1080/14786410500277787

Cited by 39 publications

(34 citation statements)

References 16 publications

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“…Its previously reported activity referred to anticancer. 13 MH, located in the peel of Citrus maxima fruit 14 and Murraya paniculata, 15 was recently isolated from FA by us for the first time.…”

Section: Introductionmentioning

confidence: 99%

Meranzin Hydrate Induces Similar Effect to Fructus Aurantii on Intestinal Motility through Activation of H1 Histamine Receptors

Huang

Xing

et al. 2011

Journal of Gastrointestinal Surgery

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This experiment studied the potential effect of meranzin hydrate (MH) and decoction of herb Fructus Aurantii (FA) on rat gut motility. It also investigated the prokinetic mechanism of MH. Experiments were performed on male Sprague–Dawley rats (200–220 g). The study included: (1) qualitation of MH and four other known compounds in FA and jejunum after oral administration of FA decoction to rats; (2) in vitro experiment of MH on rat jejunum contractions; (3) in vivo experiment of FA and MH in rats. Dose-dependently, MH (1–100 μM) increased amplitude in longitudinal and circular jejunum muscles. Pretreatment of jejunum longitudinal strips with benzhydramine (1 μM) remarkably inhibited the contractions induced by histamine (1 μM) and MH (10 or 30 μM). Pretreatment of jejunum longitudinal strips with atropine (1 μM) reduced the contractions induced by acetylcholine (1 μM) but did not influence the contractions induced by MH (10 or 30 μM). Interestingly, the antagonism of benzhydramine to MH was also verified in vivo. MH can be absorbed into the jejunum following oral administration of FA decoction. In healthy rats, MH (7, 14, and 28 mg/kg) and FA (3.3, 10, and 20 g/kg) both promoted intestinal transit and gastric emptying in a dose-dependent manner when gavaged acutely. In cisplatin model rats, MH (14 and 28 mg/kg) significantly reversed cisplatin-induced delay in gastric emptying. Meranzin hydrate can induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors.

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Section: Introductionmentioning

confidence: 99%

Meranzin Hydrate Induces Similar Effect to Fructus Aurantii on Intestinal Motility through Activation of H1 Histamine Receptors

Huang

Xing

et al. 2011

Journal of Gastrointestinal Surgery

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“…Furthermore, the positive optical rotation value of 1 ([α] 25 +3.8 o ) was in good agreement with that of related (2'R)-hydroxy-coumarin derivatives. 15,16 The known compounds, osthenol (2), 17 (2'R)-7-hydroxy-8-(2',3'-dihydroxy-3'-methylbutyl)-2H-1-benzopyran-2-one (3), 18 columbianetin (4), 19 and seselin (5) 20 were also isolated. Their structures were identified by comparing their spectroscopic data with those in the literature.…”

Section: Previous Chemical Investigations On Limonia Acidissima Lmentioning

confidence: 99%

Limodissimin A: A New Dimeric Coumarin from Limonia acidissima

Kim¹,

Ha²,

Kim³

et al. 2009

Bulletin of the Korean Chemical Society

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“…Previous investigations have shown that osthole possesses various beneficial pharmacological activities including: anti-osteoporotic, anti-inflammatory, anti-allergic, anti-seizure, and anti-diabetic effects [12,13,14,15]. Moreover, accumulating evidence has shown that osthole exerts anti-cancer effects through inducing cell cycle arrest and apoptotic cell death [16,17,18]. Recent studies have also shown that osthole is able to inhibit the migration and invasion of cancer cells through suppression of MMP-2 and MMP-9 enzyme activities [19,20].…”

Section: Introductionmentioning

confidence: 99%

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway

Chen

Zhou

Ning

et al. 2015

Cell Physiol Biochem

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Background: Drug combination therapies using cisplatin and natural products are common practice in the treatment of human lung cancer. Osthole is a natural compound extracted from a number of medicinal plants and has been shown to exert strong anticancer activities with low toxicity. Methods: In the present study, NBM-T-BMX-OS01 (BMX), derived from the semi-synthesis of osthole, was evaluated in cisplatin treated A549 cells to investigate its effect on cisplatin resistance in human lung cancer. The anticancer effect of BMX were measured by cell viablity‚ colony formation‚ TUNEL staining‚ flow cytometry and cell cycle assay. The fluorescence staining was performed to detect intracellular and mitochondrial reactive oxygen species (ROS) generation. Western blot analysis, antagonists pretreatment and small interfering RNA (siRNA) transfection were used to determine the potential mechanism. Results: It was found that, in comparison with single cisplatin treatment, the combination of BMX and cisplatin resulted in greater efficacy in inhibition of proliferation and colony formation, apoptosis induction and cell cycle arrest. The results of fluorescence staining showed that the combination effect of BMX and cisplatin was due to oxidative stress induced by mitochondrial ROS generation. In addition, BMX significantly attenuated the phosphorylation of ERK and Akt, two important pro-survival kinases. In contrast, BMX inhibited the activation of AMPK, and knockdown of AMPK using specific siRNA partially reversed BMX-induced inhibition of ERK and Akt, as well as its synthetic effects on cisplatin induced anticancer activity in A549 cells. Conclusion: Taken together, this study provides that BMX might modulate cisplatin resistance through AMPK-ERK and AMPK-Akt pathways. These results also support the role of BMX as a potential drug candidate for use in combination with cisplatin in the treatment of human lung cancer.

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Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker

Cited by 39 publications

References 16 publications

Meranzin Hydrate Induces Similar Effect to Fructus Aurantii on Intestinal Motility through Activation of H1 Histamine Receptors

Meranzin Hydrate Induces Similar Effect to Fructus Aurantii on Intestinal Motility through Activation of H1 Histamine Receptors

Limodissimin A: A New Dimeric Coumarin from Limonia acidissima

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway

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